New antivirals exploit viral feedback tricks for a cure without resistance

Gábor Balázsi

doi:10.1016/j.cell.2022.05.023

New antivirals exploit viral feedback tricks for a cure without resistance

Gábor Balázsi

Laufer Center for Physical and Quantitative Biology

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Abstract

Many approved drugs, including antivirals, are small-molecule inhibitors of disease-causing proteins. Such inhibitors often elicit resistance during treatment. Chaturvedi et al. propose new, feedback-disruptor (FD) antivirals that efficiently cure infected cells from viruses and minimize the chance of resistance, providing a new paradigm to treat viral infections and possibly other diseases.

Original language	English
Pages (from-to)	2210-2212
Number of pages	3
Journal	Cell
Volume	185
Issue number	13
DOIs	https://doi.org/10.1016/j.cell.2022.05.023
State	Published - Jun 23 2022

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10.1016/j.cell.2022.05.023

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title = "New antivirals exploit viral feedback tricks for a cure without resistance",

abstract = "Many approved drugs, including antivirals, are small-molecule inhibitors of disease-causing proteins. Such inhibitors often elicit resistance during treatment. Chaturvedi et al. propose new, feedback-disruptor (FD) antivirals that efficiently cure infected cells from viruses and minimize the chance of resistance, providing a new paradigm to treat viral infections and possibly other diseases.",

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AU - Balázsi, Gábor

PY - 2022/6/23

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N2 - Many approved drugs, including antivirals, are small-molecule inhibitors of disease-causing proteins. Such inhibitors often elicit resistance during treatment. Chaturvedi et al. propose new, feedback-disruptor (FD) antivirals that efficiently cure infected cells from viruses and minimize the chance of resistance, providing a new paradigm to treat viral infections and possibly other diseases.

AB - Many approved drugs, including antivirals, are small-molecule inhibitors of disease-causing proteins. Such inhibitors often elicit resistance during treatment. Chaturvedi et al. propose new, feedback-disruptor (FD) antivirals that efficiently cure infected cells from viruses and minimize the chance of resistance, providing a new paradigm to treat viral infections and possibly other diseases.

UR - https://www.scopus.com/pages/publications/85132768072

U2 - 10.1016/j.cell.2022.05.023

DO - 10.1016/j.cell.2022.05.023

M3 - Comment/debate

C2 - 35750032

AN - SCOPUS:85132768072

SN - 0092-8674

VL - 185

SP - 2210

EP - 2212

JO - Cell

JF - Cell

IS - 13

ER -

New antivirals exploit viral feedback tricks for a cure without resistance

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