Opium use and the risk of head and neck squamous cell carcinoma

Elham Mohebbi; Maryam Hadji; Hamideh Rashidian; Abass Rezaianzadeh; Maryam Marzban; Ali Akbar Haghdoost; Ahmad Naghibzadeh Tahami; Abdolvahab Moradi; Mahin Gholipour; Farid Najafi; Roya Safari-Faramani; Reza Alizadeh-Navaei; Alireza Ansari-Moghaddam; Mahdieh Bakhshi; Azim Nejatizadeh; Masumeh Mahmoudi; Soodabeh Shahidsales; Saeideh Ahmadi-Simab; Ali Asghar Arabi Mianroodi; Monireh Sadat Seyyedsalehi; Bayan Hosseini; Vahideh Peyghambari; Mohammad Shirkhoda; Reza Shirkoohi; Elmira Ebrahimi; Soheila Manifar; Mohammad Ali Mohagheghi; Laura Rozek; Paul Brennan; Hossein Poustchi; Arash Etemadi; Eero Pukkala; Joachim Schüz; Reza Malekzadeh; Elisabete Weiderpass; Afarin Rahimi-Movaghar; Paolo Boffetta; Farin Kamanagar; Kazem Zendehdel

doi:10.1002/ijc.33289

Opium use and the risk of head and neck squamous cell carcinoma

Elham Mohebbi
, Maryam Hadji
, Hamideh Rashidian
, Abass Rezaianzadeh
, Maryam Marzban
, Ali Akbar Haghdoost
, Ahmad Naghibzadeh Tahami
, Abdolvahab Moradi
, Mahin Gholipour
, Farid Najafi
, Roya Safari-Faramani
, Reza Alizadeh-Navaei
, Alireza Ansari-Moghaddam
, Mahdieh Bakhshi
, Azim Nejatizadeh
, Masumeh Mahmoudi
, Soodabeh Shahidsales
, Saeideh Ahmadi-Simab
, Ali Asghar Arabi Mianroodi
, Monireh Sadat Seyyedsalehi

Bayan Hosseini, Vahideh Peyghambari, Mohammad Shirkhoda, Reza Shirkoohi, Elmira Ebrahimi, Soheila Manifar, Mohammad Ali Mohagheghi, Laura Rozek, Paul Brennan, Hossein Poustchi, Arash Etemadi, Eero Pukkala, Joachim Schüz, Reza Malekzadeh, Elisabete Weiderpass, Afarin Rahimi-Movaghar, Paolo Boffetta, Farin Kamanagar, Kazem Zendehdel

Family , Population and Preventative Medicine

Tehran University of Medical Sciences
Kerman University of Medical Sciences
Tampere University
Shiraz University of Medical Sciences
Bushehr University of Medical Sciences
Golestan University of Medical Sciences
Kermanshah University of Medical Sciences
Mazandaran University of Medical Sciences
Zahedan University of Medical Sciences
Hormozgan University of Medical Sciences
Mashhad University of Medical Sciences
International Agency for Research on Cancer
University of Michigan, Ann Arbor
National Institutes of Health
Finnish Cancer Registry
Morgan State University

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Scant evidence exists to support the association of opium use with head and neck cancer, limited to the larynx and oral cavity. In a multicenter case-control study—Iran Opium and Cancer study, we recruited 633 cases of head and neck squamous cell carcinoma (HNSCC) (254 lip and oral cavity, 54 pharynx, 327 larynx and 28 other subsites within the head and neck) and 3065 frequency-matched controls from April 2016 to April 2019. Odds ratios (ORs) for opium use and 95% confidence intervals (95% CIs) were obtained using mixed-effects logistic regression because of heterogeneity among centers. The adjusted OR (95% CI) for regular opium use was 3.76 (2.96-4.79) for all HNSCC combined. Strong dose-response effects were observed by frequency or amount of use, and duration of use. Regular opium uses significantly increased the risk of HNSCC of the pharynx, larynx and other subsites within the head and neck with OR (95% CI) of 2.90 (1.40-6.02), 6.55 (4.69-9.13) and 5.95 (2.41-14.71), respectively. The observed associations were significant even among never tobacco smokers (including cigarette and water-pipe smoking). Moreover, by the multiplicative interaction scale, the effect of opium use could be varied by cigarette smoking on HNSCC, 8.16 (6.20-10.74). For the first time, the current study showed opium users have an increased risk of several anatomic subsites of HNSCC.

