MiR-15a inhibits cell proliferation and epithelial to mesenchymal transition in pancreatic ductal adenocarcinoma by down-regulating Bmi-1 expression

Shixiang Guo; Xuejun Xu; Yichen Tang; Chaobin Zhang; Jian Li; Yongsheng Ouyang; Jingfang Ju; Ping Bie; Huaizhi Wang

doi:10.1016/j.canlet.2013.10.009

MiR-15a inhibits cell proliferation and epithelial to mesenchymal transition in pancreatic ductal adenocarcinoma by down-regulating Bmi-1 expression

Shixiang Guo
, Xuejun Xu
, Yichen Tang
, Chaobin Zhang
, Jian Li
, Yongsheng Ouyang
, Jingfang Ju
, Ping Bie
, Huaizhi Wang

Pathology

Army Medical University

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Purposes: To investigate whether miR-15a inhibits cell proliferation and epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) via the down-regulation of B cell-specific moloney murine leukemia virus insertion site 1 (Bmi-1) expression. Methods and Results: miR-15a and Bmi-1 expressions in normal pancreatic tissue and PDAC tissue were measured. The relationship between miR-15a and Bmi-1 expression was analyzed. We found that miR-15a suppressed the expression of Bmi-1 and PDAC cell proliferation; E-cadherin expression was visibly up-regulated after silencing Bmi-1 by transfecting miR-15a into PDAC cell line. Conclusion: miR-15a inhibits cell proliferation and EMT in PDAC via the down-regulation of Bmi-1 expression.

Original language	English
Pages (from-to)	40-46
Number of pages	7
Journal	Cancer Letters
Volume	344
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2013.10.009
State	Published - Mar 1 2014

Keywords

Bmi-1
EMT
MiR-15a
Pancreatic ductal adenocarcinoma
Proliferation

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10.1016/j.canlet.2013.10.009

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title = "MiR-15a inhibits cell proliferation and epithelial to mesenchymal transition in pancreatic ductal adenocarcinoma by down-regulating Bmi-1 expression",

abstract = "Purposes: To investigate whether miR-15a inhibits cell proliferation and epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) via the down-regulation of B cell-specific moloney murine leukemia virus insertion site 1 (Bmi-1) expression. Methods and Results: miR-15a and Bmi-1 expressions in normal pancreatic tissue and PDAC tissue were measured. The relationship between miR-15a and Bmi-1 expression was analyzed. We found that miR-15a suppressed the expression of Bmi-1 and PDAC cell proliferation; E-cadherin expression was visibly up-regulated after silencing Bmi-1 by transfecting miR-15a into PDAC cell line. Conclusion: miR-15a inhibits cell proliferation and EMT in PDAC via the down-regulation of Bmi-1 expression.",

keywords = "Bmi-1, EMT, MiR-15a, Pancreatic ductal adenocarcinoma, Proliferation",

author = "Shixiang Guo and Xuejun Xu and Yichen Tang and Chaobin Zhang and Jian Li and Yongsheng Ouyang and Jingfang Ju and Ping Bie and Huaizhi Wang",

year = "2014",

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doi = "10.1016/j.canlet.2013.10.009",

language = "English",

volume = "344",

pages = "40--46",

journal = "Cancer Letters",

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TY - JOUR

T1 - MiR-15a inhibits cell proliferation and epithelial to mesenchymal transition in pancreatic ductal adenocarcinoma by down-regulating Bmi-1 expression

AU - Guo, Shixiang

AU - Xu, Xuejun

AU - Tang, Yichen

AU - Zhang, Chaobin

AU - Li, Jian

AU - Ouyang, Yongsheng

AU - Ju, Jingfang

AU - Bie, Ping

AU - Wang, Huaizhi

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Purposes: To investigate whether miR-15a inhibits cell proliferation and epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) via the down-regulation of B cell-specific moloney murine leukemia virus insertion site 1 (Bmi-1) expression. Methods and Results: miR-15a and Bmi-1 expressions in normal pancreatic tissue and PDAC tissue were measured. The relationship between miR-15a and Bmi-1 expression was analyzed. We found that miR-15a suppressed the expression of Bmi-1 and PDAC cell proliferation; E-cadherin expression was visibly up-regulated after silencing Bmi-1 by transfecting miR-15a into PDAC cell line. Conclusion: miR-15a inhibits cell proliferation and EMT in PDAC via the down-regulation of Bmi-1 expression.

AB - Purposes: To investigate whether miR-15a inhibits cell proliferation and epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) via the down-regulation of B cell-specific moloney murine leukemia virus insertion site 1 (Bmi-1) expression. Methods and Results: miR-15a and Bmi-1 expressions in normal pancreatic tissue and PDAC tissue were measured. The relationship between miR-15a and Bmi-1 expression was analyzed. We found that miR-15a suppressed the expression of Bmi-1 and PDAC cell proliferation; E-cadherin expression was visibly up-regulated after silencing Bmi-1 by transfecting miR-15a into PDAC cell line. Conclusion: miR-15a inhibits cell proliferation and EMT in PDAC via the down-regulation of Bmi-1 expression.

KW - Bmi-1

KW - EMT

KW - MiR-15a

KW - Pancreatic ductal adenocarcinoma

KW - Proliferation

UR - https://www.scopus.com/pages/publications/84893694761

U2 - 10.1016/j.canlet.2013.10.009

DO - 10.1016/j.canlet.2013.10.009

M3 - Article

C2 - 24252251

AN - SCOPUS:84893694761

SN - 0304-3835

VL - 344

SP - 40

EP - 46

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

MiR-15a inhibits cell proliferation and epithelial to mesenchymal transition in pancreatic ductal adenocarcinoma by down-regulating Bmi-1 expression

Abstract

Keywords

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