Neoplasms in a pediatric population: 2-[F-18]-fluoro-2-deoxy-D-glucose PET studies

Barry L. Shulkin; Deanna S. Mitchell; David R. Ungar; Devina Prakash; Mukund G. Dole; Valerie P. Castle; Ramiro J. Hernandez; Robert A. Koeppe; Raymond J. Hutchinson

doi:10.1148/radiology.194.2.7824731

Neoplasms in a pediatric population: 2-[F-18]-fluoro-2-deoxy-D-glucose PET studies

Barry L. Shulkin
, Deanna S. Mitchell
, David R. Ungar
, Devina Prakash
, Mukund G. Dole
, Valerie P. Castle
, Ramiro J. Hernandez
, Robert A. Koeppe
, Raymond J. Hutchinson

Pediatrics

University of Michigan, Ann Arbor

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

PURPOSE: To assess the uptake of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in common and uncommon tumors in children and to develop a method for performing positron emission tomography (PET) studies in children with malignant neoplasms. MATERIALS AND METHODS: Twenty-two pediatric patients with known or suspected malignancies (27 scans) underwent FDG PET. Tumor uptake of FDG was measured on PET scans. RESULTS: Tumor uptake of FDG was detected in 17 of 21 patients with malignant disease. Neuroblastomas and their metastases (including those that did not absorb metaiodobenzyl- guanidine) intensely accumulated FDG. In a patient with Ewing sarcoma, FDG PET showed two foci of metastatic disease not evident on bone scans. In two patients, PET showed that large areas of the tumor were necrotic. CONCLUSION: FDG PET is feasible, is useful in the study of tumors in children, and may provide unique, clinically important information.

Original language	English
Pages (from-to)	495-500
Number of pages	6
Journal	Radiology
Volume	194
Issue number	2
DOIs	https://doi.org/10.1148/radiology.194.2.7824731
State	Published - Feb 1995

Keywords

Emission CT
Neoplasms, in infants and children
Radionuclides

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10.1148/radiology.194.2.7824731

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@article{ac387d6994f74992b6c41d164fec2a47,

title = "Neoplasms in a pediatric population: 2-[F-18]-fluoro-2-deoxy-D-glucose PET studies",

abstract = "PURPOSE: To assess the uptake of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in common and uncommon tumors in children and to develop a method for performing positron emission tomography (PET) studies in children with malignant neoplasms. MATERIALS AND METHODS: Twenty-two pediatric patients with known or suspected malignancies (27 scans) underwent FDG PET. Tumor uptake of FDG was measured on PET scans. RESULTS: Tumor uptake of FDG was detected in 17 of 21 patients with malignant disease. Neuroblastomas and their metastases (including those that did not absorb metaiodobenzyl- guanidine) intensely accumulated FDG. In a patient with Ewing sarcoma, FDG PET showed two foci of metastatic disease not evident on bone scans. In two patients, PET showed that large areas of the tumor were necrotic. CONCLUSION: FDG PET is feasible, is useful in the study of tumors in children, and may provide unique, clinically important information.",

keywords = "Emission CT, Neoplasms, in infants and children, Radionuclides",

author = "Shulkin, \{Barry L.\} and Mitchell, \{Deanna S.\} and Ungar, \{David R.\} and Devina Prakash and Dole, \{Mukund G.\} and Castle, \{Valerie P.\} and Hernandez, \{Ramiro J.\} and Koeppe, \{Robert A.\} and Hutchinson, \{Raymond J.\}",

year = "1995",

month = feb,

doi = "10.1148/radiology.194.2.7824731",

language = "English",

volume = "194",

pages = "495--500",

journal = "Radiology",

issn = "0033-8419",

number = "2",

}

TY - JOUR

T1 - Neoplasms in a pediatric population

T2 - 2-[F-18]-fluoro-2-deoxy-D-glucose PET studies

AU - Shulkin, Barry L.

AU - Mitchell, Deanna S.

AU - Ungar, David R.

AU - Prakash, Devina

AU - Dole, Mukund G.

AU - Castle, Valerie P.

AU - Hernandez, Ramiro J.

AU - Koeppe, Robert A.

AU - Hutchinson, Raymond J.

PY - 1995/2

Y1 - 1995/2

N2 - PURPOSE: To assess the uptake of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in common and uncommon tumors in children and to develop a method for performing positron emission tomography (PET) studies in children with malignant neoplasms. MATERIALS AND METHODS: Twenty-two pediatric patients with known or suspected malignancies (27 scans) underwent FDG PET. Tumor uptake of FDG was measured on PET scans. RESULTS: Tumor uptake of FDG was detected in 17 of 21 patients with malignant disease. Neuroblastomas and their metastases (including those that did not absorb metaiodobenzyl- guanidine) intensely accumulated FDG. In a patient with Ewing sarcoma, FDG PET showed two foci of metastatic disease not evident on bone scans. In two patients, PET showed that large areas of the tumor were necrotic. CONCLUSION: FDG PET is feasible, is useful in the study of tumors in children, and may provide unique, clinically important information.

AB - PURPOSE: To assess the uptake of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in common and uncommon tumors in children and to develop a method for performing positron emission tomography (PET) studies in children with malignant neoplasms. MATERIALS AND METHODS: Twenty-two pediatric patients with known or suspected malignancies (27 scans) underwent FDG PET. Tumor uptake of FDG was measured on PET scans. RESULTS: Tumor uptake of FDG was detected in 17 of 21 patients with malignant disease. Neuroblastomas and their metastases (including those that did not absorb metaiodobenzyl- guanidine) intensely accumulated FDG. In a patient with Ewing sarcoma, FDG PET showed two foci of metastatic disease not evident on bone scans. In two patients, PET showed that large areas of the tumor were necrotic. CONCLUSION: FDG PET is feasible, is useful in the study of tumors in children, and may provide unique, clinically important information.

KW - Emission CT

KW - Neoplasms, in infants and children

KW - Radionuclides

UR - https://www.scopus.com/pages/publications/0028870533

U2 - 10.1148/radiology.194.2.7824731

DO - 10.1148/radiology.194.2.7824731

M3 - Article

C2 - 7824731

AN - SCOPUS:0028870533

SN - 0033-8419

VL - 194

SP - 495

EP - 500

JO - Radiology

JF - Radiology

IS - 2

ER -

Neoplasms in a pediatric population: 2-[F-18]-fluoro-2-deoxy-D-glucose PET studies

Abstract

Keywords

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