Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

Jing Li; Ying Yang; Yue Peng; Richard J. Austin; Winfried G. Van Eyndhoven; Ken C.Q. Nguyen; Tim Gabriele; Mila E. McCurrach; Jeffrey R. Marks; Timothy Hoey; Scott W. Lowe; Scott Powers

doi:10.1038/ng888

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

Jing Li
, Ying Yang
, Yue Peng
, Richard J. Austin
, Winfried G. Van Eyndhoven
, Ken C.Q. Nguyen
, Tim Gabriele
, Mila E. McCurrach
, Jeffrey R. Marks
, Timothy Hoey
, Scott W. Lowe
, Scott Powers

Pathology

Tularik Inc.
Amgen Incorporated
Cold Spring Harbor Laboratory
Duke University

Research output: Contribution to journal › Article › peer-review

225 Scopus citations

Abstract

We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.

Original language	English
Pages (from-to)	133-134
Number of pages	2
Journal	Nature Genetics
Volume	31
Issue number	2
DOIs	https://doi.org/10.1038/ng888
State	Published - Jun 2002

Access to Document

10.1038/ng888

Cite this

@article{5ee3c070742c4041bcd06abf81605a5a,

title = "Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23",

abstract = "We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.",

author = "Jing Li and Ying Yang and Yue Peng and Austin, \{Richard J.\} and \{Van Eyndhoven\}, \{Winfried G.\} and Nguyen, \{Ken C.Q.\} and Tim Gabriele and McCurrach, \{Mila E.\} and Marks, \{Jeffrey R.\} and Timothy Hoey and Lowe, \{Scott W.\} and Scott Powers",

year = "2002",

month = jun,

doi = "10.1038/ng888",

language = "English",

volume = "31",

pages = "133--134",

journal = "Nature Genetics",

issn = "1061-4036",

number = "2",

}

TY - JOUR

T1 - Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

AU - Li, Jing

AU - Yang, Ying

AU - Peng, Yue

AU - Austin, Richard J.

AU - Van Eyndhoven, Winfried G.

AU - Nguyen, Ken C.Q.

AU - Gabriele, Tim

AU - McCurrach, Mila E.

AU - Marks, Jeffrey R.

AU - Hoey, Timothy

AU - Lowe, Scott W.

AU - Powers, Scott

PY - 2002/6

Y1 - 2002/6

N2 - We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.

AB - We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.

UR - https://www.scopus.com/pages/publications/18544385947

U2 - 10.1038/ng888

DO - 10.1038/ng888

M3 - Article

C2 - 12021784

AN - SCOPUS:18544385947

SN - 1061-4036

VL - 31

SP - 133

EP - 134

JO - Nature Genetics

JF - Nature Genetics

IS - 2

ER -

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

Abstract

Access to Document

Other files and links

Fingerprint

Cite this