Lymphocyte Subsets in the Neonates of Preeclamptic Mothers

DAVID A. BAKER; CHAUDHRY HAMEED; NERGESH TEJANI; JOANNE THOMAS; RAYMOND DATTWYLER

doi:10.1111/j.1600-0897.1987.tb00129.x

Lymphocyte Subsets in the Neonates of Preeclamptic Mothers

DAVID A. BAKER
, CHAUDHRY HAMEED
, NERGESH TEJANI
, JOANNE THOMAS
, RAYMOND DATTWYLER

Obstetrics and Gynecology

Nassau University Medical Center
Stony Brook University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

ABSTRACT: With the aid of specific monoclonal antibodies, indirect immunofluorescence, and flow cytometry, peripheral blood lymphocyte populations were studied in 12 preeclamptic mothers and compared with those of ten normal patients at term. As well, lymphocyte subsets from newborns of these preeclamptic mothers and ten normal patients at term were studied. Lymphocytes were labelled with murine monoclonal antibodies directed against T cells and subsets of helper cells, suppressor/cytotoxic cells and natural killer cells. Cord blood lymphocytes of neonates from preeclamptic mothers showed a statistically significant reduction of total T cells, helper cells, and natural killer cells as compared to control. A significant reduction in helper/ suppressor ratio was also observed. It is hypothesized that the differences in the immune system of the neonates in the preeclamptic group may be due to the stress of intrauterine malnutrition secondary to uteroplacental insufficiency. 1987 Munksgaard

Original language	English
Pages (from-to)	107-109
Number of pages	3
Journal	American Journal of Reproductive Immunology
Volume	14
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-0897.1987.tb00129.x
State	Published - Aug 1987

Keywords

preeclampsia
T cell subsets

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10.1111/j.1600-0897.1987.tb00129.x

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title = "Lymphocyte Subsets in the Neonates of Preeclamptic Mothers",

abstract = "ABSTRACT: With the aid of specific monoclonal antibodies, indirect immunofluorescence, and flow cytometry, peripheral blood lymphocyte populations were studied in 12 preeclamptic mothers and compared with those of ten normal patients at term. As well, lymphocyte subsets from newborns of these preeclamptic mothers and ten normal patients at term were studied. Lymphocytes were labelled with murine monoclonal antibodies directed against T cells and subsets of helper cells, suppressor/cytotoxic cells and natural killer cells. Cord blood lymphocytes of neonates from preeclamptic mothers showed a statistically significant reduction of total T cells, helper cells, and natural killer cells as compared to control. A significant reduction in helper/ suppressor ratio was also observed. It is hypothesized that the differences in the immune system of the neonates in the preeclamptic group may be due to the stress of intrauterine malnutrition secondary to uteroplacental insufficiency. 1987 Munksgaard",

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AU - BAKER, DAVID A.

AU - HAMEED, CHAUDHRY

AU - TEJANI, NERGESH

AU - THOMAS, JOANNE

AU - DATTWYLER, RAYMOND

PY - 1987/8

Y1 - 1987/8

N2 - ABSTRACT: With the aid of specific monoclonal antibodies, indirect immunofluorescence, and flow cytometry, peripheral blood lymphocyte populations were studied in 12 preeclamptic mothers and compared with those of ten normal patients at term. As well, lymphocyte subsets from newborns of these preeclamptic mothers and ten normal patients at term were studied. Lymphocytes were labelled with murine monoclonal antibodies directed against T cells and subsets of helper cells, suppressor/cytotoxic cells and natural killer cells. Cord blood lymphocytes of neonates from preeclamptic mothers showed a statistically significant reduction of total T cells, helper cells, and natural killer cells as compared to control. A significant reduction in helper/ suppressor ratio was also observed. It is hypothesized that the differences in the immune system of the neonates in the preeclamptic group may be due to the stress of intrauterine malnutrition secondary to uteroplacental insufficiency. 1987 Munksgaard

AB - ABSTRACT: With the aid of specific monoclonal antibodies, indirect immunofluorescence, and flow cytometry, peripheral blood lymphocyte populations were studied in 12 preeclamptic mothers and compared with those of ten normal patients at term. As well, lymphocyte subsets from newborns of these preeclamptic mothers and ten normal patients at term were studied. Lymphocytes were labelled with murine monoclonal antibodies directed against T cells and subsets of helper cells, suppressor/cytotoxic cells and natural killer cells. Cord blood lymphocytes of neonates from preeclamptic mothers showed a statistically significant reduction of total T cells, helper cells, and natural killer cells as compared to control. A significant reduction in helper/ suppressor ratio was also observed. It is hypothesized that the differences in the immune system of the neonates in the preeclamptic group may be due to the stress of intrauterine malnutrition secondary to uteroplacental insufficiency. 1987 Munksgaard

KW - preeclampsia

KW - T cell subsets

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JO - American Journal of Reproductive Immunology

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Lymphocyte Subsets in the Neonates of Preeclamptic Mothers

Abstract

Keywords

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