Oligoclonal IgG in tears

P. K. Coyle; Patrick Sibony; Cynthia Johnson

doi:10.1212/wnl.37.5.853

Oligoclonal IgG in tears

P. K. Coyle
, Patrick Sibony
, Cynthia Johnson

Stony Brook University

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We examined tears from patients with MS and systemic or eye diseases, and normal controls. Tears were isoelectrofocused on agarose gel, silver-stained, and immunofixated for IgG. In the cathodal portion of the gel (pH ≥ 8.3), oligoclonal bands were detected in 14 of 21 (67%) MS tear samples. In most cases, these bands were not present in serum. Only 1 of 26 non-MS subjects showed two faint IgG tear bands, which were strongly present in serum. It appears that oligoclonal IgG bands can be detected in tears as well as in CSF of MS patients.

Original language	English
Pages (from-to)	853-856
Number of pages	4
Journal	Neurology
Volume	37
Issue number	5
DOIs	https://doi.org/10.1212/wnl.37.5.853
State	Published - May 1987

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title = "Oligoclonal IgG in tears",

abstract = "We examined tears from patients with MS and systemic or eye diseases, and normal controls. Tears were isoelectrofocused on agarose gel, silver-stained, and immunofixated for IgG. In the cathodal portion of the gel (pH ≥ 8.3), oligoclonal bands were detected in 14 of 21 (67\%) MS tear samples. In most cases, these bands were not present in serum. Only 1 of 26 non-MS subjects showed two faint IgG tear bands, which were strongly present in serum. It appears that oligoclonal IgG bands can be detected in tears as well as in CSF of MS patients.",

author = "Coyle, \{P. K.\} and Patrick Sibony and Cynthia Johnson",

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AU - Coyle, P. K.

AU - Sibony, Patrick

AU - Johnson, Cynthia

PY - 1987/5

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N2 - We examined tears from patients with MS and systemic or eye diseases, and normal controls. Tears were isoelectrofocused on agarose gel, silver-stained, and immunofixated for IgG. In the cathodal portion of the gel (pH ≥ 8.3), oligoclonal bands were detected in 14 of 21 (67%) MS tear samples. In most cases, these bands were not present in serum. Only 1 of 26 non-MS subjects showed two faint IgG tear bands, which were strongly present in serum. It appears that oligoclonal IgG bands can be detected in tears as well as in CSF of MS patients.

AB - We examined tears from patients with MS and systemic or eye diseases, and normal controls. Tears were isoelectrofocused on agarose gel, silver-stained, and immunofixated for IgG. In the cathodal portion of the gel (pH ≥ 8.3), oligoclonal bands were detected in 14 of 21 (67%) MS tear samples. In most cases, these bands were not present in serum. Only 1 of 26 non-MS subjects showed two faint IgG tear bands, which were strongly present in serum. It appears that oligoclonal IgG bands can be detected in tears as well as in CSF of MS patients.

UR - https://www.scopus.com/pages/publications/0023273897

U2 - 10.1212/wnl.37.5.853

DO - 10.1212/wnl.37.5.853

M3 - Article

C2 - 3574689

AN - SCOPUS:0023273897

SN - 0028-3878

VL - 37

SP - 853

EP - 856

JO - Neurology

JF - Neurology

IS - 5

ER -

Oligoclonal IgG in tears

Abstract

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