Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain

Louis N. Manganas; Xueying Zhang; Yao Li; Raphael D. Hazel; S. David Smith; Mark E. Wagshul; Fritz Henn; Helene Benveniste; Petar M. Djurić; Grigori Enikolopov; Mirjana Maletić-Savatić

doi:10.1126/science.1147851

Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain

Louis N. Manganas
, Xueying Zhang
, Yao Li
, Raphael D. Hazel
, S. David Smith
, Mark E. Wagshul
, Fritz Henn
, Helene Benveniste
, Petar M. Djurić
, Grigori Enikolopov
, Mirjana Maletić-Savatić

Stony Brook University
Cold Spring Harbor Laboratory
Brookhaven National Laboratory

Research output: Contribution to journal › Article › peer-review

387 Scopus citations

Abstract

The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.

Original language	English
Pages (from-to)	980-985
Number of pages	6
Journal	Science
Volume	318
Issue number	5852
DOIs	https://doi.org/10.1126/science.1147851
State	Published - Nov 2 2007

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title = "Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain",

abstract = "The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.",

author = "Manganas, \{Louis N.\} and Xueying Zhang and Yao Li and Hazel, \{Raphael D.\} and Smith, \{S. David\} and Wagshul, \{Mark E.\} and Fritz Henn and Helene Benveniste and Djuri{\'c}, \{Petar M.\} and Grigori Enikolopov and Mirjana Maleti{\'c}-Savati{\'c}",

year = "2007",

month = nov,

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doi = "10.1126/science.1147851",

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T1 - Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain

AU - Manganas, Louis N.

AU - Zhang, Xueying

AU - Li, Yao

AU - Hazel, Raphael D.

AU - Smith, S. David

AU - Wagshul, Mark E.

AU - Henn, Fritz

AU - Benveniste, Helene

AU - Djurić, Petar M.

AU - Enikolopov, Grigori

AU - Maletić-Savatić, Mirjana

PY - 2007/11/2

Y1 - 2007/11/2

N2 - The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.

AB - The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.

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DO - 10.1126/science.1147851

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SP - 980

EP - 985

JO - Science

JF - Science

IS - 5852

ER -

Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain

Abstract

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