Low magnitude and high frequency vibration prevents simulated microgravity-induced decrease in a bone formation response in osteoblasts

Mamta Patel; Roger Talish; Clinton Rubin; Hanjoong Jo

doi:10.2514/6.iac-06-a1.4.09

Low magnitude and high frequency vibration prevents simulated microgravity-induced decrease in a bone formation response in osteoblasts

Mamta Patel
, Roger Talish
, Clinton Rubin
, Hanjoong Jo

Georgia Institute of Technology
Juvent, Inc.
Emory University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Bone loss is a serious concern for human-based space exploration, and to date, it has not been adequately counteracted. Here, we provide preliminary data showing that low magnitude and high frequency mechanical vibration prevents decreased bone formation caused by simulated microgravity using the Random Positioning Machine. Experiments were performed for 3 days, and 2T3 preosteoblast cells were exposed to a vibration of 0.3g magnitude and at 30Hz frequency for 10 minutes/day before measuring ALP activity, a marker of cell differentiation. Thus, brief daily exposure of low magnitude and high frequency mechanical signals may countermeasure bone loss in spaceflight.

Original language	English
Title of host publication	AIAA 57th International Astronautical Congress, IAC 2006
Publisher	American Institute of Aeronautics and Astronautics Inc.
Pages	225-226
Number of pages	2
ISBN (Print)	9781605600390
DOIs	https://doi.org/10.2514/6.iac-06-a1.4.09
State	Published - 2006
Event	AIAA 57th International Astronautical Congress, IAC 2006 - Valencia, Spain Duration: Oct 2 2006 → Oct 6 2006

Publication series

Name	AIAA 57th International Astronautical Congress, IAC 2006
Volume	1

Conference

Conference	AIAA 57th International Astronautical Congress, IAC 2006
Country/Territory	Spain
City	Valencia
Period	10/2/06 → 10/6/06

Access to Document

10.2514/6.iac-06-a1.4.09

Cite this

Patel, M., Talish, R., Rubin, C., & Jo, H. (2006). Low magnitude and high frequency vibration prevents simulated microgravity-induced decrease in a bone formation response in osteoblasts. In AIAA 57th International Astronautical Congress, IAC 2006 (pp. 225-226). (AIAA 57th International Astronautical Congress, IAC 2006; Vol. 1). American Institute of Aeronautics and Astronautics Inc.. https://doi.org/10.2514/6.iac-06-a1.4.09

Patel, Mamta ; Talish, Roger ; Rubin, Clinton et al. / Low magnitude and high frequency vibration prevents simulated microgravity-induced decrease in a bone formation response in osteoblasts. AIAA 57th International Astronautical Congress, IAC 2006. American Institute of Aeronautics and Astronautics Inc., 2006. pp. 225-226 (AIAA 57th International Astronautical Congress, IAC 2006).

@inproceedings{d6b1b43f5667435c9b890b3b468a930e,

title = "Low magnitude and high frequency vibration prevents simulated microgravity-induced decrease in a bone formation response in osteoblasts",

abstract = "Bone loss is a serious concern for human-based space exploration, and to date, it has not been adequately counteracted. Here, we provide preliminary data showing that low magnitude and high frequency mechanical vibration prevents decreased bone formation caused by simulated microgravity using the Random Positioning Machine. Experiments were performed for 3 days, and 2T3 preosteoblast cells were exposed to a vibration of 0.3g magnitude and at 30Hz frequency for 10 minutes/day before measuring ALP activity, a marker of cell differentiation. Thus, brief daily exposure of low magnitude and high frequency mechanical signals may countermeasure bone loss in spaceflight.",

author = "Mamta Patel and Roger Talish and Clinton Rubin and Hanjoong Jo",

year = "2006",

doi = "10.2514/6.iac-06-a1.4.09",

language = "English",

isbn = "9781605600390",

series = "AIAA 57th International Astronautical Congress, IAC 2006",

publisher = "American Institute of Aeronautics and Astronautics Inc.",

pages = "225--226",

booktitle = "AIAA 57th International Astronautical Congress, IAC 2006",

note = "AIAA 57th International Astronautical Congress, IAC 2006 ; Conference date: 02-10-2006 Through 06-10-2006",

