Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group

André Zugman; Anita Harrewijn; Elise M. Cardinale; Hannah Zwiebel; Gabrielle F. Freitag; Katy E. Werwath; Janna M. Bas-Hoogendam; Nynke A. Groenewold; Moji Aghajani; Kevin Hilbert; Narcis Cardoner; Daniel Porta-Casteràs; Savannah Gosnell; Ramiro Salas; Karina S. Blair; James R. Blair; Mira Z. Hammoud; Mohammed Milad; Katie Burkhouse; K. Luan Phan; Heidi K. Schroeder; Jeffrey R. Strawn; Katja Beesdo-Baum; Sophia I. Thomopoulos; Hans J. Grabe; Sandra Van der Auwera; Katharina Wittfeld; Jared A. Nielsen; Randy Buckner; Jordan W. Smoller; Benson Mwangi; Jair C. Soares; Mon Ju Wu; Giovana B. Zunta-Soares; Andrea P. Jackowski; Pedro M. Pan; Giovanni A. Salum; Michal Assaf; Gretchen J. Diefenbach; Paolo Brambilla; Eleonora Maggioni; David Hofmann; Thomas Straube; Carmen Andreescu; Rachel Berta; Erica Tamburo; Rebecca Price; Gisele G. Manfro; Hugo D. Critchley; Elena Makovac; Matteo Mancini; Frances Meeten; Cristina Ottaviani; Federica Agosta; Elisa Canu; Camilla Cividini; Massimo Filippi; Milutin Kostić; Ana Munjiza; Courtney A. Filippi; Ellen Leibenluft; Bianca A.V. Alberton; Nicholas L. Balderston; Monique Ernst; Christian Grillon; Lilianne R. Mujica-Parodi; Helena van Nieuwenhuizen; Gregory A. Fonzo; Martin P. Paulus; Murray B. Stein; Raquel E. Gur; Ruben C. Gur; Antonia N. Kaczkurkin; Bart Larsen; Theodore D. Satterthwaite; Jennifer Harper; Michael Myers; Michael T. Perino; Qiongru Yu; Chad M. Sylvester; Dick J. Veltman; Ulrike Lueken; Nic J.A. Van der Wee; Dan J. Stein; Neda Jahanshad; Paul M. Thompson; Daniel S. Pine; Anderson M. Winkler

doi:10.1002/hbm.25096

Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group

André Zugman
, Anita Harrewijn
, Elise M. Cardinale
, Hannah Zwiebel
, Gabrielle F. Freitag
, Katy E. Werwath
, Janna M. Bas-Hoogendam
, Nynke A. Groenewold
, Moji Aghajani
, Kevin Hilbert
, Narcis Cardoner
, Daniel Porta-Casteràs
, Savannah Gosnell
, Ramiro Salas
, Karina S. Blair
, James R. Blair
, Mira Z. Hammoud
, Mohammed Milad
, Katie Burkhouse
, K. Luan Phan

Heidi K. Schroeder, Jeffrey R. Strawn, Katja Beesdo-Baum, Sophia I. Thomopoulos, Hans J. Grabe, Sandra Van der Auwera, Katharina Wittfeld, Jared A. Nielsen, Randy Buckner, Jordan W. Smoller, Benson Mwangi, Jair C. Soares, Mon Ju Wu, Giovana B. Zunta-Soares, Andrea P. Jackowski, Pedro M. Pan, Giovanni A. Salum, Michal Assaf, Gretchen J. Diefenbach, Paolo Brambilla, Eleonora Maggioni, David Hofmann, Thomas Straube, Carmen Andreescu, Rachel Berta, Erica Tamburo, Rebecca Price, Gisele G. Manfro, Hugo D. Critchley, Elena Makovac, Matteo Mancini, Frances Meeten, Cristina Ottaviani, Federica Agosta, Elisa Canu, Camilla Cividini, Massimo Filippi, Milutin Kostić, Ana Munjiza, Courtney A. Filippi, Ellen Leibenluft, Bianca A.V. Alberton, Nicholas L. Balderston, Monique Ernst, Christian Grillon, Lilianne R. Mujica-Parodi, Helena van Nieuwenhuizen, Gregory A. Fonzo, Martin P. Paulus, Murray B. Stein, Raquel E. Gur, Ruben C. Gur, Antonia N. Kaczkurkin, Bart Larsen, Theodore D. Satterthwaite, Jennifer Harper, Michael Myers, Michael T. Perino, Qiongru Yu, Chad M. Sylvester, Dick J. Veltman, Ulrike Lueken, Nic J.A. Van der Wee, Dan J. Stein, Neda Jahanshad, Paul M. Thompson, Daniel S. Pine, Anderson M. Winkler

