Lung cancer among firefighters: Smoking-adjusted risk estimates in a pooled analysis of case-control studies

Carolina Bigert; Per Gustavsson; Kurt Straif; Dirk Taeger; Beate Pesch; Benjamin Kendzia; Joachim Schüz; Isabelle Stücker; Florence Guida; Irene Brüske; Heinz Erich Wichmann; Angela C. Pesatori; Maria Teresa Landi; Neil Caporaso; Lap Ah Tse; Ignatius Tak Sun Yu; Jack Siemiatycki; Jérôme Lavoué; Lorenzo Richiardi; Dario Mirabelli; Lorenzo Simonato; Karl Heinz Jöckel; Wolfgang Ahrens; Hermann Pohlabeln; Adonina Tardón; David Zaridze; John K. Field; Andrea'T Mannetje; Neil Pearce; John McLaughlin; Paul Demers; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Rodica Stanescu Dumitru; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Paolo Boffetta; Susan Peters; Roel Vermeulen; Hans Kromhout; Thomas Brüning; Ann C. Olsson

doi:10.1097/JOM.0000000000000878

Lung cancer among firefighters: Smoking-adjusted risk estimates in a pooled analysis of case-control studies

Carolina Bigert
, Per Gustavsson
, Kurt Straif
, Dirk Taeger
, Beate Pesch
, Benjamin Kendzia
, Joachim Schüz
, Isabelle Stücker
, Florence Guida
, Irene Brüske
, Heinz Erich Wichmann
, Angela C. Pesatori
, Maria Teresa Landi
, Neil Caporaso
, Lap Ah Tse
, Ignatius Tak Sun Yu
, Jack Siemiatycki
, Jérôme Lavoué
, Lorenzo Richiardi
, Dario Mirabelli

Lorenzo Simonato, Karl Heinz Jöckel, Wolfgang Ahrens, Hermann Pohlabeln, Adonina Tardón, David Zaridze, John K. Field, Andrea'T Mannetje, Neil Pearce, John McLaughlin, Paul Demers, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Rodica Stanescu Dumitru, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Paolo Boffetta, Susan Peters, Roel Vermeulen, Hans Kromhout, Thomas Brüning, Ann C. Olsson

Family , Population and Preventative Medicine

Karolinska Institutet
International Agency for Research on Cancer
Ruhr University Bochum
Institut national de la santé et de la recherche médicale
Université Paris-Saclay
Deutsches Forschungszentrum für Gesundheit und Umwelt
Ludwig Maximilian University of Munich
Technical University of Munich
University of Milan
National Institutes of Health
Chinese University of Hong Kong
Centre Hospitalier de L'Universite de Montreal
University of Turin
University of Padua
University of Duisburg-Essen
Leibniz Institute for Prevention Research and Epidemiology
University of Oviedo
Blokhin Cancer Research Center
University of Liverpool
Massey University
Public Health Ontario
Cancer Care Ontario
Nofer Institute of Occupational Medicine
Maria Sklodowska-Curie Institute of Oncology
National Public Health Center
Regional Authority of Public Health
National Institute of Public Health
Charles University
Masaryk Memorial Cancer Institute
Palacký University Olomouc
University of Ostrava
Utrecht University
University of Western Australia

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Objectives: The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking. Methods: We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk of lung cancer. Results: There was no increased lung cancer risk overall or by specific cell type among firefighters (n=190), neither before nor after smoking adjustment. We observed no significant exposure-response relationship in terms of work duration. Conclusions: We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter.

Original language	English
Pages (from-to)	1137-1143
Number of pages	7
Journal	Journal of Occupational and Environmental Medicine
Volume	58
Issue number	11
DOIs	https://doi.org/10.1097/JOM.0000000000000878
State	Published - Nov 28 2016

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Bigert, C., Gustavsson, P., Straif, K., Taeger, D., Pesch, B., Kendzia, B., Schüz, J., Stücker, I., Guida, F., Brüske, I., Wichmann, H. E., Pesatori, A. C., Landi, M. T., Caporaso, N., Tse, L. A., Yu, I. T. S., Siemiatycki, J., Lavoué, J., Richiardi, L., ... Olsson, A. C. (2016). Lung cancer among firefighters: Smoking-adjusted risk estimates in a pooled analysis of case-control studies. Journal of Occupational and Environmental Medicine, 58(11), 1137-1143. https://doi.org/10.1097/JOM.0000000000000878

