One-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles by a tandem three-component reaction of hydroxylamines, aldehydes and 2-azido acrylates

Bao Hu; Ning Ai; Zhao Wang; Xiaoliang Xu; Xiaonian Li

doi:10.3998/ark.5550190.0013.621

One-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles by a tandem three-component reaction of hydroxylamines, aldehydes and 2-azido acrylates

Bao Hu
, Ning Ai
, Zhao Wang
, Xiaoliang Xu
, Xiaonian Li

Psychiatry

Zhejiang University of Technology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The reaction of nitrones, formed in situ by reaction of hydroxylamines and aldehydes, with 2- azido acrylates results in the formation of 1,2,4,5-tetrasubstituted imidazoles has been developed. This three-component reaction allows for the formation of a diverse array of imidazole derivatives with moderate to excellent yields.

Original language	English
Pages (from-to)	222-228
Number of pages	7
Journal	Arkivoc
Volume	2012
Issue number	6
DOIs	https://doi.org/10.3998/ark.5550190.0013.621
State	Published - Apr 16 2012

Keywords

2-azido acrylates
Aldehydes
Hydroxylamines
Imidazoles
Multicomponent reactions

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10.3998/ark.5550190.0013.621

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title = "One-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles by a tandem three-component reaction of hydroxylamines, aldehydes and 2-azido acrylates",

abstract = "The reaction of nitrones, formed in situ by reaction of hydroxylamines and aldehydes, with 2- azido acrylates results in the formation of 1,2,4,5-tetrasubstituted imidazoles has been developed. This three-component reaction allows for the formation of a diverse array of imidazole derivatives with moderate to excellent yields.",

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AU - Hu, Bao

AU - Ai, Ning

AU - Wang, Zhao

AU - Xu, Xiaoliang

AU - Li, Xiaonian

PY - 2012/4/16

Y1 - 2012/4/16

N2 - The reaction of nitrones, formed in situ by reaction of hydroxylamines and aldehydes, with 2- azido acrylates results in the formation of 1,2,4,5-tetrasubstituted imidazoles has been developed. This three-component reaction allows for the formation of a diverse array of imidazole derivatives with moderate to excellent yields.

AB - The reaction of nitrones, formed in situ by reaction of hydroxylamines and aldehydes, with 2- azido acrylates results in the formation of 1,2,4,5-tetrasubstituted imidazoles has been developed. This three-component reaction allows for the formation of a diverse array of imidazole derivatives with moderate to excellent yields.

KW - 2-azido acrylates

KW - Aldehydes

KW - Hydroxylamines

KW - Imidazoles

KW - Multicomponent reactions

UR - https://www.scopus.com/pages/publications/84860185990

U2 - 10.3998/ark.5550190.0013.621

DO - 10.3998/ark.5550190.0013.621

M3 - Article

AN - SCOPUS:84860185990

SN - 1551-7012

VL - 2012

SP - 222

EP - 228

JO - Arkivoc

JF - Arkivoc

IS - 6

ER -

One-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles by a tandem three-component reaction of hydroxylamines, aldehydes and 2-azido acrylates

Abstract

Keywords

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