Dept of Biomedical Engineering

National Institutes of Health
Leiden University
University of Cape Town
VU University Medical Center
Humboldt University of Berlin
CIBER Enfermedades Respiratorias
Autonomous University of Barcelona
Centro de Investigación Biomédica En Red de Salud Mental
Baylor College of Medicine
Boys Town National Research Hospital
New York University
University of Illinois at Chicago
Ohio State University
University of Cincinnati
Technische Universität Dresden
University of Southern California
University of Greifswald
German Center for Neurodegenerative Diseases
Harvard University
Massachusetts General Hospital
University of Texas Health Science Center at Houston
Universidade Federal de São Paulo
Universidade Federal do Rio Grande do Sul
Institute of Living
Yale University
IRCCS Fondazione Ca'Granda – Ospedale Maggiore Policlinico - Milano
University of Münster
University of Pittsburgh
University of Sussex
King's College London
University of Rome La Sapienza
San Raffaele Scientific Institute
Vita-Salute San Raffaele University
University of Belgrade
Universidade Tecnológica Federal do Paraná
University of Pennsylvania
Stony Brook University
University of Texas at Austin
Laureate Institute for Brain Research
University of California at San Diego
Washington University St. Louis

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.

Original language	English
Pages (from-to)	255-277
Number of pages	23
Journal	Human Brain Mapping
Volume	43
Issue number	1
DOIs	https://doi.org/10.1002/hbm.25096
State	Published - Jan 2022

Keywords

data sharing
generalized anxiety disorder
mega-analyses
meta-analyses
neuroimaging

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10.1002/hbm.25096

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Zugman, A., Harrewijn, A., Cardinale, E. M., Zwiebel, H., Freitag, G. F., Werwath, K. E., Bas-Hoogendam, J. M., Groenewold, N. A., Aghajani, M., Hilbert, K., Cardoner, N., Porta-Casteràs, D., Gosnell, S., Salas, R., Blair, K. S., Blair, J. R., Hammoud, M. Z., Milad, M., Burkhouse, K., ... Winkler, A. M. (2022). Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group. Human Brain Mapping, 43(1), 255-277. https://doi.org/10.1002/hbm.25096

@article{62b38626726240d7ad65769028b0749b,

title = "Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group",

abstract = "The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.",

keywords = "data sharing, generalized anxiety disorder, mega-analyses, meta-analyses, neuroimaging",

