Multiple ADH genes are associated with upper aerodigestive cancers

Mia Hashibe; James D. McKay; Maria Paula Curado; Jose Carlos Oliveira; Sergio Koifman; Rosalina Koifman; David Zaridze; Oxana Shangina; Victor Wünsch-Filho; Jose Eluf-Neto; Jose Eduardo Levi; Elena Matos; Pagona Lagiou; Areti Lagiou; Simone Benhamou; Christine Bouchardy; Neonilia Szeszenia-Dabrowska; Ana Menezes; Marinel Mór Dall'Agnol; Franco Merletti; Lorenzo Richiardi; Leticia Fernandez; Juan Lence; Renato Talamini; Luigi Barzan; Dana Mates; Ioan Nicolae Mates; Kristina Kjaerheim; Gary J. MacFarlane; Tatiana V. MacFarlane; Lorenzo Simonato; Cristina Canova; Ivana Holcátová; Antonio Agudo; Xavier Castellsagué; Ray Lowry; Vladimir Janout; Helena Kollarova; David I. Conway; Patricia A. McKinney; Ariana Znaor; Eleonora Fabianova; Vladimir Bencko; Jolanta Lissowska; Amelie Chabrier; Rayjean J. Hung; Valerie Gaborieau; Paolo Boffetta; Paul Brennan

doi:10.1038/ng.151

Multiple ADH genes are associated with upper aerodigestive cancers

Mia Hashibe
, James D. McKay
, Maria Paula Curado
, Jose Carlos Oliveira
, Sergio Koifman
, Rosalina Koifman
, David Zaridze
, Oxana Shangina
, Victor Wünsch-Filho
, Jose Eluf-Neto
, Jose Eduardo Levi
, Elena Matos
, Pagona Lagiou
, Areti Lagiou
, Simone Benhamou
, Christine Bouchardy
, Neonilia Szeszenia-Dabrowska
, Ana Menezes
, Marinel Mór Dall'Agnol
, Franco Merletti

Lorenzo Richiardi, Leticia Fernandez, Juan Lence, Renato Talamini, Luigi Barzan, Dana Mates, Ioan Nicolae Mates, Kristina Kjaerheim, Gary J. MacFarlane, Tatiana V. MacFarlane, Lorenzo Simonato, Cristina Canova, Ivana Holcátová, Antonio Agudo, Xavier Castellsagué, Ray Lowry, Vladimir Janout, Helena Kollarova, David I. Conway, Patricia A. McKinney, Ariana Znaor, Eleonora Fabianova, Vladimir Bencko, Jolanta Lissowska, Amelie Chabrier, Rayjean J. Hung, Valerie Gaborieau, Paolo Boffetta, Paul Brennan

Family , Population and Preventative Medicine

International Agency for Research on Cancer
Hospital Araujo Jorge
Populational Cancer Register of Goiania
Escola Nacional de Suade Publica
Blokhin Cancer Research Center
Universidade de São Paulo
Universidad de Buenos Aires
National and Kapodistrian University of Athens
Institut National de la Santé et de la Recherche Médicale U794
University of Geneva
Nofer Institute of Occupational Medicine
University of Turin
National School of Public Health
IRCCS Centro di Riferimento Oncologico - Aviano PN
General Hospital of Pordenone
National Institute of Public Health
Carol Davila University of Medicine and Pharmacy
Cancer Registry of Norway Institute of Population-Based Cancer Research
University of Aberdeen
University of Padua
Charles University
Institute Catala Oncologia
Newcastle University
Palacký University Olomouc
University of Glasgow
University of Leeds
NHS National Services Scotland
Croatian National Cancer Registry
Specialized State Health Institute
Maria Sklodowska-Curie Institute of Oncology
University of California at Berkeley

Research output: Contribution to journal › Article › peer-review

169 Scopus citations

Abstract

Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10^-10 and 10 ^-9, respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.

Original language	English
Pages (from-to)	707-709
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	6
DOIs	https://doi.org/10.1038/ng.151
State	Published - Jun 2008

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Hashibe, M., McKay, J. D., Curado, M. P., Oliveira, J. C., Koifman, S., Koifman, R., Zaridze, D., Shangina, O., Wünsch-Filho, V., Eluf-Neto, J., Levi, J. E., Matos, E., Lagiou, P., Lagiou, A., Benhamou, S., Bouchardy, C., Szeszenia-Dabrowska, N., Menezes, A., Dall'Agnol, M. M., ... Brennan, P. (2008). Multiple ADH genes are associated with upper aerodigestive cancers. Nature Genetics, 40(6), 707-709. https://doi.org/10.1038/ng.151

