Morphology and morphogenesis of severe acute respiratory syndrome (SARS)-associated virus

Qin Fen Zhang; Jin Ming Cui; Xiao Jun Huang; Wei Lin; Dong Yan Tan; Jie Wei Xu; Yi Feng Yang; Jing Qiang Zhang; Xin Zhang; Hui Li; Huan Ying Zheng; Qiu Xia Chen; Xin Ge Yan; Kui Zheng; Zhuo Yue Wan; Jie Cheng Huang

Morphology and morphogenesis of severe acute respiratory syndrome (SARS)-associated virus

Qin Fen Zhang
, Jin Ming Cui
, Xiao Jun Huang
, Wei Lin
, Dong Yan Tan
, Jie Wei Xu
, Yi Feng Yang
, Jing Qiang Zhang
, Xin Zhang
, Hui Li
, Huan Ying Zheng
, Qiu Xia Chen
, Xin Ge Yan
, Kui Zheng
, Zhuo Yue Wan
, Jie Cheng Huang

Pharmacological Sciences

Sun Yat-Sen University
Guangdong Center for Disease Control and Prevention

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

After infecting the Vero E6 cells by nasal/throat swabs collected from SARS patients, we studied the SARS-associated virus by electron microscopy and molecular biological technique. The results show that the diameter of newly isolated virus is about 50nm without envelope or 100 nm with envelope. The virus was proved to be a new coronavirus by RT-PCR and it responded positively to convalescent-phase serum specimen from SARS patients, which is the evidence that this new virus is etiologically linked to the outbreak of SARS. The morphogenesis and distribution of the virus are also discussed in this article.

Original language	English
Pages (from-to)	587-591
Number of pages	5
Journal	Acta Biochimica et Biophysica Sinica
Volume	35
Issue number	6
State	Published - 2003

Keywords

Coronavirus
Electron microscopy
Severe acute respiratory syndrome (SARS)

Cite this

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title = "Morphology and morphogenesis of severe acute respiratory syndrome (SARS)-associated virus",

abstract = "After infecting the Vero E6 cells by nasal/throat swabs collected from SARS patients, we studied the SARS-associated virus by electron microscopy and molecular biological technique. The results show that the diameter of newly isolated virus is about 50nm without envelope or 100 nm with envelope. The virus was proved to be a new coronavirus by RT-PCR and it responded positively to convalescent-phase serum specimen from SARS patients, which is the evidence that this new virus is etiologically linked to the outbreak of SARS. The morphogenesis and distribution of the virus are also discussed in this article.",

keywords = "Coronavirus, Electron microscopy, Severe acute respiratory syndrome (SARS)",

author = "Zhang, \{Qin Fen\} and Cui, \{Jin Ming\} and Huang, \{Xiao Jun\} and Wei Lin and Tan, \{Dong Yan\} and Xu, \{Jie Wei\} and Yang, \{Yi Feng\} and Zhang, \{Jing Qiang\} and Xin Zhang and Hui Li and Zheng, \{Huan Ying\} and Chen, \{Qiu Xia\} and Yan, \{Xin Ge\} and Kui Zheng and Wan, \{Zhuo Yue\} and Huang, \{Jie Cheng\}",

year = "2003",

language = "English",

volume = "35",

pages = "587--591",

journal = "Acta Biochimica et Biophysica Sinica",

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TY - JOUR

T1 - Morphology and morphogenesis of severe acute respiratory syndrome (SARS)-associated virus

AU - Zhang, Qin Fen

AU - Cui, Jin Ming

AU - Huang, Xiao Jun

AU - Lin, Wei

AU - Tan, Dong Yan

AU - Xu, Jie Wei

AU - Yang, Yi Feng

AU - Zhang, Jing Qiang

AU - Zhang, Xin

AU - Li, Hui

AU - Zheng, Huan Ying

AU - Chen, Qiu Xia

AU - Yan, Xin Ge

AU - Zheng, Kui

AU - Wan, Zhuo Yue

AU - Huang, Jie Cheng

PY - 2003

Y1 - 2003

N2 - After infecting the Vero E6 cells by nasal/throat swabs collected from SARS patients, we studied the SARS-associated virus by electron microscopy and molecular biological technique. The results show that the diameter of newly isolated virus is about 50nm without envelope or 100 nm with envelope. The virus was proved to be a new coronavirus by RT-PCR and it responded positively to convalescent-phase serum specimen from SARS patients, which is the evidence that this new virus is etiologically linked to the outbreak of SARS. The morphogenesis and distribution of the virus are also discussed in this article.

AB - After infecting the Vero E6 cells by nasal/throat swabs collected from SARS patients, we studied the SARS-associated virus by electron microscopy and molecular biological technique. The results show that the diameter of newly isolated virus is about 50nm without envelope or 100 nm with envelope. The virus was proved to be a new coronavirus by RT-PCR and it responded positively to convalescent-phase serum specimen from SARS patients, which is the evidence that this new virus is etiologically linked to the outbreak of SARS. The morphogenesis and distribution of the virus are also discussed in this article.

KW - Coronavirus

KW - Electron microscopy

KW - Severe acute respiratory syndrome (SARS)

UR - https://www.scopus.com/pages/publications/0042140675

M3 - Article

C2 - 12796822

AN - SCOPUS:0042140675

SN - 0582-9879

VL - 35

SP - 587

EP - 591

JO - Acta Biochimica et Biophysica Sinica

JF - Acta Biochimica et Biophysica Sinica

IS - 6

ER -

Morphology and morphogenesis of severe acute respiratory syndrome (SARS)-associated virus

Abstract

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