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Multiscale analysis of cancer cell mechanics

  • Massachusetts Institute of Technology
  • Boston University

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Physiological phenomena occur in complex 3D environments. However, the mechanics of cells in 3D under relevant conditions such as flow and chemical signals are not well understood. These mechanics can have important implications in pathological events such as cancer metastasis, where cancer cells undergo transformations that enable invasive behavior across constrictive physiological barriers. In our work, we have taken an integrated computational and experimental approach to establish a multiscale understanding of the fundamental mechanical properties of cancer cells in native-like conditions.

Original languageEnglish
Title of host publicationProceedings - 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479937288
DOIs
StatePublished - Dec 2 2014
Event2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014 - Boston, United States
Duration: Apr 25 2014Apr 27 2014

Publication series

NameProceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
Volume2014-December
ISSN (Print)1071-121X
ISSN (Electronic)2160-7001

Conference

Conference2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
Country/TerritoryUnited States
CityBoston
Period04/25/1404/27/14

Keywords

  • Cancer metastasis
  • Mechanobiology
  • Microfluidics

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