Optimizing combinatorial library construction via split synthesis

Barry Cohen; Steven Skiena

doi:10.1145/299432.299467

Optimizing combinatorial library construction via split synthesis

Barry Cohen
, Steven Skiena

Computer Science

Stony Brook University

Research output: Contribution to conference › Paper › peer-review

5 Scopus citations

Abstract

A new algorithmically-intensive optimized split-synthesis technology is proposed for fabricating combinatorial chemistry libraries, and the potential of the method is evaluated through extensive simulation. The results indicate that the combinatorial approach can achieve significant improvements across a range of input sizes and on varied alphabets. Both methods may be effectively applied to DNA/RNA synthesis with an alphabet of four, and to protein synthesis with an alphabet of 20.

Original language	English
Pages	124-133
Number of pages	10
DOIs	https://doi.org/10.1145/299432.299467
State	Published - 1999
Event	Proceedings of the 1999 3rd Annual International Conference on Computational Molecular Biology, RECOMB '99 - Lyon Duration: Apr 11 1999 → Apr 14 1999

Conference

Conference	Proceedings of the 1999 3rd Annual International Conference on Computational Molecular Biology, RECOMB '99
City	Lyon
Period	04/11/99 → 04/14/99

Access to Document

10.1145/299432.299467

Cite this

@conference{86e77d9a75644980bc339bdb522dce8f,

title = "Optimizing combinatorial library construction via split synthesis",

abstract = "A new algorithmically-intensive optimized split-synthesis technology is proposed for fabricating combinatorial chemistry libraries, and the potential of the method is evaluated through extensive simulation. The results indicate that the combinatorial approach can achieve significant improvements across a range of input sizes and on varied alphabets. Both methods may be effectively applied to DNA/RNA synthesis with an alphabet of four, and to protein synthesis with an alphabet of 20.",

author = "Barry Cohen and Steven Skiena",

year = "1999",

doi = "10.1145/299432.299467",

language = "English",

pages = "124--133",

note = "Proceedings of the 1999 3rd Annual International Conference on Computational Molecular Biology, RECOMB '99 ; Conference date: 11-04-1999 Through 14-04-1999",

}

TY - CONF

T1 - Optimizing combinatorial library construction via split synthesis

AU - Cohen, Barry

AU - Skiena, Steven

PY - 1999

Y1 - 1999

N2 - A new algorithmically-intensive optimized split-synthesis technology is proposed for fabricating combinatorial chemistry libraries, and the potential of the method is evaluated through extensive simulation. The results indicate that the combinatorial approach can achieve significant improvements across a range of input sizes and on varied alphabets. Both methods may be effectively applied to DNA/RNA synthesis with an alphabet of four, and to protein synthesis with an alphabet of 20.

AB - A new algorithmically-intensive optimized split-synthesis technology is proposed for fabricating combinatorial chemistry libraries, and the potential of the method is evaluated through extensive simulation. The results indicate that the combinatorial approach can achieve significant improvements across a range of input sizes and on varied alphabets. Both methods may be effectively applied to DNA/RNA synthesis with an alphabet of four, and to protein synthesis with an alphabet of 20.

UR - https://www.scopus.com/pages/publications/0032642167

U2 - 10.1145/299432.299467

DO - 10.1145/299432.299467

M3 - Paper

AN - SCOPUS:0032642167

SP - 124

EP - 133

T2 - Proceedings of the 1999 3rd Annual International Conference on Computational Molecular Biology, RECOMB '99

Y2 - 11 April 1999 through 14 April 1999

ER -

Optimizing combinatorial library construction via split synthesis

Abstract

Conference

Access to Document

Other files and links

Fingerprint

Cite this