@article{fa7996d6c2cd4b39ade603bb96bdf1fc,

title = "Lung cancer among firefighters: Smoking-adjusted risk estimates in a pooled analysis of case-control studies",

abstract = "Objectives: The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking. Methods: We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk of lung cancer. Results: There was no increased lung cancer risk overall or by specific cell type among firefighters (n=190), neither before nor after smoking adjustment. We observed no significant exposure-response relationship in terms of work duration. Conclusions: We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter.",

author = "Carolina Bigert and Per Gustavsson and Kurt Straif and Dirk Taeger and Beate Pesch and Benjamin Kendzia and Joachim Sch{\"u}z and Isabelle St{\"u}cker and Florence Guida and Irene Br{\"u}ske and Wichmann, \{Heinz Erich\} and Pesatori, \{Angela C.\} and Landi, \{Maria Teresa\} and Neil Caporaso and Tse, \{Lap Ah\} and Yu, \{Ignatius Tak Sun\} and Jack Siemiatycki and J{\'e}r{\^o}me Lavou{\'e} and Lorenzo Richiardi and Dario Mirabelli and Lorenzo Simonato and J{\"o}ckel, \{Karl Heinz\} and Wolfgang Ahrens and Hermann Pohlabeln and Adonina Tard{\'o}n and David Zaridze and Field, \{John K.\} and Andrea'T Mannetje and Neil Pearce and John McLaughlin and Paul Demers and Neonila Szeszenia-Dabrowska and Jolanta Lissowska and Peter Rudnai and Eleonora Fabianova and Dumitru, \{Rodica Stanescu\} and Vladimir Bencko and Lenka Foretova and Vladimir Janout and Paolo Boffetta and Susan Peters and Roel Vermeulen and Hans Kromhout and Thomas Br{\"u}ning and Olsson, \{Ann C.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2016 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited.",

year = "2016",

month = nov,

day = "28",

doi = "10.1097/JOM.0000000000000878",

language = "English",

volume = "58",

pages = "1137--1143",

journal = "Journal of Occupational and Environmental Medicine",

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Bigert, C, Gustavsson, P, Straif, K, Taeger, D, Pesch, B, Kendzia, B, Schüz, J, Stücker, I, Guida, F, Brüske, I, Wichmann, HE, Pesatori, AC, Landi, MT, Caporaso, N, Tse, LA, Yu, ITS, Siemiatycki, J, Lavoué, J, Richiardi, L, Mirabelli, D, Simonato, L, Jöckel, KH, Ahrens, W, Pohlabeln, H, Tardón, A, Zaridze, D, Field, JK, Mannetje, AT, Pearce, N, McLaughlin, J, Demers, P, Szeszenia-Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Dumitru, RS, Bencko, V, Foretova, L, Janout, V, Boffetta, P, Peters, S, Vermeulen, R, Kromhout, H, Brüning, T & Olsson, AC 2016, 'Lung cancer among firefighters: Smoking-adjusted risk estimates in a pooled analysis of case-control studies', Journal of Occupational and Environmental Medicine, vol. 58, no. 11, pp. 1137-1143. https://doi.org/10.1097/JOM.0000000000000878

TY - JOUR

T1 - Lung cancer among firefighters

T2 - Smoking-adjusted risk estimates in a pooled analysis of case-control studies

AU - Bigert, Carolina

AU - Gustavsson, Per

AU - Straif, Kurt

AU - Taeger, Dirk

AU - Pesch, Beate

AU - Kendzia, Benjamin

AU - Schüz, Joachim

AU - Stücker, Isabelle

AU - Guida, Florence

AU - Brüske, Irene

AU - Wichmann, Heinz Erich

AU - Pesatori, Angela C.

AU - Landi, Maria Teresa

AU - Caporaso, Neil

AU - Tse, Lap Ah

AU - Yu, Ignatius Tak Sun

AU - Siemiatycki, Jack

AU - Lavoué, Jérôme

AU - Richiardi, Lorenzo

AU - Mirabelli, Dario

AU - Simonato, Lorenzo

AU - Jöckel, Karl Heinz

AU - Ahrens, Wolfgang

AU - Pohlabeln, Hermann

AU - Tardón, Adonina

AU - Zaridze, David

AU - Field, John K.

AU - Mannetje, Andrea'T

AU - Pearce, Neil

AU - McLaughlin, John

AU - Demers, Paul

AU - Szeszenia-Dabrowska, Neonila

AU - Lissowska, Jolanta

AU - Rudnai, Peter

AU - Fabianova, Eleonora

AU - Dumitru, Rodica Stanescu

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Boffetta, Paolo

AU - Peters, Susan

AU - Vermeulen, Roel

AU - Kromhout, Hans

AU - Brüning, Thomas

AU - Olsson, Ann C.

PY - 2016/11/28

Y1 - 2016/11/28

N2 - Objectives: The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking. Methods: We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk of lung cancer. Results: There was no increased lung cancer risk overall or by specific cell type among firefighters (n=190), neither before nor after smoking adjustment. We observed no significant exposure-response relationship in terms of work duration. Conclusions: We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter.

AB - Objectives: The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking. Methods: We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk of lung cancer. Results: There was no increased lung cancer risk overall or by specific cell type among firefighters (n=190), neither before nor after smoking adjustment. We observed no significant exposure-response relationship in terms of work duration. Conclusions: We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter.

UR - https://www.scopus.com/pages/publications/84995890897

U2 - 10.1097/JOM.0000000000000878

DO - 10.1097/JOM.0000000000000878

M3 - Article

C2 - 27820764

AN - SCOPUS:84995890897

SN - 1076-2752

VL - 58

SP - 1137

EP - 1143

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

IS - 11

ER -

Lung cancer among firefighters: Smoking-adjusted risk estimates in a pooled analysis of case-control studies

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