@inproceedings{2e2244f10c744031bb51a2f234299115,
title = "Mesoscopic Fluorescence Imaging of Light Triggered Chemotherapeutic Release in a Cancer Spheroid Model",
abstract = "Peritoneal micrometastases (micromets) represent a significant clinical challenge across a wide spectrum of malignancies due to their aggressive progression and limited treatment efficacy. Liposomal Doxorubicin (Dox) is a viable drug formulation that improves the biodistribution and availability of the Dox chemotherapeutic, but is hindered by reduced release kinetics. Recent advances in this formulation enable light-triggered release of Dox from the liposome, resulting in targeted chemotherapy with reduced effects on the surrounding tissue. Light-triggered release of Dox at a tumor site functions in both a therapeutic and diagnostic capacity, as its inherent fluorescence allows for analysis of disease progression and can provide contrast for fluorescence-guided surgery. Here we examine light-triggered Dox as a contrast method for fluorescence-guided surgery by culturing the drug within a cancer spheroid model and imaging fluorescence with a laparoscopic system. Results from this method show promise in the use of Dox as a contrast marker for fluorescence-guided surgery in an imaging modality suitable for minimally-invasive micromet resection.",
author = "Elias Kluiszo and Rasel Ahmmed and Berna Aliu and Semra Aygun-Sunar and Luigi Belcastro and Matthew Willadsen and Kutscher, \{Hilliard L.\} and Lovell, \{Jonathan F.\} and Ulas Sunar",
note = "Publisher Copyright: {\textcopyright} SPIE.; 12th Molecular-Guided Surgery: Molecules, Devices, and Applications ; Conference date: 17-01-2026 Through 20-01-2026",
year = "2026",
month = mar,
day = "5",
doi = "10.1117/12.3081461",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Gibbs, \{Summer L.\} and Tichauer, \{Kenneth M.\}",
booktitle = "Molecular-Guided Surgery",
}