Modular Enzyme- and Light-Based Activation of Cyclopropene–Tetrazine Ligation

Ting Jiang; Pratik Kumar; Wei Huang; Wei Siang Kao; Adrian O. Thompson; Frank M. Camarda; Scott T. Laughlin

doi:10.1002/cbic.201900137

Modular Enzyme- and Light-Based Activation of Cyclopropene–Tetrazine Ligation

Ting Jiang
, Pratik Kumar
, Wei Huang
, Wei Siang Kao
, Adrian O. Thompson
, Frank M. Camarda
, Scott T. Laughlin

Chemistry

Stony Brook University

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We describe a modular activation strategy for cyclopropene–tetrazine ligation. This activation strategy uses chemically diverse enzyme- or photolabile protecting groups as cyclopropene reactivity cages. The linkages between the caging groups and cyclopropene are through carbamates, thus permitting the application of diverse cages to allow bioorthogonal reactivity by administering enzymes or light.

Original language	English
Pages (from-to)	2222-2226
Number of pages	5
Journal	ChemBioChem
Volume	20
Issue number	17
DOIs	https://doi.org/10.1002/cbic.201900137
State	Published - Sep 2 2019

Keywords

bioorthogonal chemistry
cyclopropene
protecting groups
reductases
tetrazines

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10.1002/cbic.201900137

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abstract = "We describe a modular activation strategy for cyclopropene–tetrazine ligation. This activation strategy uses chemically diverse enzyme- or photolabile protecting groups as cyclopropene reactivity cages. The linkages between the caging groups and cyclopropene are through carbamates, thus permitting the application of diverse cages to allow bioorthogonal reactivity by administering enzymes or light.",

keywords = "bioorthogonal chemistry, cyclopropene, protecting groups, reductases, tetrazines",

author = "Ting Jiang and Pratik Kumar and Wei Huang and Kao, \{Wei Siang\} and Thompson, \{Adrian O.\} and Camarda, \{Frank M.\} and Laughlin, \{Scott T.\}",

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T1 - Modular Enzyme- and Light-Based Activation of Cyclopropene–Tetrazine Ligation

AU - Jiang, Ting

AU - Kumar, Pratik

AU - Huang, Wei

AU - Kao, Wei Siang

AU - Thompson, Adrian O.

AU - Camarda, Frank M.

AU - Laughlin, Scott T.

PY - 2019/9/2

Y1 - 2019/9/2

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AB - We describe a modular activation strategy for cyclopropene–tetrazine ligation. This activation strategy uses chemically diverse enzyme- or photolabile protecting groups as cyclopropene reactivity cages. The linkages between the caging groups and cyclopropene are through carbamates, thus permitting the application of diverse cages to allow bioorthogonal reactivity by administering enzymes or light.

KW - bioorthogonal chemistry

KW - cyclopropene

KW - protecting groups

KW - reductases

KW - tetrazines

UR - https://www.scopus.com/pages/publications/85065514394

U2 - 10.1002/cbic.201900137

DO - 10.1002/cbic.201900137

M3 - Article

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AN - SCOPUS:85065514394

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VL - 20

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EP - 2226

JO - ChemBioChem

JF - ChemBioChem

IS - 17

ER -

Modular Enzyme- and Light-Based Activation of Cyclopropene–Tetrazine Ligation

Abstract

Keywords

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