Original language	English
Pages (from-to)	1066-1076
Number of pages	11
Journal	International Journal of Cancer
Volume	148
Issue number	5
DOIs	https://doi.org/10.1002/ijc.33289
State	Published - Mar 1 2021

Keywords

drug-related disorders
morphine
neoplasm
opium
otorhinolaryngologic neoplasms

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Mohebbi, E., Hadji, M., Rashidian, H., Rezaianzadeh, A., Marzban, M., Haghdoost, A. A., Naghibzadeh Tahami, A., Moradi, A., Gholipour, M., Najafi, F., Safari-Faramani, R., Alizadeh-Navaei, R., Ansari-Moghaddam, A., Bakhshi, M., Nejatizadeh, A., Mahmoudi, M., Shahidsales, S., Ahmadi-Simab, S., Arabi Mianroodi, A. A., ... Zendehdel, K. (2021). Opium use and the risk of head and neck squamous cell carcinoma. International Journal of Cancer, 148(5), 1066-1076. https://doi.org/10.1002/ijc.33289

@article{613c7960de0745d8b54797e5729d6ded,

title = "Opium use and the risk of head and neck squamous cell carcinoma",

abstract = "Scant evidence exists to support the association of opium use with head and neck cancer, limited to the larynx and oral cavity. In a multicenter case-control study—Iran Opium and Cancer study, we recruited 633 cases of head and neck squamous cell carcinoma (HNSCC) (254 lip and oral cavity, 54 pharynx, 327 larynx and 28 other subsites within the head and neck) and 3065 frequency-matched controls from April 2016 to April 2019. Odds ratios (ORs) for opium use and 95\% confidence intervals (95\% CIs) were obtained using mixed-effects logistic regression because of heterogeneity among centers. The adjusted OR (95\% CI) for regular opium use was 3.76 (2.96-4.79) for all HNSCC combined. Strong dose-response effects were observed by frequency or amount of use, and duration of use. Regular opium uses significantly increased the risk of HNSCC of the pharynx, larynx and other subsites within the head and neck with OR (95\% CI) of 2.90 (1.40-6.02), 6.55 (4.69-9.13) and 5.95 (2.41-14.71), respectively. The observed associations were significant even among never tobacco smokers (including cigarette and water-pipe smoking). Moreover, by the multiplicative interaction scale, the effect of opium use could be varied by cigarette smoking on HNSCC, 8.16 (6.20-10.74). For the first time, the current study showed opium users have an increased risk of several anatomic subsites of HNSCC.",

keywords = "drug-related disorders, morphine, neoplasm, opium, otorhinolaryngologic neoplasms",

author = "Elham Mohebbi and Maryam Hadji and Hamideh Rashidian and Abass Rezaianzadeh and Maryam Marzban and Haghdoost, \{Ali Akbar\} and \{Naghibzadeh Tahami\}, Ahmad and Abdolvahab Moradi and Mahin Gholipour and Farid Najafi and Roya Safari-Faramani and Reza Alizadeh-Navaei and Alireza Ansari-Moghaddam and Mahdieh Bakhshi and Azim Nejatizadeh and Masumeh Mahmoudi and Soodabeh Shahidsales and Saeideh Ahmadi-Simab and \{Arabi Mianroodi\}, \{Ali Asghar\} and Seyyedsalehi, \{Monireh Sadat\} and Bayan Hosseini and Vahideh Peyghambari and Mohammad Shirkhoda and Reza Shirkoohi and Elmira Ebrahimi and Soheila Manifar and Mohagheghi, \{Mohammad Ali\} and Laura Rozek and Paul Brennan and Hossein Poustchi and Arash Etemadi and Eero Pukkala and Joachim Sch{\"u}z and Reza Malekzadeh and Elisabete Weiderpass and Afarin Rahimi-Movaghar and Paolo Boffetta and Farin Kamanagar and Kazem Zendehdel",

note = "Publisher Copyright: {\textcopyright} 2020 UICC",

year = "2021",

month = mar,

day = "1",

doi = "10.1002/ijc.33289",

language = "English",

volume = "148",

pages = "1066--1076",

journal = "International Journal of Cancer",

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Mohebbi, E, Hadji, M, Rashidian, H, Rezaianzadeh, A, Marzban, M, Haghdoost, AA, Naghibzadeh Tahami, A, Moradi, A, Gholipour, M, Najafi, F, Safari-Faramani, R, Alizadeh-Navaei, R, Ansari-Moghaddam, A, Bakhshi, M, Nejatizadeh, A, Mahmoudi, M, Shahidsales, S, Ahmadi-Simab, S, Arabi Mianroodi, AA, Seyyedsalehi, MS, Hosseini, B, Peyghambari, V, Shirkhoda, M, Shirkoohi, R, Ebrahimi, E, Manifar, S, Mohagheghi, MA, Rozek, L, Brennan, P, Poustchi, H, Etemadi, A, Pukkala, E, Schüz, J, Malekzadeh, R, Weiderpass, E, Rahimi-Movaghar, A, Boffetta, P, Kamanagar, F & Zendehdel, K 2021, 'Opium use and the risk of head and neck squamous cell carcinoma', International Journal of Cancer, vol. 148, no. 5, pp. 1066-1076. https://doi.org/10.1002/ijc.33289

