New photoaffinity analogs of paclitaxel

Iwao Ojima; Pierre Yves Bounaud; David G. Ahern

doi:10.1016/S0960-894X(99)00161-4

New photoaffinity analogs of paclitaxel

Iwao Ojima
, Pierre Yves Bounaud
, David G. Ahern

Chemistry

Stony Brook University
New England Nuclear Life Sci. Prod.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Two new photoreactive paclitaxel analogs bearing [³H₂]-3-(4- benzoyl)phenylpropanoyl group as the photophore as well as radiolabeling unit at the 7 and 10 positions, respectively, are developed. These new photoreactive analogs showed excellent preliminary results on the photoaffinity labeling of tubulin and P-glycoprotein.

Original language	English
Pages (from-to)	1189-1194
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(99)00161-4
State	Published - Apr 19 1999

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10.1016/S0960-894X(99)00161-4

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title = "New photoaffinity analogs of paclitaxel",

abstract = "Two new photoreactive paclitaxel analogs bearing [3H2]-3-(4- benzoyl)phenylpropanoyl group as the photophore as well as radiolabeling unit at the 7 and 10 positions, respectively, are developed. These new photoreactive analogs showed excellent preliminary results on the photoaffinity labeling of tubulin and P-glycoprotein.",

author = "Iwao Ojima and Bounaud, \{Pierre Yves\} and Ahern, \{David G.\}",

year = "1999",

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T1 - New photoaffinity analogs of paclitaxel

AU - Ojima, Iwao

AU - Bounaud, Pierre Yves

AU - Ahern, David G.

PY - 1999/4/19

Y1 - 1999/4/19

N2 - Two new photoreactive paclitaxel analogs bearing [3H2]-3-(4- benzoyl)phenylpropanoyl group as the photophore as well as radiolabeling unit at the 7 and 10 positions, respectively, are developed. These new photoreactive analogs showed excellent preliminary results on the photoaffinity labeling of tubulin and P-glycoprotein.

AB - Two new photoreactive paclitaxel analogs bearing [3H2]-3-(4- benzoyl)phenylpropanoyl group as the photophore as well as radiolabeling unit at the 7 and 10 positions, respectively, are developed. These new photoreactive analogs showed excellent preliminary results on the photoaffinity labeling of tubulin and P-glycoprotein.

UR - https://www.scopus.com/pages/publications/0033583494

U2 - 10.1016/S0960-894X(99)00161-4

DO - 10.1016/S0960-894X(99)00161-4

M3 - Article

C2 - 10328311

AN - SCOPUS:0033583494

SN - 0960-894X

VL - 9

SP - 1189

EP - 1194

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

New photoaffinity analogs of paclitaxel

Abstract

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