TY - GEN
T1 - Organofluorine chemistry at the biomedical interface
T2 - A case study on fluoro-taxoid anticancer agents
AU - Ojima, Iwao
AU - Kuznetsova, Larissa V.
AU - Sun, Liang
PY - 2007
Y1 - 2007
N2 - New and effective biochemical tools as well as medicinal and therapeutic agents have been successfully developed through strategic incorporation of fluorine(s) based on the rational design by taking into account the special properties of fluorine. Fluorinated analogues of biologically active molecules can also serve as excellent probes for the investigation of biochemical mechanisms. 19F-NMR can provide unique and powerful tools for the structural and mechanistic investigations in chemical biology. This article describes our recent studies on the use of fluorine in the medicinal chemistry and chemical biology of taxane anticancer agents, exploiting the unique nature of this element, as a showcase of the "current fluoroorganic chemistry" at the biomedical interface.
AB - New and effective biochemical tools as well as medicinal and therapeutic agents have been successfully developed through strategic incorporation of fluorine(s) based on the rational design by taking into account the special properties of fluorine. Fluorinated analogues of biologically active molecules can also serve as excellent probes for the investigation of biochemical mechanisms. 19F-NMR can provide unique and powerful tools for the structural and mechanistic investigations in chemical biology. This article describes our recent studies on the use of fluorine in the medicinal chemistry and chemical biology of taxane anticancer agents, exploiting the unique nature of this element, as a showcase of the "current fluoroorganic chemistry" at the biomedical interface.
UR - https://www.scopus.com/pages/publications/36749104372
U2 - 10.1021/bk-2007-0949.ch017
DO - 10.1021/bk-2007-0949.ch017
M3 - Conference contribution
AN - SCOPUS:36749104372
SN - 0841274037
SN - 9780841274037
T3 - ACS Symposium Series
SP - 288
EP - 304
BT - Current Fluoroorganic Chemistry New Synthetic Directions, Technologies, Materials, and Biological Applications
PB - American Chemical Society
ER -