TY - JOUR
T1 - Occupational exposures and odds of gastric cancer
T2 - A StoP project consortium pooled analysis
AU - Shah, Shailja C.
AU - Boffetta, Paolo
AU - Johnson, Kenneth C.
AU - Hu, Jinfu
AU - Palli, Domenico
AU - Ferraroni, Monica
AU - Tsugane, Shoichiro
AU - Hamada, Gerson Shigueaki
AU - Hidaka, Akihisa
AU - Zaridze, David
AU - Maximovich, Dmitry
AU - Vioque, Jesus
AU - Navarrete-Munoz, Eva M.
AU - Zhang, Zuo Feng
AU - Mu, Lina
AU - Boccia, Stefania
AU - Pastorino, Roberta
AU - Kurtz, Robert C.
AU - Rota, Matteo
AU - Bonzi, Rossella
AU - Negri, Eva
AU - la Vecchia, Carlo
AU - Pelucchi, Claudio
AU - Hashim, Dana
N1 - Publisher Copyright:
© The Author(s) 2020; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association
PY - 2021
Y1 - 2021
N2 - Background: Gastric cancer pathogenesis represents a complex interaction of host genetic determinants, microbial virulence factors and environmental exposures. Our primary aim was to determine the association between occupations/occupational exposures and odds of gastric cancer. Methods: We conducted a pooled-analysis of individual-level data harmonized from 11 studies in the Stomach cancer Pooling Project. Multivariable logistic regression was used to estimate the odds ratio (OR) of gastric cancer adjusted for relevant confounders. Results: A total of 5279 gastric cancer cases and 12 297 controls were analysed. There were higher odds of gastric cancer among labour-related occupations, including: agricultural and animal husbandry workers [odds ratio (OR) 1.33, 95% confidence interval (CI): 1.06-1.68]; miners, quarrymen, well-drillers and related workers (OR 1.70, 95% CI: 1.01-2.88); blacksmiths, toolmakers and machine-tool operators (OR 1.41, 95% CI: 1.05-1.89); bricklayers, carpenters and construction workers (OR 1.30, 95% CI: 1.06-1.60); and stationary engine and related equipment operators (OR 6.53, 95% CI: 1.41-30.19). The ORs for wood-dust exposure were 1.51 (95% CI: 1.01-2.26) for intestinal-type and 2.52 (95% CI: 1.46-4.33) for diffuse-type gastric cancer. Corresponding values for aromatic amine exposure were 1.83 (95% CI: 1.09-3.06) and 2.92 (95% CI: 1.36-6.26). Exposure to coal derivatives, pesticides/herbicides, chromium, radiation and magnetic fields were associated with higher odds of diffuse-type, but not intestinal-type gastric cancer. Conclusions: Based on a large pooled analysis, we identified several occupations and related exposures that are associated with elevated odds of gastric cancer. These findings have potential implications for risk attenuation and could be used to direct investigations evaluating the impact of targeted gastric cancer prevention/early detection programmes based on occupation.
AB - Background: Gastric cancer pathogenesis represents a complex interaction of host genetic determinants, microbial virulence factors and environmental exposures. Our primary aim was to determine the association between occupations/occupational exposures and odds of gastric cancer. Methods: We conducted a pooled-analysis of individual-level data harmonized from 11 studies in the Stomach cancer Pooling Project. Multivariable logistic regression was used to estimate the odds ratio (OR) of gastric cancer adjusted for relevant confounders. Results: A total of 5279 gastric cancer cases and 12 297 controls were analysed. There were higher odds of gastric cancer among labour-related occupations, including: agricultural and animal husbandry workers [odds ratio (OR) 1.33, 95% confidence interval (CI): 1.06-1.68]; miners, quarrymen, well-drillers and related workers (OR 1.70, 95% CI: 1.01-2.88); blacksmiths, toolmakers and machine-tool operators (OR 1.41, 95% CI: 1.05-1.89); bricklayers, carpenters and construction workers (OR 1.30, 95% CI: 1.06-1.60); and stationary engine and related equipment operators (OR 6.53, 95% CI: 1.41-30.19). The ORs for wood-dust exposure were 1.51 (95% CI: 1.01-2.26) for intestinal-type and 2.52 (95% CI: 1.46-4.33) for diffuse-type gastric cancer. Corresponding values for aromatic amine exposure were 1.83 (95% CI: 1.09-3.06) and 2.92 (95% CI: 1.36-6.26). Exposure to coal derivatives, pesticides/herbicides, chromium, radiation and magnetic fields were associated with higher odds of diffuse-type, but not intestinal-type gastric cancer. Conclusions: Based on a large pooled analysis, we identified several occupations and related exposures that are associated with elevated odds of gastric cancer. These findings have potential implications for risk attenuation and could be used to direct investigations evaluating the impact of targeted gastric cancer prevention/early detection programmes based on occupation.
KW - Digestive system neoplasm
KW - Environment and public health
KW - Epidemiology
KW - Gastric neoplasm
UR - https://www.scopus.com/pages/publications/85085905412
U2 - 10.1093/IJE/DYZ263
DO - 10.1093/IJE/DYZ263
M3 - Article
C2 - 31965145
AN - SCOPUS:85085905412
SN - 0300-5771
VL - 49
SP - 422
EP - 434
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 2
ER -