TY - GEN
T1 - Micro particle size measurements using modulated light scattering spectrum from SDOCT
AU - Yuan, Zhijia
AU - Wang, Zhenguo
AU - Pan, Yingtian
PY - 2007
Y1 - 2007
N2 - We report an experimental study based on spectral domain optical coherence tomography (SDOCT) to get depth resolved high-frequency modulated light scattering spectrum (LSS) for polystyrene micro particles with two different sizes: 7um and 15um in diameter. By filtering axial line signal with a Gaussian window, and doing IFFT for the filtered signal, we get the modulated LSS for the two types of particles in a specific depth range. Then by using Hilbert transform, we reconstruct the LSS for the two samples. The reconstructed LSS were then compared to the theoretical LSS results to confirm the sizes of these two different particles. This study demonstrates the potential of using this method to determine 3D distributed particles' size with sub micro resolution. It might also be developed to probe the size of nucleus in cells to help cellular morphology measurements.
AB - We report an experimental study based on spectral domain optical coherence tomography (SDOCT) to get depth resolved high-frequency modulated light scattering spectrum (LSS) for polystyrene micro particles with two different sizes: 7um and 15um in diameter. By filtering axial line signal with a Gaussian window, and doing IFFT for the filtered signal, we get the modulated LSS for the two types of particles in a specific depth range. Then by using Hilbert transform, we reconstruct the LSS for the two samples. The reconstructed LSS were then compared to the theoretical LSS results to confirm the sizes of these two different particles. This study demonstrates the potential of using this method to determine 3D distributed particles' size with sub micro resolution. It might also be developed to probe the size of nucleus in cells to help cellular morphology measurements.
UR - https://www.scopus.com/pages/publications/48749085746
U2 - 10.1109/NEBC.2007.4413294
DO - 10.1109/NEBC.2007.4413294
M3 - Conference contribution
AN - SCOPUS:48749085746
SN - 1424410339
SN - 9781424410330
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
SP - 92
EP - 93
BT - 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 33rd Annual Northeast Bioengineering Conference, NEBC
Y2 - 10 March 2007 through 11 March 2007
ER -