Neuroprotective effect of lidocaine: Is there clinical potential?

Tiandong Leng; Xiuren Gao; James P. Dilger; Jun Lin

Neuroprotective effect of lidocaine: Is there clinical potential?

Tiandong Leng
, Xiuren Gao
, James P. Dilger
, Jun Lin

Anesthesiology

Morehouse School of Medicine
First Affiliated Hospital of Sun Yat-sen University
Stony Brook University

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Local anesthetic lidocaine has been shown to be protective in animal models of focal and global ischemia as well as in in vitro hypoxic models. Lidocaine has been tested in patients for its potential protective effect on postoperative cognitive dysfunction. This mini-review summarizes the laboratory and clinical evidences and discusses its clinical applications as neuroprotective agent.

Original language	English
Pages (from-to)	9-13
Number of pages	5
Journal	International Journal of Physiology, Pathophysiology and Pharmacology
Volume	8
Issue number	1
State	Published - 2016

Keywords

Lidocaine
Neuroprotection
Postoperative cognitive dysfunction
Stroke

Cite this

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title = "Neuroprotective effect of lidocaine: Is there clinical potential?",

abstract = "Local anesthetic lidocaine has been shown to be protective in animal models of focal and global ischemia as well as in in vitro hypoxic models. Lidocaine has been tested in patients for its potential protective effect on postoperative cognitive dysfunction. This mini-review summarizes the laboratory and clinical evidences and discusses its clinical applications as neuroprotective agent.",

keywords = "Lidocaine, Neuroprotection, Postoperative cognitive dysfunction, Stroke",

author = "Tiandong Leng and Xiuren Gao and Dilger, \{James P.\} and Jun Lin",

year = "2016",

language = "English",

volume = "8",

pages = "9--13",

journal = "International Journal of Physiology, Pathophysiology and Pharmacology",

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TY - JOUR

T1 - Neuroprotective effect of lidocaine

T2 - Is there clinical potential?

AU - Leng, Tiandong

AU - Gao, Xiuren

AU - Dilger, James P.

AU - Lin, Jun

PY - 2016

Y1 - 2016

N2 - Local anesthetic lidocaine has been shown to be protective in animal models of focal and global ischemia as well as in in vitro hypoxic models. Lidocaine has been tested in patients for its potential protective effect on postoperative cognitive dysfunction. This mini-review summarizes the laboratory and clinical evidences and discusses its clinical applications as neuroprotective agent.

AB - Local anesthetic lidocaine has been shown to be protective in animal models of focal and global ischemia as well as in in vitro hypoxic models. Lidocaine has been tested in patients for its potential protective effect on postoperative cognitive dysfunction. This mini-review summarizes the laboratory and clinical evidences and discusses its clinical applications as neuroprotective agent.

KW - Lidocaine

KW - Neuroprotection

KW - Postoperative cognitive dysfunction

KW - Stroke

UR - https://www.scopus.com/pages/publications/84965000167

M3 - Review article

AN - SCOPUS:84965000167

SN - 1944-8171

VL - 8

SP - 9

EP - 13

JO - International Journal of Physiology, Pathophysiology and Pharmacology

JF - International Journal of Physiology, Pathophysiology and Pharmacology

IS - 1

ER -

Neuroprotective effect of lidocaine: Is there clinical potential?

Abstract

Keywords

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