New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells

Iwao Ojima; Pierre Yves Bounaud; Craig Takeuchi; Paula Pera; Ralph J. Bernacki

doi:10.1016/S0960-894X(97)10218-9

New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells

Iwao Ojima
, Pierre Yves Bounaud
, Craig Takeuchi
, Paula Pera
, Ralph J. Bernacki

Chemistry

Stony Brook University
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (≤99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.

Original language	English
Pages (from-to)	189-194
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(97)10218-9
State	Published - Jan 20 1998

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10.1016/S0960-894X(97)10218-9

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title = "New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells",

abstract = "New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (≤99.8\%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.",

author = "Iwao Ojima and Bounaud, \{Pierre Yves\} and Craig Takeuchi and Paula Pera and Bernacki, \{Ralph J.\}",

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AU - Ojima, Iwao

AU - Bounaud, Pierre Yves

AU - Takeuchi, Craig

AU - Pera, Paula

AU - Bernacki, Ralph J.

PY - 1998/1/20

Y1 - 1998/1/20

N2 - New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (≤99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.

AB - New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (≤99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.

UR - https://www.scopus.com/pages/publications/0032548461

U2 - 10.1016/S0960-894X(97)10218-9

DO - 10.1016/S0960-894X(97)10218-9

M3 - Article

C2 - 9871652

AN - SCOPUS:0032548461

SN - 0960-894X

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SP - 189

EP - 194

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells

Abstract

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