Microtubules Enhance Mesoscale Effective Diffusivity in the Crowded Metaphase Cytoplasm

Lina Carlini; Gregory P. Brittingham; Liam J. Holt; Tarun M. Kapoor

doi:10.1016/j.devcel.2020.07.020

Microtubules Enhance Mesoscale Effective Diffusivity in the Crowded Metaphase Cytoplasm

Lina Carlini
, Gregory P. Brittingham
, Liam J. Holt
, Tarun M. Kapoor

Laufer Center for Physical and Quantitative Biology

New York University
Rockefeller University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The mitotic spindle is composed of densely packed microtubules, yet mesoscale assemblies with sizes commensurate to the inter-filament spacing of the spindle need to diffuse across this structure. Carlini et al. report that metaphase microtubules help enhance the diffusive-like motion of 40 nm mesoscale particles, thereby equalizing mobility across the inhomogeneous metaphase cytoplasm.

Original language	English
Pages (from-to)	574-582.e4
Journal	Developmental Cell
Volume	54
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2020.07.020
State	Published - Sep 14 2020

Keywords

cell division
cytoplasm
diffusion
macromolecular crowding
metaphase
microtubules
mitotic spindle
nanoparticles

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10.1016/j.devcel.2020.07.020

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title = "Microtubules Enhance Mesoscale Effective Diffusivity in the Crowded Metaphase Cytoplasm",

abstract = "The mitotic spindle is composed of densely packed microtubules, yet mesoscale assemblies with sizes commensurate to the inter-filament spacing of the spindle need to diffuse across this structure. Carlini et al. report that metaphase microtubules help enhance the diffusive-like motion of 40 nm mesoscale particles, thereby equalizing mobility across the inhomogeneous metaphase cytoplasm.",

keywords = "cell division, cytoplasm, diffusion, macromolecular crowding, metaphase, microtubules, mitotic spindle, nanoparticles",

author = "Lina Carlini and Brittingham, \{Gregory P.\} and Holt, \{Liam J.\} and Kapoor, \{Tarun M.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

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doi = "10.1016/j.devcel.2020.07.020",

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AU - Carlini, Lina

AU - Brittingham, Gregory P.

AU - Holt, Liam J.

AU - Kapoor, Tarun M.

PY - 2020/9/14

Y1 - 2020/9/14

N2 - The mitotic spindle is composed of densely packed microtubules, yet mesoscale assemblies with sizes commensurate to the inter-filament spacing of the spindle need to diffuse across this structure. Carlini et al. report that metaphase microtubules help enhance the diffusive-like motion of 40 nm mesoscale particles, thereby equalizing mobility across the inhomogeneous metaphase cytoplasm.

AB - The mitotic spindle is composed of densely packed microtubules, yet mesoscale assemblies with sizes commensurate to the inter-filament spacing of the spindle need to diffuse across this structure. Carlini et al. report that metaphase microtubules help enhance the diffusive-like motion of 40 nm mesoscale particles, thereby equalizing mobility across the inhomogeneous metaphase cytoplasm.

KW - cell division

KW - cytoplasm

KW - diffusion

KW - macromolecular crowding

KW - metaphase

KW - microtubules

KW - mitotic spindle

KW - nanoparticles

UR - https://www.scopus.com/pages/publications/85090226537

U2 - 10.1016/j.devcel.2020.07.020

DO - 10.1016/j.devcel.2020.07.020

M3 - Article

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AN - SCOPUS:85090226537

SN - 1534-5807

VL - 54

SP - 574-582.e4

JO - Developmental Cell

JF - Developmental Cell

IS - 5

ER -

Microtubules Enhance Mesoscale Effective Diffusivity in the Crowded Metaphase Cytoplasm

Abstract

Keywords

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