author = "Andr{\'e} Zugman and Anita Harrewijn and Cardinale, \{Elise M.\} and Hannah Zwiebel and Freitag, \{Gabrielle F.\} and Werwath, \{Katy E.\} and Bas-Hoogendam, \{Janna M.\} and Groenewold, \{Nynke A.\} and Moji Aghajani and Kevin Hilbert and Narcis Cardoner and Daniel Porta-Caster{\`a}s and Savannah Gosnell and Ramiro Salas and Blair, \{Karina S.\} and Blair, \{James R.\} and Hammoud, \{Mira Z.\} and Mohammed Milad and Katie Burkhouse and Phan, \{K. Luan\} and Schroeder, \{Heidi K.\} and Strawn, \{Jeffrey R.\} and Katja Beesdo-Baum and Thomopoulos, \{Sophia I.\} and Grabe, \{Hans J.\} and \{Van der Auwera\}, Sandra and Katharina Wittfeld and Nielsen, \{Jared A.\} and Randy Buckner and Smoller, \{Jordan W.\} and Benson Mwangi and Soares, \{Jair C.\} and Wu, \{Mon Ju\} and Zunta-Soares, \{Giovana B.\} and Jackowski, \{Andrea P.\} and Pan, \{Pedro M.\} and Salum, \{Giovanni A.\} and Michal Assaf and Diefenbach, \{Gretchen J.\} and Paolo Brambilla and Eleonora Maggioni and David Hofmann and Thomas Straube and Carmen Andreescu and Rachel Berta and Erica Tamburo and Rebecca Price and Manfro, \{Gisele G.\} and Critchley, \{Hugo D.\} and Elena Makovac and Matteo Mancini and Frances Meeten and Cristina Ottaviani and Federica Agosta and Elisa Canu and Camilla Cividini and Massimo Filippi and Milutin Kosti{\'c} and Ana Munjiza and Filippi, \{Courtney A.\} and Ellen Leibenluft and Alberton, \{Bianca A.V.\} and Balderston, \{Nicholas L.\} and Monique Ernst and Christian Grillon and Mujica-Parodi, \{Lilianne R.\} and \{van Nieuwenhuizen\}, Helena and Fonzo, \{Gregory A.\} and Paulus, \{Martin P.\} and Stein, \{Murray B.\} and Gur, \{Raquel E.\} and Gur, \{Ruben C.\} and Kaczkurkin, \{Antonia N.\} and Bart Larsen and Satterthwaite, \{Theodore D.\} and Jennifer Harper and Michael Myers and Perino, \{Michael T.\} and Qiongru Yu and Sylvester, \{Chad M.\} and Veltman, \{Dick J.\} and Ulrike Lueken and \{Van der Wee\}, \{Nic J.A.\} and Stein, \{Dan J.\} and Neda Jahanshad and Thompson, \{Paul M.\} and Pine, \{Daniel S.\} and Winkler, \{Anderson M.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.",

year = "2022",

month = jan,

doi = "10.1002/hbm.25096",

language = "English",

volume = "43",

pages = "255--277",

journal = "Human Brain Mapping",

issn = "1065-9471",

number = "1",

}

Zugman, A, Harrewijn, A, Cardinale, EM, Zwiebel, H, Freitag, GF, Werwath, KE, Bas-Hoogendam, JM, Groenewold, NA, Aghajani, M, Hilbert, K, Cardoner, N, Porta-Casteràs, D, Gosnell, S, Salas, R, Blair, KS, Blair, JR, Hammoud, MZ, Milad, M, Burkhouse, K, Phan, KL, Schroeder, HK, Strawn, JR, Beesdo-Baum, K, Thomopoulos, SI, Grabe, HJ, Van der Auwera, S, Wittfeld, K, Nielsen, JA, Buckner, R, Smoller, JW, Mwangi, B, Soares, JC, Wu, MJ, Zunta-Soares, GB, Jackowski, AP, Pan, PM, Salum, GA, Assaf, M, Diefenbach, GJ, Brambilla, P, Maggioni, E, Hofmann, D, Straube, T, Andreescu, C, Berta, R, Tamburo, E, Price, R, Manfro, GG, Critchley, HD, Makovac, E, Mancini, M, Meeten, F, Ottaviani, C, Agosta, F, Canu, E, Cividini, C, Filippi, M, Kostić, M, Munjiza, A, Filippi, CA, Leibenluft, E, Alberton, BAV, Balderston, NL, Ernst, M, Grillon, C, Mujica-Parodi, LR, van Nieuwenhuizen, H, Fonzo, GA, Paulus, MP, Stein, MB, Gur, RE, Gur, RC, Kaczkurkin, AN, Larsen, B, Satterthwaite, TD, Harper, J, Myers, M, Perino, MT, Yu, Q, Sylvester, CM, Veltman, DJ, Lueken, U, Van der Wee, NJA, Stein, DJ, Jahanshad, N, Thompson, PM, Pine, DS & Winkler, AM 2022, 'Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group', Human Brain Mapping, vol. 43, no. 1, pp. 255-277. https://doi.org/10.1002/hbm.25096

TY - JOUR

T1 - Mega-analysis methods in ENIGMA

T2 - The experience of the generalized anxiety disorder working group

AU - Zugman, André

AU - Harrewijn, Anita

AU - Cardinale, Elise M.

