Modeling the dynamics of DNA electrophoresis on a flat surface

Haobin Luo; Dilip Gersappe

doi:10.1002/1522-2683(200208)23:16<2690::AID-ELPS2690>3.0.CO;2-R

Modeling the dynamics of DNA electrophoresis on a flat surface

Haobin Luo
, Dilip Gersappe

Materials Science and Engineering

Stony Brook University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We use molecular dynamics simulations to study the mechanism by which a flat, homogeneous surface can serve as an electrophoretic separation medium for DNA. We find that the mobility of DNA on the surface is a function of the conformation of the adsorbed DNA molecule, and that this mobility is controlled by the attraction between the DNA and the surface. Our results will provide guidelines for the fabrication of surfaces that can be used to separate DNA in a wide size range.

Original language	English
Pages (from-to)	2690-2696
Number of pages	7
Journal	Electrophoresis
Volume	23
Issue number	16
DOIs	https://doi.org/10.1002/1522-2683(200208)23:16<2690::AID-ELPS2690>3.0.CO;2-R
State	Published - Aug 2002

Keywords

Molecular dynamics
Simulation
Surface attraction

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10.1002/1522-2683(200208)23:16<2690::AID-ELPS2690>3.0.CO;2-R

Cite this

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AU - Gersappe, Dilip

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AB - We use molecular dynamics simulations to study the mechanism by which a flat, homogeneous surface can serve as an electrophoretic separation medium for DNA. We find that the mobility of DNA on the surface is a function of the conformation of the adsorbed DNA molecule, and that this mobility is controlled by the attraction between the DNA and the surface. Our results will provide guidelines for the fabrication of surfaces that can be used to separate DNA in a wide size range.

KW - Molecular dynamics

KW - Simulation

KW - Surface attraction

UR - https://www.scopus.com/pages/publications/0036674093

U2 - 10.1002/1522-2683(200208)23:16<2690::AID-ELPS2690>3.0.CO;2-R

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Modeling the dynamics of DNA electrophoresis on a flat surface

Abstract

Keywords

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