Abstract
A marginal model for binomial data where the experimental units involving one or two random factors is presented. Two variance-covariance models are derived based on the multiplicative error formulation. The parameters of mean and variance components are estimated using quasi-likelihood and method of moments, respectively. The model is applied to analyzing multivariate overdispersed binomial data from a developmental toxicity experiment.
| Original language | English |
|---|---|
| Pages (from-to) | 440-450 |
| Number of pages | 11 |
| Journal | Journal of Agricultural, Biological, and Environmental Statistics |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1997 |
Keywords
- Extra-binomial variation
- Mixed effects model
- Nested design
- Random effects model
- Two-way layout
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