@article{3f6a21a65ea64cb3bc7d94c0886378ea,

title = "Multiple ADH genes are associated with upper aerodigestive cancers",

abstract = "Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10-10 and 10 -9, respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.",

author = "Mia Hashibe and McKay, \{James D.\} and Curado, \{Maria Paula\} and Oliveira, \{Jose Carlos\} and Sergio Koifman and Rosalina Koifman and David Zaridze and Oxana Shangina and Victor W{\"u}nsch-Filho and Jose Eluf-Neto and Levi, \{Jose Eduardo\} and Elena Matos and Pagona Lagiou and Areti Lagiou and Simone Benhamou and Christine Bouchardy and Neonilia Szeszenia-Dabrowska and Ana Menezes and Dall'Agnol, \{Marinel M{\'o}r\} and Franco Merletti and Lorenzo Richiardi and Leticia Fernandez and Juan Lence and Renato Talamini and Luigi Barzan and Dana Mates and Mates, \{Ioan Nicolae\} and Kristina Kjaerheim and MacFarlane, \{Gary J.\} and MacFarlane, \{Tatiana V.\} and Lorenzo Simonato and Cristina Canova and Ivana Holc{\'a}tov{\'a} and Antonio Agudo and Xavier Castellsagu{\'e} and Ray Lowry and Vladimir Janout and Helena Kollarova and Conway, \{David I.\} and McKinney, \{Patricia A.\} and Ariana Znaor and Eleonora Fabianova and Vladimir Bencko and Jolanta Lissowska and Amelie Chabrier and Hung, \{Rayjean J.\} and Valerie Gaborieau and Paolo Boffetta and Paul Brennan",

year = "2008",

month = jun,

doi = "10.1038/ng.151",

language = "English",

volume = "40",

pages = "707--709",

journal = "Nature Genetics",

issn = "1061-4036",

number = "6",

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Hashibe, M, McKay, JD, Curado, MP, Oliveira, JC, Koifman, S, Koifman, R, Zaridze, D, Shangina, O, Wünsch-Filho, V, Eluf-Neto, J, Levi, JE, Matos, E, Lagiou, P, Lagiou, A, Benhamou, S, Bouchardy, C, Szeszenia-Dabrowska, N, Menezes, A, Dall'Agnol, MM, Merletti, F, Richiardi, L, Fernandez, L, Lence, J, Talamini, R, Barzan, L, Mates, D, Mates, IN, Kjaerheim, K, MacFarlane, GJ, MacFarlane, TV, Simonato, L, Canova, C, Holcátová, I, Agudo, A, Castellsagué, X, Lowry, R, Janout, V, Kollarova, H, Conway, DI, McKinney, PA, Znaor, A, Fabianova, E, Bencko, V, Lissowska, J, Chabrier, A, Hung, RJ, Gaborieau, V, Boffetta, P & Brennan, P 2008, 'Multiple ADH genes are associated with upper aerodigestive cancers', Nature Genetics, vol. 40, no. 6, pp. 707-709. https://doi.org/10.1038/ng.151

TY - JOUR

T1 - Multiple ADH genes are associated with upper aerodigestive cancers

AU - Hashibe, Mia

AU - McKay, James D.

AU - Curado, Maria Paula

AU - Oliveira, Jose Carlos

AU - Koifman, Sergio

AU - Koifman, Rosalina

AU - Zaridze, David

AU - Shangina, Oxana

AU - Wünsch-Filho, Victor

AU - Eluf-Neto, Jose

AU - Levi, Jose Eduardo

AU - Matos, Elena

AU - Lagiou, Pagona

AU - Lagiou, Areti

AU - Benhamou, Simone

AU - Bouchardy, Christine

AU - Szeszenia-Dabrowska, Neonilia

AU - Menezes, Ana

AU - Dall'Agnol, Marinel Mór

AU - Merletti, Franco

AU - Richiardi, Lorenzo

AU - Fernandez, Leticia

AU - Lence, Juan

AU - Talamini, Renato

AU - Barzan, Luigi

AU - Mates, Dana

AU - Mates, Ioan Nicolae

AU - Kjaerheim, Kristina

AU - MacFarlane, Gary J.

AU - MacFarlane, Tatiana V.

AU - Simonato, Lorenzo

AU - Canova, Cristina

AU - Holcátová, Ivana

AU - Agudo, Antonio

AU - Castellsagué, Xavier

AU - Lowry, Ray

AU - Janout, Vladimir

AU - Kollarova, Helena

AU - Conway, David I.

AU - McKinney, Patricia A.

AU - Znaor, Ariana

AU - Fabianova, Eleonora

AU - Bencko, Vladimir

AU - Lissowska, Jolanta

AU - Chabrier, Amelie

AU - Hung, Rayjean J.

AU - Gaborieau, Valerie

AU - Boffetta, Paolo

AU - Brennan, Paul

PY - 2008/6

Y1 - 2008/6

N2 - Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10-10 and 10 -9, respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.

AB - Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10-10 and 10 -9, respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.

UR - https://www.scopus.com/pages/publications/44349179705

U2 - 10.1038/ng.151

DO - 10.1038/ng.151

M3 - Article

C2 - 18500343

AN - SCOPUS:44349179705

SN - 1061-4036

VL - 40

SP - 707

EP - 709

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

Multiple ADH genes are associated with upper aerodigestive cancers

Abstract

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