Mammalian neutral sphingomyelinases: Regulation and roles in cell signaling responses

Bill X. Wu; Christopher J. Clarke; Yusuf A. Hannun

doi:10.1007/s12017-010-8120-z

Mammalian neutral sphingomyelinases: Regulation and roles in cell signaling responses

Medical University of South Carolina

Research output: Contribution to journal › Review article › peer-review

140 Scopus citations

Abstract

Ceramide, a bioactive lipid, has been extensively studied and identified as an essential bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase (SMase), (EC 3.1.4.12) catalyzes the cleavage of the phosphodiester bond in sphingomyelin (SM) to form ceramide and phosphocholine. In mammals, three Mg²⁺-dependent neutral SMases termed nSMase1, nSMase2 and nSMase3 have been identified. Among the three enzymes, nSMase2 is the most studied and has been implicated in multiple physiological responses including cell growth arrest, apoptosis, development and inflammation. In this review, we summarize recent findings for the cloned nSMases and discuss the insights for their roles in regulation ceramide metabolism and cellular signaling pathway.

Original language	English
Pages (from-to)	320-330
Number of pages	11
Journal	NeuroMolecular Medicine
Volume	12
Issue number	4
DOIs	https://doi.org/10.1007/s12017-010-8120-z
State	Published - Dec 2010

Keywords

Bioactive lipids
Ceramide
Neutral sphingomyelinase
nSMase2
SM
Sphingolipid

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10.1007/s12017-010-8120-z

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title = "Mammalian neutral sphingomyelinases: Regulation and roles in cell signaling responses",

abstract = "Ceramide, a bioactive lipid, has been extensively studied and identified as an essential bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase (SMase), (EC 3.1.4.12) catalyzes the cleavage of the phosphodiester bond in sphingomyelin (SM) to form ceramide and phosphocholine. In mammals, three Mg2+-dependent neutral SMases termed nSMase1, nSMase2 and nSMase3 have been identified. Among the three enzymes, nSMase2 is the most studied and has been implicated in multiple physiological responses including cell growth arrest, apoptosis, development and inflammation. In this review, we summarize recent findings for the cloned nSMases and discuss the insights for their roles in regulation ceramide metabolism and cellular signaling pathway.",

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author = "Wu, \{Bill X.\} and Clarke, \{Christopher J.\} and Hannun, \{Yusuf A.\}",

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T2 - Regulation and roles in cell signaling responses

AU - Wu, Bill X.

AU - Clarke, Christopher J.

AU - Hannun, Yusuf A.

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N2 - Ceramide, a bioactive lipid, has been extensively studied and identified as an essential bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase (SMase), (EC 3.1.4.12) catalyzes the cleavage of the phosphodiester bond in sphingomyelin (SM) to form ceramide and phosphocholine. In mammals, three Mg2+-dependent neutral SMases termed nSMase1, nSMase2 and nSMase3 have been identified. Among the three enzymes, nSMase2 is the most studied and has been implicated in multiple physiological responses including cell growth arrest, apoptosis, development and inflammation. In this review, we summarize recent findings for the cloned nSMases and discuss the insights for their roles in regulation ceramide metabolism and cellular signaling pathway.

AB - Ceramide, a bioactive lipid, has been extensively studied and identified as an essential bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase (SMase), (EC 3.1.4.12) catalyzes the cleavage of the phosphodiester bond in sphingomyelin (SM) to form ceramide and phosphocholine. In mammals, three Mg2+-dependent neutral SMases termed nSMase1, nSMase2 and nSMase3 have been identified. Among the three enzymes, nSMase2 is the most studied and has been implicated in multiple physiological responses including cell growth arrest, apoptosis, development and inflammation. In this review, we summarize recent findings for the cloned nSMases and discuss the insights for their roles in regulation ceramide metabolism and cellular signaling pathway.

KW - Bioactive lipids

KW - Ceramide

KW - Neutral sphingomyelinase

KW - nSMase2

KW - SM

KW - Sphingolipid

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U2 - 10.1007/s12017-010-8120-z

DO - 10.1007/s12017-010-8120-z

M3 - Review article

C2 - 20552297

AN - SCOPUS:78649802553

SN - 1535-1084

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SP - 320

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JO - NeuroMolecular Medicine

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ER -

Mammalian neutral sphingomyelinases: Regulation and roles in cell signaling responses

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