New and efficient routes to norstatine and its analogs with high enantiomeric purity by β-Lactam Synthon Method

Iwao Ojima; Young Hoon Park; Chung Ming Sun; Thierry Brigaud; Mangzhu Zhao

doi:10.1016/0040-4039(92)89019-9

New and efficient routes to norstatine and its analogs with high enantiomeric purity by β-Lactam Synthon Method

Iwao Ojima
, Young Hoon Park
, Chung Ming Sun
, Thierry Brigaud
, Mangzhu Zhao

Chemistry

Stony Brook University

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Norstatine and its analogs, i.e., 3-amino-2-hydroxyalkanoic acids, with high enantiomeric purity are obtained through effecient asymmetric synthesis of 3-silyloxy-β-lactams by chiral enolate - imine cyclocondensation, followed by hydrolysis.

Original language	English
Pages (from-to)	5737-5740
Number of pages	4
Journal	Tetrahedron Letters
Volume	33
Issue number	39
DOIs	https://doi.org/10.1016/0040-4039(92)89019-9
State	Published - Sep 22 1992

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10.1016/0040-4039(92)89019-9

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title = "New and efficient routes to norstatine and its analogs with high enantiomeric purity by β-Lactam Synthon Method",

abstract = "Norstatine and its analogs, i.e., 3-amino-2-hydroxyalkanoic acids, with high enantiomeric purity are obtained through effecient asymmetric synthesis of 3-silyloxy-β-lactams by chiral enolate - imine cyclocondensation, followed by hydrolysis.",

author = "Iwao Ojima and \{Hoon Park\}, Young and \{Ming Sun\}, Chung and Thierry Brigaud and Mangzhu Zhao",

year = "1992",

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T1 - New and efficient routes to norstatine and its analogs with high enantiomeric purity by β-Lactam Synthon Method

AU - Ojima, Iwao

AU - Hoon Park, Young

AU - Ming Sun, Chung

AU - Brigaud, Thierry

AU - Zhao, Mangzhu

PY - 1992/9/22

Y1 - 1992/9/22

N2 - Norstatine and its analogs, i.e., 3-amino-2-hydroxyalkanoic acids, with high enantiomeric purity are obtained through effecient asymmetric synthesis of 3-silyloxy-β-lactams by chiral enolate - imine cyclocondensation, followed by hydrolysis.

AB - Norstatine and its analogs, i.e., 3-amino-2-hydroxyalkanoic acids, with high enantiomeric purity are obtained through effecient asymmetric synthesis of 3-silyloxy-β-lactams by chiral enolate - imine cyclocondensation, followed by hydrolysis.

UR - https://www.scopus.com/pages/publications/0026774792

U2 - 10.1016/0040-4039(92)89019-9

DO - 10.1016/0040-4039(92)89019-9

M3 - Article

AN - SCOPUS:0026774792

SN - 0040-4039

VL - 33

SP - 5737

EP - 5740

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 39

ER -

New and efficient routes to norstatine and its analogs with high enantiomeric purity by β-Lactam Synthon Method

Abstract

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