Mechanisms of age-related cognitive change and targets for intervention: Epigenetics

Kenneth S. Kosik; Peter R. Rapp; Naftali Raz; Scott A. Small; J. David Sweatt; Li Huei Tsai

doi:10.1093/gerona/gls110

Mechanisms of age-related cognitive change and targets for intervention: Epigenetics

Kenneth S. Kosik
, Peter R. Rapp
, Naftali Raz
, Scott A. Small
, J. David Sweatt
, Li Huei Tsai

Psychology

University of California at Santa Barbara
National Institutes of Health
Columbia University
University of Alabama at Birmingham
Broad Institute
Massachusetts Institute of Technology

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Epigenetic regulation of gene expression plays an important role in learning and memory, mediating the influence of experience on critical mechanisms of plasticity. Speakers in the opening session of the Summit reviewed research on epigenetic contributions to age-related cognitive decline and discussed strategies for the development of interventions targeting epigenetic mechanisms. The presentations focused on experience-dependent DNA methylation, the regulatory role of microRNAs, histone deacetylases as potential therapeutic targets, and strategies for exploring epigenetic contributions to the aging of brain and cognition. This session established useful mileposts for gaging progress in this rapidly advancing area of research.

Original language	English
Pages (from-to)	741-746
Number of pages	6
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	67 A
Issue number	7
DOIs	https://doi.org/10.1093/gerona/gls110
State	Published - Jun 15 2012

Keywords

Cognitive changes
Epigenetics

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10.1093/gerona/gls110

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abstract = "Epigenetic regulation of gene expression plays an important role in learning and memory, mediating the influence of experience on critical mechanisms of plasticity. Speakers in the opening session of the Summit reviewed research on epigenetic contributions to age-related cognitive decline and discussed strategies for the development of interventions targeting epigenetic mechanisms. The presentations focused on experience-dependent DNA methylation, the regulatory role of microRNAs, histone deacetylases as potential therapeutic targets, and strategies for exploring epigenetic contributions to the aging of brain and cognition. This session established useful mileposts for gaging progress in this rapidly advancing area of research.",

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T2 - Epigenetics

AU - Kosik, Kenneth S.

AU - Rapp, Peter R.

AU - Raz, Naftali

AU - Small, Scott A.

AU - Sweatt, J. David

AU - Tsai, Li Huei

PY - 2012/6/15

Y1 - 2012/6/15

N2 - Epigenetic regulation of gene expression plays an important role in learning and memory, mediating the influence of experience on critical mechanisms of plasticity. Speakers in the opening session of the Summit reviewed research on epigenetic contributions to age-related cognitive decline and discussed strategies for the development of interventions targeting epigenetic mechanisms. The presentations focused on experience-dependent DNA methylation, the regulatory role of microRNAs, histone deacetylases as potential therapeutic targets, and strategies for exploring epigenetic contributions to the aging of brain and cognition. This session established useful mileposts for gaging progress in this rapidly advancing area of research.

AB - Epigenetic regulation of gene expression plays an important role in learning and memory, mediating the influence of experience on critical mechanisms of plasticity. Speakers in the opening session of the Summit reviewed research on epigenetic contributions to age-related cognitive decline and discussed strategies for the development of interventions targeting epigenetic mechanisms. The presentations focused on experience-dependent DNA methylation, the regulatory role of microRNAs, histone deacetylases as potential therapeutic targets, and strategies for exploring epigenetic contributions to the aging of brain and cognition. This session established useful mileposts for gaging progress in this rapidly advancing area of research.

KW - Cognitive changes

KW - Epigenetics

UR - https://www.scopus.com/pages/publications/84863647710

U2 - 10.1093/gerona/gls110

DO - 10.1093/gerona/gls110

M3 - Article

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AN - SCOPUS:84863647710

SN - 1079-5006

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JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 7

ER -

Mechanisms of age-related cognitive change and targets for intervention: Epigenetics

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Keywords

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