Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

B. Hille; D. J. Beech; L. Bernheim; A. Mathie; M. S. Shapiro; L. P. Wollmuth

doi:10.1016/0024-3205(95)00038-8

Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

B. Hille
, D. J. Beech
, L. Bernheim
, A. Mathie
, M. S. Shapiro
, L. P. Wollmuth

Neurobiology and Behavior

University of Washington
University of Leeds
University of Geneva
Royal Free London NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Muscarinic receptors depress Ca²⁺ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.

Original language	English
Pages (from-to)	989-992
Number of pages	4
Journal	Life Sciences
Volume	56
Issue number	11-12
DOIs	https://doi.org/10.1016/0024-3205(95)00038-8
State	Published - Feb 10 1995

Keywords

himbacine
muscarinic receptor
pertussis toxin
pirenzepine
sympathetic ganglion

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10.1016/0024-3205(95)00038-8

Cite this

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abstract = "Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.",

keywords = "himbacine, muscarinic receptor, pertussis toxin, pirenzepine, sympathetic ganglion",

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T1 - Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

AU - Hille, B.

AU - Beech, D. J.

AU - Bernheim, L.

AU - Mathie, A.

AU - Shapiro, M. S.

AU - Wollmuth, L. P.

PY - 1995/2/10

Y1 - 1995/2/10

N2 - Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.

AB - Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.

KW - himbacine

KW - muscarinic receptor

KW - pertussis toxin

KW - pirenzepine

KW - sympathetic ganglion

UR - https://www.scopus.com/pages/publications/0028941142

U2 - 10.1016/0024-3205(95)00038-8

DO - 10.1016/0024-3205(95)00038-8

M3 - Article

C2 - 10188803

AN - SCOPUS:0028941142

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SP - 989

EP - 992

JO - Life Sciences

JF - Life Sciences

IS - 11-12

ER -

Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

Abstract

Keywords

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