Low temperature co-fired ceramic package for lab-on-CMOS applied in cell viability monitoring

Niina Halonen; Joni Kilpijärvi; Maciej Sobocinski; Timir Datta-Chaudhuri; Antti Hassinen; Someshekar B. Prakash; Peter Möller; Pamela Abshire; Elisabeth Smela; Sakari Kellokumpu; Anita Lloyd Spetz

doi:10.1016/j.proeng.2015.08.769

Low temperature co-fired ceramic package for lab-on-CMOS applied in cell viability monitoring

Niina Halonen
, Joni Kilpijärvi
, Maciej Sobocinski
, Timir Datta-Chaudhuri
, Antti Hassinen
, Someshekar B. Prakash
, Peter Möller
, Pamela Abshire
, Elisabeth Smela
, Sakari Kellokumpu
, Anita Lloyd Spetz

Electrical Engineering

University of Oulu
University of Maryland, College Park
Intel
Linköping University

Research output: Contribution to journal › Conference article › peer-review

6 Scopus citations

Abstract

Lab-on-CMOS chips (LOCMOS) are sophisticated miniaturized analysis tools based on integrated circuit (IC) microchips performing various laboratory functions. We have developed a low temperature co-fired ceramic (LTCC) package for a LOCMOS application regarding cytotoxicity assessment of nanomaterials. The LTCC packaged capacitance sensor chip is designed for long-term cell viability monitoring during nanoparticle exposure. The introduced LTCC package utilizes the flip chip bonding technique, and it is biocompatible as well as able to withstand the environmental conditions required to maintain mammalian cell culture directly on the surface of a complementary metal oxide semiconductor (CMOS) integrated circuit.

Original language	English
Pages (from-to)	1079-1082
Number of pages	4
Journal	Procedia Engineering
Volume	120
DOIs	https://doi.org/10.1016/j.proeng.2015.08.769
State	Published - 2015
Event	29th European Conference on Solid-State Transducers, EUROSENSORS 2015; Freiburg; Germany; 6 September 2015 through 9 September 2015. - Freiburg, Germany Duration: Sep 6 2015 → Sep 9 2015

Keywords

Capacitance sensing
Cytotoxicity assesment
Electronics packaging
Lab-on-CMOS
Low temperature co-fired ceramics

Access to Document

10.1016/j.proeng.2015.08.769

Cite this

@article{f9a47ab3d9384d15a332cac15de937d8,

title = "Low temperature co-fired ceramic package for lab-on-CMOS applied in cell viability monitoring",

abstract = "Lab-on-CMOS chips (LOCMOS) are sophisticated miniaturized analysis tools based on integrated circuit (IC) microchips performing various laboratory functions. We have developed a low temperature co-fired ceramic (LTCC) package for a LOCMOS application regarding cytotoxicity assessment of nanomaterials. The LTCC packaged capacitance sensor chip is designed for long-term cell viability monitoring during nanoparticle exposure. The introduced LTCC package utilizes the flip chip bonding technique, and it is biocompatible as well as able to withstand the environmental conditions required to maintain mammalian cell culture directly on the surface of a complementary metal oxide semiconductor (CMOS) integrated circuit.",

keywords = "Capacitance sensing, Cytotoxicity assesment, Electronics packaging, Lab-on-CMOS, Low temperature co-fired ceramics",

author = "Niina Halonen and Joni Kilpij{\"a}rvi and Maciej Sobocinski and Timir Datta-Chaudhuri and Antti Hassinen and Prakash, \{Someshekar B.\} and Peter M{\"o}ller and Pamela Abshire and Elisabeth Smela and Sakari Kellokumpu and Spetz, \{Anita Lloyd\}",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors. Published by Elsevier Ltd.; 29th European Conference on Solid-State Transducers, EUROSENSORS 2015; Freiburg; Germany; 6 September 2015 through 9 September 2015. ; Conference date: 06-09-2015 Through 09-09-2015",

year = "2015",

doi = "10.1016/j.proeng.2015.08.769",

language = "English",

volume = "120",

pages = "1079--1082",

journal = "Procedia Engineering",

issn = "1877-7058",

}

TY - JOUR

T1 - Low temperature co-fired ceramic package for lab-on-CMOS applied in cell viability monitoring

AU - Halonen, Niina

AU - Kilpijärvi, Joni

AU - Sobocinski, Maciej

AU - Datta-Chaudhuri, Timir

AU - Hassinen, Antti

AU - Prakash, Someshekar B.

AU - Möller, Peter

AU - Abshire, Pamela

AU - Smela, Elisabeth

AU - Kellokumpu, Sakari

AU - Spetz, Anita Lloyd

PY - 2015

Y1 - 2015

N2 - Lab-on-CMOS chips (LOCMOS) are sophisticated miniaturized analysis tools based on integrated circuit (IC) microchips performing various laboratory functions. We have developed a low temperature co-fired ceramic (LTCC) package for a LOCMOS application regarding cytotoxicity assessment of nanomaterials. The LTCC packaged capacitance sensor chip is designed for long-term cell viability monitoring during nanoparticle exposure. The introduced LTCC package utilizes the flip chip bonding technique, and it is biocompatible as well as able to withstand the environmental conditions required to maintain mammalian cell culture directly on the surface of a complementary metal oxide semiconductor (CMOS) integrated circuit.

AB - Lab-on-CMOS chips (LOCMOS) are sophisticated miniaturized analysis tools based on integrated circuit (IC) microchips performing various laboratory functions. We have developed a low temperature co-fired ceramic (LTCC) package for a LOCMOS application regarding cytotoxicity assessment of nanomaterials. The LTCC packaged capacitance sensor chip is designed for long-term cell viability monitoring during nanoparticle exposure. The introduced LTCC package utilizes the flip chip bonding technique, and it is biocompatible as well as able to withstand the environmental conditions required to maintain mammalian cell culture directly on the surface of a complementary metal oxide semiconductor (CMOS) integrated circuit.

KW - Capacitance sensing

KW - Cytotoxicity assesment

KW - Electronics packaging

KW - Lab-on-CMOS

KW - Low temperature co-fired ceramics

UR - https://www.scopus.com/pages/publications/84985017647

U2 - 10.1016/j.proeng.2015.08.769

DO - 10.1016/j.proeng.2015.08.769

M3 - Conference article

AN - SCOPUS:84985017647

SN - 1877-7058

VL - 120

SP - 1079

EP - 1082

JO - Procedia Engineering

JF - Procedia Engineering

T2 - 29th European Conference on Solid-State Transducers, EUROSENSORS 2015; Freiburg; Germany; 6 September 2015 through 9 September 2015.

Y2 - 6 September 2015 through 9 September 2015

ER -

Low temperature co-fired ceramic package for lab-on-CMOS applied in cell viability monitoring

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this