Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

L. Costas; C. Infante-Rivard; J. P. Zock; M. Van Tongeren; P. Boffetta; A. Cusson; C. Robles; D. Casabonne; Y. Benavente; N. Becker; P. Brennan; L. Foretova; M. Maynadié; A. Staines; A. Nieters; P. Cocco; S. De Sanjosé

doi:10.1038/bjc.2015.83

Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

L. Costas
, C. Infante-Rivard
, J. P. Zock
, M. Van Tongeren
, P. Boffetta
, A. Cusson
, C. Robles
, D. Casabonne
, Y. Benavente
, N. Becker
, P. Brennan
, L. Foretova
, M. Maynadié
, A. Staines
, A. Nieters
, P. Cocco
, S. De Sanjosé

Family , Population and Preventative Medicine

Bellvitge Biomedical Research Institute
University of Barcelona
CIBER Epidemiología y Salud Pública (CIBERESP)
McGill University
Netherlands Institute for Health Services Research
ISGlobal
Pompeu Fabra University
Institute of Occupational Medicine
Centre Hospitalier Universitaire Sainte-Justine
German Cancer Research Center
International Agency for Research on Cancer
Masaryk Memorial Cancer Institute
Université de Bourgogne
University College Dublin
University of Freiburg
University of Cagliari

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Background: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. Methods: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. Results: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women. Conclusions: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.

Original language	English
Pages (from-to)	1251-1256
Number of pages	6
Journal	British Journal of Cancer
Volume	112
Issue number	7
DOIs	https://doi.org/10.1038/bjc.2015.83
State	Published - Mar 31 2015

Keywords

Alkylphenols
Chemicals
Endocrine disruptors
Leukaemia
Lymphoma
Pesticides
Solvents

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10.1038/bjc.2015.83

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Costas, L., Infante-Rivard, C., Zock, J. P., Van Tongeren, M., Boffetta, P., Cusson, A., Robles, C., Casabonne, D., Benavente, Y., Becker, N., Brennan, P., Foretova, L., Maynadié, M., Staines, A., Nieters, A., Cocco, P., & De Sanjosé, S. (2015). Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study. British Journal of Cancer, 112(7), 1251-1256. https://doi.org/10.1038/bjc.2015.83

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title = "Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study",

abstract = "Background: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. Methods: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. Results: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24\% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women. Conclusions: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.",

keywords = "Alkylphenols, Chemicals, Endocrine disruptors, Leukaemia, Lymphoma, Pesticides, Solvents",

author = "L. Costas and C. Infante-Rivard and Zock, \{J. P.\} and \{Van Tongeren\}, M. and P. Boffetta and A. Cusson and C. Robles and D. Casabonne and Y. Benavente and N. Becker and P. Brennan and L. Foretova and M. Maynadi{\'e} and A. Staines and A. Nieters and P. Cocco and \{De Sanjos{\'e}\}, S.",

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Costas, L, Infante-Rivard, C, Zock, JP, Van Tongeren, M, Boffetta, P, Cusson, A, Robles, C, Casabonne, D, Benavente, Y, Becker, N, Brennan, P, Foretova, L, Maynadié, M, Staines, A, Nieters, A, Cocco, P & De Sanjosé, S 2015, 'Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study', British Journal of Cancer, vol. 112, no. 7, pp. 1251-1256. https://doi.org/10.1038/bjc.2015.83

TY - JOUR

T1 - Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

AU - Costas, L.

AU - Infante-Rivard, C.

AU - Zock, J. P.

AU - Van Tongeren, M.

AU - Boffetta, P.

AU - Cusson, A.

AU - Robles, C.

AU - Casabonne, D.

AU - Benavente, Y.

AU - Becker, N.

AU - Brennan, P.

AU - Foretova, L.

AU - Maynadié, M.

AU - Staines, A.

AU - Nieters, A.

AU - Cocco, P.

AU - De Sanjosé, S.

PY - 2015/3/31

Y1 - 2015/3/31

N2 - Background: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. Methods: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. Results: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women. Conclusions: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.

AB - Background: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. Methods: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. Results: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women. Conclusions: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.

KW - Alkylphenols

KW - Chemicals

KW - Endocrine disruptors

KW - Leukaemia

KW - Lymphoma

KW - Pesticides

KW - Solvents

UR - https://www.scopus.com/pages/publications/84938554649

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DO - 10.1038/bjc.2015.83

M3 - Article

C2 - 25742473

AN - SCOPUS:84938554649

SN - 0007-0920

VL - 112

SP - 1251

EP - 1256

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 7

ER -

Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

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