Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Prerna Khetan; Paolo Boffetta; Daniele Luce; Isabelle Stucker; Maria Paula Curado; Ana Menezes; Victor Wunsch-Filho; Wolfgang Ahrens; Pagona Lagiou; Diego Serraino; Lorenzo Richiardi; Kristina Kjaerheim; David Conway; Peter Thomson; Joshua Muscat; Dana Mates; Heribert Ramroth; Gwenn Menvielle; Thomas L. Vaughan; Hermann Brenner; Yuan Chin Amy Lee; Carlo La Vecchia; Mia Hashibe; Dana Hashim

doi:10.1097/JOM.0000000000001563

Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Prerna Khetan
, Paolo Boffetta
, Daniele Luce
, Isabelle Stucker
, Maria Paula Curado
, Ana Menezes
, Victor Wunsch-Filho
, Wolfgang Ahrens
, Pagona Lagiou
, Diego Serraino
, Lorenzo Richiardi
, Kristina Kjaerheim
, David Conway
, Peter Thomson
, Joshua Muscat
, Dana Mates
, Heribert Ramroth
, Gwenn Menvielle
, Thomas L. Vaughan
, Hermann Brenner

Yuan Chin Amy Lee, Carlo La Vecchia, Mia Hashibe, Dana Hashim

Family , Population and Preventative Medicine

Icahn School of Medicine at Mount Sinai
Université de Rennes
National Institutes of Health
Université Paris-Saclay
Universidade Federal de Pelotas
Universidade de São Paulo
Leibniz Institute for Prevention Research and Epidemiology
National and Kapodistrian University of Athens
Institute of Scientific Characterization and Hospitalization
University of Turin
Cancer Registry of Norway Institute of Population-Based Cancer Research
University of Glasgow
The University of Hong Kong
Pennsylvania State University
National Institute of Public Health
Heidelberg University
Sorbonne Université
Fred Hutchinson Cancer Research Center
German Cancer Research Center
University of Utah
University of Milan

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Objective:To investigate the associations between head and neck cancer (HNC) risk and occupations.Methods:We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula P_EC×(OR-1)/OR.¹Results:Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR=1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR=1.38; 95% CI 1.13 to 1.69), painters (OR=1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC.Conclusions:We found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship.

Original language	English
Pages (from-to)	397-404
Number of pages	8
Journal	Journal of Occupational and Environmental Medicine
Volume	61
Issue number	5
DOIs	https://doi.org/10.1097/JOM.0000000000001563
State	Published - May 1 2019

Keywords

Cancer
Head
Larynx
Neck
Occupation
Pooled

Access to Document

10.1097/JOM.0000000000001563

Cite this

Khetan, P., Boffetta, P., Luce, D., Stucker, I., Curado, M. P., Menezes, A., Wunsch-Filho, V., Ahrens, W., Lagiou, P., Serraino, D., Richiardi, L., Kjaerheim, K., Conway, D., Thomson, P., Muscat, J., Mates, D., Ramroth, H., Menvielle, G., Vaughan, T. L., ... Hashim, D. (2019). Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Journal of Occupational and Environmental Medicine, 61(5), 397-404. https://doi.org/10.1097/JOM.0000000000001563

@article{4130093e04f3430aacdd874813515df3,

title = "Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium",

abstract = "Objective:To investigate the associations between head and neck cancer (HNC) risk and occupations.Methods:We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC×(OR-1)/OR.1Results:Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR=1.36; 95\% confidence interval [CI] 1.09 to 1.68), cleaners (OR=1.38; 95\% CI 1.13 to 1.69), painters (OR=1.82; 95\% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5\% (95\% CI 7.1\% to 21.9\%) for HNC.Conclusions:We found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship.",

keywords = "Cancer, Head, Larynx, Neck, Occupation, Pooled",

author = "Prerna Khetan and Paolo Boffetta and Daniele Luce and Isabelle Stucker and Curado, \{Maria Paula\} and Ana Menezes and Victor Wunsch-Filho and Wolfgang Ahrens and Pagona Lagiou and Diego Serraino and Lorenzo Richiardi and Kristina Kjaerheim and David Conway and Peter Thomson and Joshua Muscat and Dana Mates and Heribert Ramroth and Gwenn Menvielle and Vaughan, \{Thomas L.\} and Hermann Brenner and Lee, \{Yuan Chin Amy\} and \{La Vecchia\}, Carlo and Mia Hashibe and Dana Hashim",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 American College of Occupational and Environmental Medicine.",

year = "2019",

month = may,

day = "1",

doi = "10.1097/JOM.0000000000001563",

language = "English",

volume = "61",

pages = "397--404",

journal = "Journal of Occupational and Environmental Medicine",

issn = "1076-2752",

number = "5",

}

Khetan, P, Boffetta, P, Luce, D, Stucker, I, Curado, MP, Menezes, A, Wunsch-Filho, V, Ahrens, W, Lagiou, P, Serraino, D, Richiardi, L, Kjaerheim, K, Conway, D, Thomson, P, Muscat, J, Mates, D, Ramroth, H, Menvielle, G, Vaughan, TL, Brenner, H, Lee, YCA, La Vecchia, C, Hashibe, M & Hashim, D 2019, 'Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium', Journal of Occupational and Environmental Medicine, vol. 61, no. 5, pp. 397-404. https://doi.org/10.1097/JOM.0000000000001563

TY - JOUR

T1 - Occupations and the Risk of Head and Neck Cancer

T2 - A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

AU - Khetan, Prerna

AU - Boffetta, Paolo

AU - Luce, Daniele

AU - Stucker, Isabelle

AU - Curado, Maria Paula

AU - Menezes, Ana

AU - Wunsch-Filho, Victor

AU - Ahrens, Wolfgang

AU - Lagiou, Pagona

AU - Serraino, Diego

AU - Richiardi, Lorenzo

AU - Kjaerheim, Kristina

AU - Conway, David

AU - Thomson, Peter

AU - Muscat, Joshua

AU - Mates, Dana

AU - Ramroth, Heribert

AU - Menvielle, Gwenn

AU - Vaughan, Thomas L.

AU - Brenner, Hermann

AU - Lee, Yuan Chin Amy

AU - La Vecchia, Carlo

AU - Hashibe, Mia

AU - Hashim, Dana

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Objective:To investigate the associations between head and neck cancer (HNC) risk and occupations.Methods:We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC×(OR-1)/OR.1Results:Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR=1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR=1.38; 95% CI 1.13 to 1.69), painters (OR=1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC.Conclusions:We found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship.

AB - Objective:To investigate the associations between head and neck cancer (HNC) risk and occupations.Methods:We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC×(OR-1)/OR.1Results:Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR=1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR=1.38; 95% CI 1.13 to 1.69), painters (OR=1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC.Conclusions:We found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship.

KW - Cancer

KW - Head

KW - Larynx

KW - Neck

KW - Occupation

KW - Pooled

UR - https://www.scopus.com/pages/publications/85069267777

U2 - 10.1097/JOM.0000000000001563

DO - 10.1097/JOM.0000000000001563

M3 - Article

C2 - 31268937

AN - SCOPUS:85069267777

SN - 1076-2752

VL - 61

SP - 397

EP - 404

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

IS - 5

ER -

Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this