TY - JOUR
T1 - Occupation and risk of non-hodgkin lymphoma and its subtypes
T2 - A pooled analysis from the interlymph consortium
AU - t Mannetje, Andrea
AU - De Roos, Anneclaire J.
AU - Boffetta, Paolo
AU - Vermeulen, Roel
AU - Benke, Geza
AU - Fritschi, Lin
AU - Brennan, Paul
AU - Foretova, Lenka
AU - Maynadié, Marc
AU - Becker, Nikolaus
AU - Nieters, Alexandra
AU - Staines, Anthony
AU - Campagna, Marcello
AU - Chiu, Brian
AU - Clavel, Jacqueline
AU - de Sanjose, Silvia
AU - Hartge, Patricia
AU - Holly, Elizabeth A.
AU - Bracci, Paige
AU - Linet, Martha S.
AU - Monnereau, Alain
AU - Orsi, Laurent
AU - Purdue, Mark P.
AU - Rothman, Nathaniel
AU - Lan, Qing
AU - Kane, Eleanor
AU - Costantini, Adele Seniori
AU - Miligi, Lucia
AU - Spinelli, John J.
AU - Zheng, Tongzhang
AU - Cocco, Pierluigi
AU - Kricker, Anne
N1 - Publisher Copyright:
© 2016, Public Health Services, US Dept of Health and Human Services. All Rights Reserved.
PY - 2016/4
Y1 - 2016/4
N2 - Background: Various occupations have been associated with an elevated risk of non-Hodgkin lymphoma (NHL), but results have been inconsistent across studies. Objectives: We investigated occupational risk of NHL and of four common NHL subtypes with particular focus on occupations of a priori interest. Methods: We conducted a pooled analysis of 10,046 cases and 12,025 controls from 10 NHL studies participating in the InterLymph Consortium. We harmonized the occupational coding using the 1968 International Standard Classification of Occupations (ISCO-1968) and grouped occupations previously associated with NHL into 25 a priori groups. Odds ratios (ORs) adjusted for center, age, and sex were determined for NHL overall and for the following four subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), chronic lymphocytic leukemia/ small lymphocytic lymphoma (CLL/SLL), and peripheral T-cell lymphoma (PTCL). Results: We confirmed previously reported positive associations between NHL and farming occupations [field crop/vegetable farm workers OR = 1.26; 95% confidence interval (CI): 1.05, 1.51; general farm workers OR = 1.19; 95% CI: 1.03, 1.37]; we also confirmed associations of NHL with specific occupations such as women’s hairdressers (OR = 1.34; 95% CI: 1.02, 1.74), charworkers/cleaners (OR = 1.17; 95% CI: 1.01, 1.36), spray-painters (OR = 2.07; 95% CI: 1.30, 3.29), electrical wiremen (OR = 1.24; 95% CI: 1.00, 1.54), and carpenters (OR = 1.42; 95% CI: 1.04, 1.93). We observed subtype-specific associations for DLBCL and CLL/SLL in women’s hairdressers and for DLBCL and PTCL in textile workers. Conclusions: Our pooled analysis of 10 international studies adds to evidence suggesting that farming, hairdressing, and textile industry–related exposures may contribute to NHL risk. Associations with women’s hairdresser and textile occupations may be specific for certain NHL subtypes.
AB - Background: Various occupations have been associated with an elevated risk of non-Hodgkin lymphoma (NHL), but results have been inconsistent across studies. Objectives: We investigated occupational risk of NHL and of four common NHL subtypes with particular focus on occupations of a priori interest. Methods: We conducted a pooled analysis of 10,046 cases and 12,025 controls from 10 NHL studies participating in the InterLymph Consortium. We harmonized the occupational coding using the 1968 International Standard Classification of Occupations (ISCO-1968) and grouped occupations previously associated with NHL into 25 a priori groups. Odds ratios (ORs) adjusted for center, age, and sex were determined for NHL overall and for the following four subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), chronic lymphocytic leukemia/ small lymphocytic lymphoma (CLL/SLL), and peripheral T-cell lymphoma (PTCL). Results: We confirmed previously reported positive associations between NHL and farming occupations [field crop/vegetable farm workers OR = 1.26; 95% confidence interval (CI): 1.05, 1.51; general farm workers OR = 1.19; 95% CI: 1.03, 1.37]; we also confirmed associations of NHL with specific occupations such as women’s hairdressers (OR = 1.34; 95% CI: 1.02, 1.74), charworkers/cleaners (OR = 1.17; 95% CI: 1.01, 1.36), spray-painters (OR = 2.07; 95% CI: 1.30, 3.29), electrical wiremen (OR = 1.24; 95% CI: 1.00, 1.54), and carpenters (OR = 1.42; 95% CI: 1.04, 1.93). We observed subtype-specific associations for DLBCL and CLL/SLL in women’s hairdressers and for DLBCL and PTCL in textile workers. Conclusions: Our pooled analysis of 10 international studies adds to evidence suggesting that farming, hairdressing, and textile industry–related exposures may contribute to NHL risk. Associations with women’s hairdresser and textile occupations may be specific for certain NHL subtypes.
UR - https://www.scopus.com/pages/publications/84962170679
U2 - 10.1289/ehp.1409294
DO - 10.1289/ehp.1409294
M3 - Review article
C2 - 26340796
AN - SCOPUS:84962170679
SN - 0091-6765
VL - 124
SP - 396
EP - 405
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
IS - 4
ER -