}

Patel, M, Talish, R, Rubin, C & Jo, H 2006, Low magnitude and high frequency vibration prevents simulated microgravity-induced decrease in a bone formation response in osteoblasts. in AIAA 57th International Astronautical Congress, IAC 2006. AIAA 57th International Astronautical Congress, IAC 2006, vol. 1, American Institute of Aeronautics and Astronautics Inc., pp. 225-226, AIAA 57th International Astronautical Congress, IAC 2006, Valencia, Spain, 10/2/06. https://doi.org/10.2514/6.iac-06-a1.4.09

Low magnitude and high frequency vibration prevents simulated microgravity-induced decrease in a bone formation response in osteoblasts. / Patel, Mamta; Talish, Roger; Rubin, Clinton et al.
AIAA 57th International Astronautical Congress, IAC 2006. American Institute of Aeronautics and Astronautics Inc., 2006. p. 225-226 (AIAA 57th International Astronautical Congress, IAC 2006; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Low magnitude and high frequency vibration prevents simulated microgravity-induced decrease in a bone formation response in osteoblasts

AU - Patel, Mamta

AU - Talish, Roger

AU - Rubin, Clinton

AU - Jo, Hanjoong

PY - 2006

Y1 - 2006

N2 - Bone loss is a serious concern for human-based space exploration, and to date, it has not been adequately counteracted. Here, we provide preliminary data showing that low magnitude and high frequency mechanical vibration prevents decreased bone formation caused by simulated microgravity using the Random Positioning Machine. Experiments were performed for 3 days, and 2T3 preosteoblast cells were exposed to a vibration of 0.3g magnitude and at 30Hz frequency for 10 minutes/day before measuring ALP activity, a marker of cell differentiation. Thus, brief daily exposure of low magnitude and high frequency mechanical signals may countermeasure bone loss in spaceflight.

AB - Bone loss is a serious concern for human-based space exploration, and to date, it has not been adequately counteracted. Here, we provide preliminary data showing that low magnitude and high frequency mechanical vibration prevents decreased bone formation caused by simulated microgravity using the Random Positioning Machine. Experiments were performed for 3 days, and 2T3 preosteoblast cells were exposed to a vibration of 0.3g magnitude and at 30Hz frequency for 10 minutes/day before measuring ALP activity, a marker of cell differentiation. Thus, brief daily exposure of low magnitude and high frequency mechanical signals may countermeasure bone loss in spaceflight.

UR - https://www.scopus.com/pages/publications/41149135403

U2 - 10.2514/6.iac-06-a1.4.09

DO - 10.2514/6.iac-06-a1.4.09

M3 - Conference contribution

AN - SCOPUS:41149135403

SN - 9781605600390

T3 - AIAA 57th International Astronautical Congress, IAC 2006

SP - 225

EP - 226

BT - AIAA 57th International Astronautical Congress, IAC 2006

PB - American Institute of Aeronautics and Astronautics Inc.

T2 - AIAA 57th International Astronautical Congress, IAC 2006

Y2 - 2 October 2006 through 6 October 2006

ER -

Patel M, Talish R, Rubin C, Jo H. Low magnitude and high frequency vibration prevents simulated microgravity-induced decrease in a bone formation response in osteoblasts. In AIAA 57th International Astronautical Congress, IAC 2006. American Institute of Aeronautics and Astronautics Inc. 2006. p. 225-226. (AIAA 57th International Astronautical Congress, IAC 2006). doi: 10.2514/6.iac-06-a1.4.09

Low magnitude and high frequency vibration prevents simulated microgravity-induced decrease in a bone formation response in osteoblasts

Abstract

Publication series

Conference

Access to Document

Other files and links

Fingerprint

Cite this