Myotube assembly on nanofibrous and micropatterned polymers

Ngan F. Huang; Shyam Patel; Rahul G. Thakar; Jun Wu; Benjamin S. Hsiao; Benjamin Chu; Randall J. Lee; Song Li

doi:10.1021/nl060060o

Myotube assembly on nanofibrous and micropatterned polymers

Ngan F. Huang
, Shyam Patel
, Rahul G. Thakar
, Jun Wu
, Benjamin S. Hsiao
, Benjamin Chu
, Randall J. Lee
, Song Li

Chemistry

University of California at San Francisco
University of California at Berkeley
Stony Brook University

Research output: Contribution to journal › Article › peer-review

307 Scopus citations

Abstract

Skeletal muscle consists of parallel bundles of myotubes formed by the fusion of myoblasts. We fabricated nanofibrous and micropatterned polymers as cell culture substrates to guide the morphogenesis of muscular tissue. The nanoscale and microscale topographic features regulate cell and cytoskeleton alignment, myotube assembly, myotube striation, and myoblast proliferation. This bottom-up approach from nanoscale to tissue level demonstrates the potential of nanofibrous polymers for engineering the assembly of cell and tissue structure.

Original language	English
Pages (from-to)	537-542
Number of pages	6
Journal	Nano Letters
Volume	6
Issue number	3
DOIs	https://doi.org/10.1021/nl060060o
State	Published - Mar 2006

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abstract = "Skeletal muscle consists of parallel bundles of myotubes formed by the fusion of myoblasts. We fabricated nanofibrous and micropatterned polymers as cell culture substrates to guide the morphogenesis of muscular tissue. The nanoscale and microscale topographic features regulate cell and cytoskeleton alignment, myotube assembly, myotube striation, and myoblast proliferation. This bottom-up approach from nanoscale to tissue level demonstrates the potential of nanofibrous polymers for engineering the assembly of cell and tissue structure.",

author = "Huang, \{Ngan F.\} and Shyam Patel and Thakar, \{Rahul G.\} and Jun Wu and Hsiao, \{Benjamin S.\} and Benjamin Chu and Lee, \{Randall J.\} and Song Li",

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doi = "10.1021/nl060060o",

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AU - Huang, Ngan F.

AU - Patel, Shyam

AU - Thakar, Rahul G.

AU - Wu, Jun

AU - Hsiao, Benjamin S.

AU - Chu, Benjamin

AU - Lee, Randall J.

AU - Li, Song

PY - 2006/3

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N2 - Skeletal muscle consists of parallel bundles of myotubes formed by the fusion of myoblasts. We fabricated nanofibrous and micropatterned polymers as cell culture substrates to guide the morphogenesis of muscular tissue. The nanoscale and microscale topographic features regulate cell and cytoskeleton alignment, myotube assembly, myotube striation, and myoblast proliferation. This bottom-up approach from nanoscale to tissue level demonstrates the potential of nanofibrous polymers for engineering the assembly of cell and tissue structure.

AB - Skeletal muscle consists of parallel bundles of myotubes formed by the fusion of myoblasts. We fabricated nanofibrous and micropatterned polymers as cell culture substrates to guide the morphogenesis of muscular tissue. The nanoscale and microscale topographic features regulate cell and cytoskeleton alignment, myotube assembly, myotube striation, and myoblast proliferation. This bottom-up approach from nanoscale to tissue level demonstrates the potential of nanofibrous polymers for engineering the assembly of cell and tissue structure.

UR - https://www.scopus.com/pages/publications/33645380605

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DO - 10.1021/nl060060o

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SP - 537

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JO - Nano Letters

JF - Nano Letters

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ER -

Myotube assembly on nanofibrous and micropatterned polymers

Abstract

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