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Noninvasive determination of optical properties of adult brain with frequency-domain near-infrared spectroscopy

  • Jee H. Choi
  • , Martin Wolf
  • , Ursula Wolf
  • , Chiara Polzonetti
  • , Larisa P. Safonova
  • , Rajarsi Gupta
  • , Antonios Michalos
  • , William Mantulin
  • , Enrico Gratton
  • , Vladislav Toronov
  • , Dennis Hueber
  • University of Illinois at Urbana-Champaign
  • ISS

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Absolute optical values for the human adult brain are difficult to measure due to the layered structure of head. We used long-range multi-distance frequency-domain near-infrared spectroscopy (NIRS) to measure absolute optical values of each tissue layer in the human head. We determined baseline optical values for the forehead in 30 adults (age range 21 to 50). We found that tissue oxygenation was relatively narrowly distributed (STD~3%) within the subject group, whereas hemoglobin concentrations and optical parameters had a relatively broader distribution. In addition, the distance dependence of optical and physiological parameters showed the layered structure of the human head. These measurements allowed determination of absolute optical properties in each layer of the adult head.

Original languageEnglish
Title of host publicationBiomedical Topical Meeting, BIOMED 2002
PublisherOptica Publishing Group (formerly OSA)
Pages144-147
Number of pages4
ISBN (Electronic)1557527024
StatePublished - 2002
EventBiomedical Topical Meeting, BIOMED 2002 - Miami Beach, United States
Duration: Apr 7 2002Apr 10 2002

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701

Conference

ConferenceBiomedical Topical Meeting, BIOMED 2002
Country/TerritoryUnited States
CityMiami Beach
Period04/7/0204/10/02

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