TY - GEN
T1 - Nanoparticle-enhanced proton computed tomography
T2 - 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
AU - Schulte, Reinhard
AU - Bashkirov, Vladimir
AU - Li, Tianfang
AU - Liang, Zhengrong
AU - Sadrozinski, Hartmut F.W.
AU - Williams, David C.
PY - 2004
Y1 - 2004
N2 - Proton computed tomography (pCT) has the potential to improve the accuracy of proton treatment planning, which is currently based on x-ray computed tomography (xCT). However, at this time no method exists for pCT to selectively increase the contrast of tumor tissues with respect to normal tissues. One possibility to achieve this goal is to bind gold-nanoparticles, i.e., microscopic structures in the size range of 1 nm to several hundred nanometers, to the surface of tumor cells with cell-seeking antibodies conjugated to the surface of the nanoparticles. In order to test the suitability of this approach, we used the Monte Carlo transport code GEANT4, to provide simulated histories of 200 MeV protons going through a cylindrical water phantom with embedded inhomongenities enhanced with traces of gold. The energy loss of several million protons traversing the cylinder from 180 different angles formed the basis for reconstructing the a single proton CT image representing the relative volume electron density map of the phantom using an approximate filtered back projection algorithm. Our results demonstrate that with hundred nanoparticles of 100 nm diameter per tumor cell, it may be possible to enhance the visibility of tumors in pCT.
AB - Proton computed tomography (pCT) has the potential to improve the accuracy of proton treatment planning, which is currently based on x-ray computed tomography (xCT). However, at this time no method exists for pCT to selectively increase the contrast of tumor tissues with respect to normal tissues. One possibility to achieve this goal is to bind gold-nanoparticles, i.e., microscopic structures in the size range of 1 nm to several hundred nanometers, to the surface of tumor cells with cell-seeking antibodies conjugated to the surface of the nanoparticles. In order to test the suitability of this approach, we used the Monte Carlo transport code GEANT4, to provide simulated histories of 200 MeV protons going through a cylindrical water phantom with embedded inhomongenities enhanced with traces of gold. The energy loss of several million protons traversing the cylinder from 180 different angles formed the basis for reconstructing the a single proton CT image representing the relative volume electron density map of the phantom using an approximate filtered back projection algorithm. Our results demonstrate that with hundred nanoparticles of 100 nm diameter per tumor cell, it may be possible to enhance the visibility of tumors in pCT.
UR - https://www.scopus.com/pages/publications/17144430156
M3 - Conference contribution
AN - SCOPUS:17144430156
SN - 0780383885
SN - 9780780383883
T3 - 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
SP - 1354
EP - 1356
BT - 2004 2nd IEEE International Symposium on Biomedical Imaging
Y2 - 15 April 2004 through 18 April 2004
ER -