On/off regulation of gene expression at the level of splicing

Paul M. Bingham; Tze Bin Chou; Inka Mims; Zuzana Zachar

doi:10.1016/0168-9525(88)90136-9

On/off regulation of gene expression at the level of splicing

Paul M. Bingham
, Tze Bin Chou
, Inka Mims
, Zuzana Zachar

Biochemistry and Cell Biology

Stony Brook University

Research output: Contribution to journal › Review article › peer-review

144 Scopus citations

Abstract

The past two years have seen the discovery of three independent cases in which expression of a eukaryotic protein gene product is turned on and off by controlling splicing events necessary to produce the corresponding mRNA. Various considerations suggest that such on/off regulation at the level of splicing may be unexpectedly common.

Original language	English
Pages (from-to)	134-138
Number of pages	5
Journal	Trends in Genetics
Volume	4
Issue number	5
DOIs	https://doi.org/10.1016/0168-9525(88)90136-9
State	Published - May 1988

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title = "On/off regulation of gene expression at the level of splicing",

abstract = "The past two years have seen the discovery of three independent cases in which expression of a eukaryotic protein gene product is turned on and off by controlling splicing events necessary to produce the corresponding mRNA. Various considerations suggest that such on/off regulation at the level of splicing may be unexpectedly common.",

author = "Bingham, \{Paul M.\} and Chou, \{Tze Bin\} and Inka Mims and Zuzana Zachar",

year = "1988",

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doi = "10.1016/0168-9525(88)90136-9",

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T1 - On/off regulation of gene expression at the level of splicing

AU - Bingham, Paul M.

AU - Chou, Tze Bin

AU - Mims, Inka

AU - Zachar, Zuzana

PY - 1988/5

Y1 - 1988/5

N2 - The past two years have seen the discovery of three independent cases in which expression of a eukaryotic protein gene product is turned on and off by controlling splicing events necessary to produce the corresponding mRNA. Various considerations suggest that such on/off regulation at the level of splicing may be unexpectedly common.

AB - The past two years have seen the discovery of three independent cases in which expression of a eukaryotic protein gene product is turned on and off by controlling splicing events necessary to produce the corresponding mRNA. Various considerations suggest that such on/off regulation at the level of splicing may be unexpectedly common.

UR - https://www.scopus.com/pages/publications/0023824450

U2 - 10.1016/0168-9525(88)90136-9

DO - 10.1016/0168-9525(88)90136-9

M3 - Review article

C2 - 2853467

AN - SCOPUS:0023824450

SN - 0168-9525

VL - 4

SP - 134

EP - 138

JO - Trends in Genetics

JF - Trends in Genetics

IS - 5

ER -

On/off regulation of gene expression at the level of splicing

Abstract

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