TY - JOUR

T1 - Opium use and the risk of head and neck squamous cell carcinoma

AU - Mohebbi, Elham

AU - Hadji, Maryam

AU - Rashidian, Hamideh

AU - Rezaianzadeh, Abass

AU - Marzban, Maryam

AU - Haghdoost, Ali Akbar

AU - Naghibzadeh Tahami, Ahmad

AU - Moradi, Abdolvahab

AU - Gholipour, Mahin

AU - Najafi, Farid

AU - Safari-Faramani, Roya

AU - Alizadeh-Navaei, Reza

AU - Ansari-Moghaddam, Alireza

AU - Bakhshi, Mahdieh

AU - Nejatizadeh, Azim

AU - Mahmoudi, Masumeh

AU - Shahidsales, Soodabeh

AU - Ahmadi-Simab, Saeideh

AU - Arabi Mianroodi, Ali Asghar

AU - Seyyedsalehi, Monireh Sadat

AU - Hosseini, Bayan

AU - Peyghambari, Vahideh

AU - Shirkhoda, Mohammad

AU - Shirkoohi, Reza

AU - Ebrahimi, Elmira

AU - Manifar, Soheila

AU - Mohagheghi, Mohammad Ali

AU - Rozek, Laura

AU - Brennan, Paul

AU - Poustchi, Hossein

AU - Etemadi, Arash

AU - Pukkala, Eero

AU - Schüz, Joachim

AU - Malekzadeh, Reza

AU - Weiderpass, Elisabete

AU - Rahimi-Movaghar, Afarin

AU - Boffetta, Paolo

AU - Kamanagar, Farin

AU - Zendehdel, Kazem

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Scant evidence exists to support the association of opium use with head and neck cancer, limited to the larynx and oral cavity. In a multicenter case-control study—Iran Opium and Cancer study, we recruited 633 cases of head and neck squamous cell carcinoma (HNSCC) (254 lip and oral cavity, 54 pharynx, 327 larynx and 28 other subsites within the head and neck) and 3065 frequency-matched controls from April 2016 to April 2019. Odds ratios (ORs) for opium use and 95% confidence intervals (95% CIs) were obtained using mixed-effects logistic regression because of heterogeneity among centers. The adjusted OR (95% CI) for regular opium use was 3.76 (2.96-4.79) for all HNSCC combined. Strong dose-response effects were observed by frequency or amount of use, and duration of use. Regular opium uses significantly increased the risk of HNSCC of the pharynx, larynx and other subsites within the head and neck with OR (95% CI) of 2.90 (1.40-6.02), 6.55 (4.69-9.13) and 5.95 (2.41-14.71), respectively. The observed associations were significant even among never tobacco smokers (including cigarette and water-pipe smoking). Moreover, by the multiplicative interaction scale, the effect of opium use could be varied by cigarette smoking on HNSCC, 8.16 (6.20-10.74). For the first time, the current study showed opium users have an increased risk of several anatomic subsites of HNSCC.

AB - Scant evidence exists to support the association of opium use with head and neck cancer, limited to the larynx and oral cavity. In a multicenter case-control study—Iran Opium and Cancer study, we recruited 633 cases of head and neck squamous cell carcinoma (HNSCC) (254 lip and oral cavity, 54 pharynx, 327 larynx and 28 other subsites within the head and neck) and 3065 frequency-matched controls from April 2016 to April 2019. Odds ratios (ORs) for opium use and 95% confidence intervals (95% CIs) were obtained using mixed-effects logistic regression because of heterogeneity among centers. The adjusted OR (95% CI) for regular opium use was 3.76 (2.96-4.79) for all HNSCC combined. Strong dose-response effects were observed by frequency or amount of use, and duration of use. Regular opium uses significantly increased the risk of HNSCC of the pharynx, larynx and other subsites within the head and neck with OR (95% CI) of 2.90 (1.40-6.02), 6.55 (4.69-9.13) and 5.95 (2.41-14.71), respectively. The observed associations were significant even among never tobacco smokers (including cigarette and water-pipe smoking). Moreover, by the multiplicative interaction scale, the effect of opium use could be varied by cigarette smoking on HNSCC, 8.16 (6.20-10.74). For the first time, the current study showed opium users have an increased risk of several anatomic subsites of HNSCC.

KW - drug-related disorders

KW - morphine

KW - neoplasm

KW - opium

KW - otorhinolaryngologic neoplasms

UR - https://www.scopus.com/pages/publications/85092532395

U2 - 10.1002/ijc.33289

DO - 10.1002/ijc.33289

M3 - Article

C2 - 32895947

AN - SCOPUS:85092532395

SN - 0020-7136

VL - 148

SP - 1066

EP - 1076

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 5

ER -

Opium use and the risk of head and neck squamous cell carcinoma

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Keywords

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