Mass spectrometry methods for the analysis of bioactive sphingolipids: A high- performance liquid chromatography/tandem mass spectrometry approach

Jacek Bielawski; Motohiro Tani; Yusuf A. Hannun

doi:10.1201/9780849381423

Mass spectrometry methods for the analysis of bioactive sphingolipids: A high- performance liquid chromatography/tandem mass spectrometry approach

Jacek Bielawski
, Motohiro Tani
, Yusuf A. Hannun

Cancer Center

Medical University of South Carolina

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Sphingolipids (SPL), the general name for lipids containing a sphingoid long-chain base, are one of the most chemically and functionally diverse classes of biomolecules [1]. Sphingomyelin (SM) and glycosphingolipids (GSPL) constitute the major complex SPL in mammalian cells, both of which contain Cer as a lipid portion and phosphorylcholine or sugars, respectively, as a hydrophilic moiety. Cer, composed of a sphingoid base (SB) and an amide-linked fatty acid (FA), serves as the precursor for almost all SPL [1].

Original language	English
Title of host publication	Lipid-Mediated Signaling
Publisher	CRC Press
Pages	177-198
Number of pages	22
ISBN (Electronic)	9780849381423
ISBN (Print)	9780849381416
DOIs	https://doi.org/10.1201/9780849381423
State	Published - Jan 1 2010

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abstract = "Sphingolipids (SPL), the general name for lipids containing a sphingoid long-chain base, are one of the most chemically and functionally diverse classes of biomolecules [1]. Sphingomyelin (SM) and glycosphingolipids (GSPL) constitute the major complex SPL in mammalian cells, both of which contain Cer as a lipid portion and phosphorylcholine or sugars, respectively, as a hydrophilic moiety. Cer, composed of a sphingoid base (SB) and an amide-linked fatty acid (FA), serves as the precursor for almost all SPL [1].",

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AU - Tani, Motohiro

AU - Hannun, Yusuf A.

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N2 - Sphingolipids (SPL), the general name for lipids containing a sphingoid long-chain base, are one of the most chemically and functionally diverse classes of biomolecules [1]. Sphingomyelin (SM) and glycosphingolipids (GSPL) constitute the major complex SPL in mammalian cells, both of which contain Cer as a lipid portion and phosphorylcholine or sugars, respectively, as a hydrophilic moiety. Cer, composed of a sphingoid base (SB) and an amide-linked fatty acid (FA), serves as the precursor for almost all SPL [1].

AB - Sphingolipids (SPL), the general name for lipids containing a sphingoid long-chain base, are one of the most chemically and functionally diverse classes of biomolecules [1]. Sphingomyelin (SM) and glycosphingolipids (GSPL) constitute the major complex SPL in mammalian cells, both of which contain Cer as a lipid portion and phosphorylcholine or sugars, respectively, as a hydrophilic moiety. Cer, composed of a sphingoid base (SB) and an amide-linked fatty acid (FA), serves as the precursor for almost all SPL [1].

UR - https://www.scopus.com/pages/publications/85049267446

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DO - 10.1201/9780849381423

M3 - Chapter

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SP - 177

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BT - Lipid-Mediated Signaling

PB - CRC Press

ER -

Mass spectrometry methods for the analysis of bioactive sphingolipids: A high- performance liquid chromatography/tandem mass spectrometry approach

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