N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs

Iwao Ojima; Martine Zucco; Olivier Duclos; Scott D. Kuduk; Chung Ming Sun; Young Hoon Park

doi:10.1016/S0960-894X(01)80982-3

N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs

Iwao Ojima
, Martine Zucco
, Olivier Duclos
, Scott D. Kuduk
, Chung Ming Sun
, Young Hoon Park

Chemistry

Stony Brook University

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

(3R,4S)-3-(protected hydroxy)-4-substituted β-lactams bearing N-alkoxycarbonyl, N-arloxycarbonyl, and N-carbamoyl groups are found to be useful for the synthesis of taxotère and its analogs through coupling with baccatin III.

Original language	English
Pages (from-to)	2479-2482
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	11
DOIs	https://doi.org/10.1016/S0960-894X(01)80982-3
State	Published - Nov 1993

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title = "N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs",

abstract = "(3R,4S)-3-(protected hydroxy)-4-substituted β-lactams bearing N-alkoxycarbonyl, N-arloxycarbonyl, and N-carbamoyl groups are found to be useful for the synthesis of taxot{\`e}re and its analogs through coupling with baccatin III.",

author = "Iwao Ojima and Martine Zucco and Olivier Duclos and Kuduk, \{Scott D.\} and Sun, \{Chung Ming\} and Park, \{Young Hoon\}",

year = "1993",

month = nov,

doi = "10.1016/S0960-894X(01)80982-3",

language = "English",

volume = "3",

pages = "2479--2482",

journal = "Bioorganic and Medicinal Chemistry Letters",

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number = "11",

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T1 - N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs

AU - Ojima, Iwao

AU - Zucco, Martine

AU - Duclos, Olivier

AU - Kuduk, Scott D.

AU - Sun, Chung Ming

AU - Park, Young Hoon

PY - 1993/11

Y1 - 1993/11

N2 - (3R,4S)-3-(protected hydroxy)-4-substituted β-lactams bearing N-alkoxycarbonyl, N-arloxycarbonyl, and N-carbamoyl groups are found to be useful for the synthesis of taxotère and its analogs through coupling with baccatin III.

AB - (3R,4S)-3-(protected hydroxy)-4-substituted β-lactams bearing N-alkoxycarbonyl, N-arloxycarbonyl, and N-carbamoyl groups are found to be useful for the synthesis of taxotère and its analogs through coupling with baccatin III.

UR - https://www.scopus.com/pages/publications/0027742280

U2 - 10.1016/S0960-894X(01)80982-3

DO - 10.1016/S0960-894X(01)80982-3

M3 - Article

AN - SCOPUS:0027742280

SN - 0960-894X

VL - 3

SP - 2479

EP - 2482

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs

Abstract

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