Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS)

Axel Petzold; Valerie Biousse; Lulu Bursztyn; Fiona Costello; Alison Crum; Kathleen Digre; Clare Fraser; J. Alex Fraser; Bradley Katz; Neringa Jurkute; Nancy Newman; Jette Lautrup-Battistini; Mitchell Lawlor; Petra Liskova; Birgit Lorenz; Lasse Malmqvist; Jason Peragallo; Patrick Sibony; Prem Subramanian; Robert Rejdak; Katarzyna Nowomiejska; Valerie Touitou; Judith Warner; Marianne Wegener; Sui Wong; Patrick Yu-Wai-Man; Steffen Hamann

doi:10.1080/01658107.2020.1760891

Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS)

Axel Petzold
, Valerie Biousse
, Lulu Bursztyn
, Fiona Costello
, Alison Crum
, Kathleen Digre
, Clare Fraser
, J. Alex Fraser
, Bradley Katz
, Neringa Jurkute
, Nancy Newman
, Jette Lautrup-Battistini
, Mitchell Lawlor
, Petra Liskova
, Birgit Lorenz
, Lasse Malmqvist
, Jason Peragallo
, Patrick Sibony
, Prem Subramanian
, Robert Rejdak

Katarzyna Nowomiejska, Valerie Touitou, Judith Warner, Marianne Wegener, Sui Wong, Patrick Yu-Wai-Man, Steffen Hamann

Ophthalmology

Moorfields Eye Hospital NHS Foundation Trust
VU University Medical Center
Emory University
Western University
University of Calgary
Utah System of Higher Education
University of Utah
The University of Sydney
University College London
University of Copenhagen
Charles University
Justus Liebig University Giessen
University of Colorado Anschutz Medical Campus
Medical University of Lublin
Sorbonne Université
University of Cambridge

Research output: Contribution to journal › Letter › peer-review

32 Scopus citations

Abstract

Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a new retinal optical coherence tomography (OCT) finding. The Optic Disc Drusen Studies Consortium had made recommendations to distinguish PHOMS from true optic disc drusen (ODD) in 2018. While publications on PHOMS have increased since then, the accuracy of the definition of PHOMS and reliability of detection is unknown. In this multi-rater study, we demonstrate that the 2018 definition of PHOMS resulted in a poor multi-rater kappa of 0.356. We performed a Delphi consensus process to develop a consistent and refined definition of PHOMS with clear principles around the nature of PHOMS and how they differ from normal anatomy. Fifty explanatory teaching slides, provided as supplementary material, allowed our expert group of raters to achieve a good level of agreement (kappa 0.701, 50 OCT scans, 21 raters). We recommend adopting the refined definition for PHOMS.

Original language	English
Pages (from-to)	413-414
Number of pages	2
Journal	Neuro-Ophthalmology
DOIs	https://doi.org/10.1080/01658107.2020.1760891
State	Published - 2020

Keywords

OCT
ODD
PHOMS

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10.1080/01658107.2020.1760891

Cite this

Petzold, A., Biousse, V., Bursztyn, L., Costello, F., Crum, A., Digre, K., Fraser, C., Fraser, J. A., Katz, B., Jurkute, N., Newman, N., Lautrup-Battistini, J., Lawlor, M., Liskova, P., Lorenz, B., Malmqvist, L., Peragallo, J., Sibony, P., Subramanian, P., ... Hamann, S. (2020). Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS). Neuro-Ophthalmology, 413-414. https://doi.org/10.1080/01658107.2020.1760891

@article{faf4e39f7d07455588e3c6f1ed60a576,

title = "Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS)",

abstract = "Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a new retinal optical coherence tomography (OCT) finding. The Optic Disc Drusen Studies Consortium had made recommendations to distinguish PHOMS from true optic disc drusen (ODD) in 2018. While publications on PHOMS have increased since then, the accuracy of the definition of PHOMS and reliability of detection is unknown. In this multi-rater study, we demonstrate that the 2018 definition of PHOMS resulted in a poor multi-rater kappa of 0.356. We performed a Delphi consensus process to develop a consistent and refined definition of PHOMS with clear principles around the nature of PHOMS and how they differ from normal anatomy. Fifty explanatory teaching slides, provided as supplementary material, allowed our expert group of raters to achieve a good level of agreement (kappa 0.701, 50 OCT scans, 21 raters). We recommend adopting the refined definition for PHOMS.",

