@inproceedings{77caceca3af0496b8ebb6b5945beeab4,
title = "Nanometer resolution hard X-ray microscopy of bone and mineralized tissue",
abstract = "Full field hard x-ray microscopy has recently been developed utilizing synchrotron light, enabling absorption and phase contrast imaging with a spatial resolution of 50 - 100 nm. This technique has allowed us to image bone tissue at the nanoscale level, viewing the substructure of mineralized collagen fibers. Thin sections of tissue (5 and 50 μm thick) from the L3 vertebrae of Beagles and mineralizing MC3T3-E1 mouse osteoblasts were imaged at beamline 01B1 at the National Synchrotron Radiation Research Center (Hsinchu, Taiwan). Collagen fiber orientation was observed in the lamellar structure of an osteon. Mineralizing osteoblasts were found to produce disordered mineralized nodules with varying density and structure.",
author = "Ruppel, \{M. E.\} and Y. Meng and Y. Qin and Burr, \{D. B.\} and Allen, \{M. R.\} and Song, \{Y. F.\} and Miller, \{L. M.\}",
year = "2007",
doi = "10.1109/NEBC.2007.4413266",
language = "English",
isbn = "1424410339",
series = "Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "33--34",
booktitle = "33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC",
note = "33rd Annual Northeast Bioengineering Conference, NEBC ; Conference date: 10-03-2007 Through 11-03-2007",
}