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MEMS-based silicon ultrasonic twin-nozzle nebulizer for inhalation drug delivery

  • R. W. Mao
  • , S. K. Lin
  • , S. C. Tsai
  • , M. Brenner
  • , S. Mahon
  • , G. Boss
  • , G. Smaldone
  • , C. S. Tsai
  • University of California at Irvine
  • University of California at San Diego
  • National Taiwan University

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

A versatile silicon-based ultrasonic nebulizer that utilizes a twin-nozzle of multiple Fourier horns at 1-2 MHz drive frequencies has been realized to perform simultaneous aerosolization of cobinamide and magnesium thiosulfate drug solutions. The drive frequency of the individual nozzle for a desirable aerosol diameter was individually designed. Using the 2.0 MHz 4-Fourier horn twin-nozzle aerosols of the two drug solutions with mass median diameter (MMD) of 3.0±0.1μm and geometrical standard deviation (GSD) of 1.18±0.02 and total flow rate up to 400μL/min were produced.

Original languageEnglish
Title of host publicationIEEE International Ultrasonics Symposium, IUS
PublisherIEEE Computer Society
Pages742-744
Number of pages3
ISBN (Electronic)9781479970490
DOIs
StatePublished - Oct 20 2014
Event2014 IEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States
Duration: Sep 3 2014Sep 6 2014

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2014 IEEE International Ultrasonics Symposium, IUS 2014
Country/TerritoryUnited States
CityChicago
Period09/3/1409/6/14

Keywords

  • Inhalation Drug Delivery
  • Medicinal Aerosol Mixing
  • MEMS
  • Multiple Fourier-horn Nozzle
  • Twin-Nozzle Ultrasonic Nebulizer

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