keywords = "OCT, ODD, PHOMS",

author = "Axel Petzold and Valerie Biousse and Lulu Bursztyn and Fiona Costello and Alison Crum and Kathleen Digre and Clare Fraser and Fraser, \{J. Alex\} and Bradley Katz and Neringa Jurkute and Nancy Newman and Jette Lautrup-Battistini and Mitchell Lawlor and Petra Liskova and Birgit Lorenz and Lasse Malmqvist and Jason Peragallo and Patrick Sibony and Prem Subramanian and Robert Rejdak and Katarzyna Nowomiejska and Valerie Touitou and Judith Warner and Marianne Wegener and Sui Wong and Patrick Yu-Wai-Man and Steffen Hamann",

note = "Publisher Copyright: {\textcopyright} 2020, {\textcopyright} 2020 Taylor \& Francis Group, LLC.",

year = "2020",

doi = "10.1080/01658107.2020.1760891",

language = "English",

pages = "413--414",

journal = "Neuro-Ophthalmology",

issn = "0165-8107",

}

Petzold, A, Biousse, V, Bursztyn, L, Costello, F, Crum, A, Digre, K, Fraser, C, Fraser, JA, Katz, B, Jurkute, N, Newman, N, Lautrup-Battistini, J, Lawlor, M, Liskova, P, Lorenz, B, Malmqvist, L, Peragallo, J, Sibony, P, Subramanian, P, Rejdak, R, Nowomiejska, K, Touitou, V, Warner, J, Wegener, M, Wong, S, Yu-Wai-Man, P & Hamann, S 2020, 'Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS)', Neuro-Ophthalmology, pp. 413-414. https://doi.org/10.1080/01658107.2020.1760891

TY - JOUR

T1 - Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS)

AU - Petzold, Axel

AU - Biousse, Valerie

AU - Bursztyn, Lulu

AU - Costello, Fiona

AU - Crum, Alison

AU - Digre, Kathleen

AU - Fraser, Clare

AU - Fraser, J. Alex

AU - Katz, Bradley

AU - Jurkute, Neringa

AU - Newman, Nancy

AU - Lautrup-Battistini, Jette

AU - Lawlor, Mitchell

AU - Liskova, Petra

AU - Lorenz, Birgit

AU - Malmqvist, Lasse

AU - Peragallo, Jason

AU - Sibony, Patrick

AU - Subramanian, Prem

AU - Rejdak, Robert

AU - Nowomiejska, Katarzyna

AU - Touitou, Valerie

AU - Warner, Judith

AU - Wegener, Marianne

AU - Wong, Sui

AU - Yu-Wai-Man, Patrick

AU - Hamann, Steffen

PY - 2020

Y1 - 2020

N2 - Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a new retinal optical coherence tomography (OCT) finding. The Optic Disc Drusen Studies Consortium had made recommendations to distinguish PHOMS from true optic disc drusen (ODD) in 2018. While publications on PHOMS have increased since then, the accuracy of the definition of PHOMS and reliability of detection is unknown. In this multi-rater study, we demonstrate that the 2018 definition of PHOMS resulted in a poor multi-rater kappa of 0.356. We performed a Delphi consensus process to develop a consistent and refined definition of PHOMS with clear principles around the nature of PHOMS and how they differ from normal anatomy. Fifty explanatory teaching slides, provided as supplementary material, allowed our expert group of raters to achieve a good level of agreement (kappa 0.701, 50 OCT scans, 21 raters). We recommend adopting the refined definition for PHOMS.

AB - Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a new retinal optical coherence tomography (OCT) finding. The Optic Disc Drusen Studies Consortium had made recommendations to distinguish PHOMS from true optic disc drusen (ODD) in 2018. While publications on PHOMS have increased since then, the accuracy of the definition of PHOMS and reliability of detection is unknown. In this multi-rater study, we demonstrate that the 2018 definition of PHOMS resulted in a poor multi-rater kappa of 0.356. We performed a Delphi consensus process to develop a consistent and refined definition of PHOMS with clear principles around the nature of PHOMS and how they differ from normal anatomy. Fifty explanatory teaching slides, provided as supplementary material, allowed our expert group of raters to achieve a good level of agreement (kappa 0.701, 50 OCT scans, 21 raters). We recommend adopting the refined definition for PHOMS.

KW - OCT

KW - ODD

KW - PHOMS

UR - https://www.scopus.com/pages/publications/85086173129

U2 - 10.1080/01658107.2020.1760891

DO - 10.1080/01658107.2020.1760891

M3 - Letter

AN - SCOPUS:85086173129

SN - 0165-8107

SP - 413

EP - 414

JO - Neuro-Ophthalmology

JF - Neuro-Ophthalmology

ER -

Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS)

Abstract

Keywords

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