AU - Zwiebel, Hannah

AU - Freitag, Gabrielle F.

AU - Werwath, Katy E.

AU - Bas-Hoogendam, Janna M.

AU - Groenewold, Nynke A.

AU - Aghajani, Moji

AU - Hilbert, Kevin

AU - Cardoner, Narcis

AU - Porta-Casteràs, Daniel

AU - Gosnell, Savannah

AU - Salas, Ramiro

AU - Blair, Karina S.

AU - Blair, James R.

AU - Hammoud, Mira Z.

AU - Milad, Mohammed

AU - Burkhouse, Katie

AU - Phan, K. Luan

AU - Schroeder, Heidi K.

AU - Strawn, Jeffrey R.

AU - Beesdo-Baum, Katja

AU - Thomopoulos, Sophia I.

AU - Grabe, Hans J.

AU - Van der Auwera, Sandra

AU - Wittfeld, Katharina

AU - Nielsen, Jared A.

AU - Buckner, Randy

AU - Smoller, Jordan W.

AU - Mwangi, Benson

AU - Soares, Jair C.

AU - Wu, Mon Ju

AU - Zunta-Soares, Giovana B.

AU - Jackowski, Andrea P.

AU - Pan, Pedro M.

AU - Salum, Giovanni A.

AU - Assaf, Michal

AU - Diefenbach, Gretchen J.

AU - Brambilla, Paolo

AU - Maggioni, Eleonora

AU - Hofmann, David

AU - Straube, Thomas

AU - Andreescu, Carmen

AU - Berta, Rachel

AU - Tamburo, Erica

AU - Price, Rebecca

AU - Manfro, Gisele G.

AU - Critchley, Hugo D.

AU - Makovac, Elena

AU - Mancini, Matteo

AU - Meeten, Frances

AU - Ottaviani, Cristina

AU - Agosta, Federica

AU - Canu, Elisa

AU - Cividini, Camilla

AU - Filippi, Massimo

AU - Kostić, Milutin

AU - Munjiza, Ana

AU - Filippi, Courtney A.

AU - Leibenluft, Ellen

AU - Alberton, Bianca A.V.

AU - Balderston, Nicholas L.

AU - Ernst, Monique

AU - Grillon, Christian

AU - Mujica-Parodi, Lilianne R.

AU - van Nieuwenhuizen, Helena

AU - Fonzo, Gregory A.

AU - Paulus, Martin P.

AU - Stein, Murray B.

AU - Gur, Raquel E.

AU - Gur, Ruben C.

AU - Kaczkurkin, Antonia N.

AU - Larsen, Bart

AU - Satterthwaite, Theodore D.

AU - Harper, Jennifer

AU - Myers, Michael

AU - Perino, Michael T.

AU - Yu, Qiongru

AU - Sylvester, Chad M.

AU - Veltman, Dick J.

AU - Lueken, Ulrike

AU - Van der Wee, Nic J.A.

AU - Stein, Dan J.

AU - Jahanshad, Neda

AU - Thompson, Paul M.

AU - Pine, Daniel S.

AU - Winkler, Anderson M.

PY - 2022/1

Y1 - 2022/1

N2 - The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.

AB - The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.

KW - data sharing

KW - generalized anxiety disorder

KW - mega-analyses

KW - meta-analyses

KW - neuroimaging

UR - https://www.scopus.com/pages/publications/85083703055

U2 - 10.1002/hbm.25096

DO - 10.1002/hbm.25096

M3 - Review article

C2 - 32596977

AN - SCOPUS:85083703055

SN - 1065-9471

VL - 43

SP - 255

EP - 277

JO - Human Brain Mapping

JF - Human Brain Mapping

IS - 1

ER -

Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group

Abstract

Keywords

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