Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells

A. Ciccodicola; R. Dono; S. Obici; A. Simeone; M. Zollo; M. Graziella Persico

doi:10.1002/j.1460-2075.1989.tb03605.x

Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells

A. Ciccodicola
, R. Dono
, S. Obici
, A. Simeone
, M. Zollo
, M. Graziella Persico

Endocrinology and Metabolism

National Research Council of Italy

Research output: Contribution to journal › Article › peer-review

232 Scopus citations

Abstract

A novel human gene, encoding a 188 amino acid polypeptide that contains a region similar to that of the epidermal growth factor, has been isolated. The gene, expressed in undifferentiated human and mouse teratocarcinoma cells, is shut off after inducing the cells to differentiate by treatment with retinoic acid. Introduction of the cDNA under the control of a viral LTR induces transformation of NIH3T3 cells.

Original language	English
Pages (from-to)	1987-1991
Number of pages	5
Journal	EMBO Journal
Volume	8
Issue number	7
DOIs	https://doi.org/10.1002/j.1460-2075.1989.tb03605.x
State	Published - 1989

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10.1002/j.1460-2075.1989.tb03605.x

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title = "Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells",

abstract = "A novel human gene, encoding a 188 amino acid polypeptide that contains a region similar to that of the epidermal growth factor, has been isolated. The gene, expressed in undifferentiated human and mouse teratocarcinoma cells, is shut off after inducing the cells to differentiate by treatment with retinoic acid. Introduction of the cDNA under the control of a viral LTR induces transformation of NIH3T3 cells.",

author = "A. Ciccodicola and R. Dono and S. Obici and A. Simeone and M. Zollo and \{Graziella Persico\}, M.",

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T1 - Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells

AU - Ciccodicola, A.

AU - Dono, R.

AU - Obici, S.

AU - Simeone, A.

AU - Zollo, M.

AU - Graziella Persico, M.

PY - 1989

Y1 - 1989

N2 - A novel human gene, encoding a 188 amino acid polypeptide that contains a region similar to that of the epidermal growth factor, has been isolated. The gene, expressed in undifferentiated human and mouse teratocarcinoma cells, is shut off after inducing the cells to differentiate by treatment with retinoic acid. Introduction of the cDNA under the control of a viral LTR induces transformation of NIH3T3 cells.

AB - A novel human gene, encoding a 188 amino acid polypeptide that contains a region similar to that of the epidermal growth factor, has been isolated. The gene, expressed in undifferentiated human and mouse teratocarcinoma cells, is shut off after inducing the cells to differentiate by treatment with retinoic acid. Introduction of the cDNA under the control of a viral LTR induces transformation of NIH3T3 cells.

UR - https://www.scopus.com/pages/publications/0024426078

U2 - 10.1002/j.1460-2075.1989.tb03605.x

DO - 10.1002/j.1460-2075.1989.tb03605.x

M3 - Article

C2 - 2792079

AN - SCOPUS:0024426078

SN - 0261-4189

VL - 8

SP - 1987

EP - 1991

JO - EMBO Journal

JF - EMBO Journal

IS - 7

ER -

Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells

Abstract

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