TY - JOUR
T1 - Outcomes of intended temporary stomas in Crohn's disease (INTESTINE study)
T2 - International, multicentre, retrospective study
AU - INTESTINE Study Group
AU - Perrott, Claire
AU - Calini, Giacomo
AU - Gori, Alice
AU - Rottoli, Matteo
AU - Flacco, Maria E.
AU - Manzoli, Lamberto
AU - Garoufalia, Zoe
AU - Wexner, Steven D.
AU - Kontovounisios, Christos
AU - Elhadi, Muhammed
AU - Celentano, Valerio
AU - Avellaneda, N.
AU - Potolicchio, A.
AU - Muñoz, J. P.
AU - Avellaneda, N.
AU - Abdelrahman, A. S.
AU - Mostafa, Sara Mansour
AU - De' Angelis, N.
AU - Schena, C. A.
AU - Marchegiani, F.
AU - Kelm, M.
AU - Flemming, S.
AU - Lock, J.
AU - Politis, D.
AU - Ioannis, P.
AU - Mangana, O.
AU - Chardalias, L.
AU - Zager, Y.
AU - Horesh, N.
AU - Terrosu, G.
AU - Martinuzzo, L.
AU - Muschitiello, D.
AU - Biddau, C.
AU - Braini, A.
AU - Tumminelli, F.
AU - Cardelli, S.
AU - Belvedere, A.
AU - Isopi, C.
AU - Gallo, G.
AU - Trompetto, M.
AU - Clerico, G.
AU - Realis Luc, A.
AU - Gallo, G.
AU - Mingoli, A.
AU - Lapolla, P.
AU - Brachini, G.
AU - Mazzarella, G.
AU - Ghazouani, O.
AU - Galleano, R.
AU - Monzur, F.
N1 - Publisher Copyright:
© 2025 The Author(s).
PY - 2025/6/1
Y1 - 2025/6/1
N2 - Background Patients with ileocolic Crohn's disease often require surgery that can result in temporary stoma formation. Stomas are associated with a morbidity and can negatively impact quality of life. This study aimed to investigate the short-term (6-month) and mid-term (18-month) outcomes of intended temporary stomas in patients with Crohn's disease. Methods A trainee-led, international multicentre, retrospective study was conducted on all patients who underwent surgery for Crohn's disease in collaborating centres over 4 years (2017-2020). The primary outcome was the proportion of patients with Crohn's disease who underwent stoma reversal surgery by 6- and 18-month postoperative follow-up. Secondary outcomes included: the time interval between formation and reversal of stoma and predictors for non-reversal and stoma-related morbidity (postoperative complications, related readmissions and complications due to stoma reversal surgery). Results A total of 401 patients underwent stoma formation for Crohn's disease over the 4 years across the 44 collaborating centres. The temporary stomas had been reversed in 30.2% of patients at the 6-month and 56.9% at the 18-month follow-up. Reasons for non-reversal included ongoing medical treatment for Crohn's disease (respectively 6-month and 18-month: 37.6%, 39.3%), patient unfit for surgery (respectively 6-month and 18-month: 14.5%, 16.8%), patient preference (respectively 6-month and 18-month: 12.1%, 20.2%) and due to waiting lists (respectively 6-month and 18-month: 12.1%, 8.1%). Overall, 63.3% of patients had a temporary stoma reversed with a median time interval of 6 months. The stoma-related overall morbidity rate was 29.4%. Conclusions A large proportion of temporary stomas for Crohn's disease were not reversed at 6 and 18 months following initial surgery. Patients are exposed to the risk of non-reversal and risk of developing stoma complications for significantly longer intervals of time and, in some cases, indefinitely.
AB - Background Patients with ileocolic Crohn's disease often require surgery that can result in temporary stoma formation. Stomas are associated with a morbidity and can negatively impact quality of life. This study aimed to investigate the short-term (6-month) and mid-term (18-month) outcomes of intended temporary stomas in patients with Crohn's disease. Methods A trainee-led, international multicentre, retrospective study was conducted on all patients who underwent surgery for Crohn's disease in collaborating centres over 4 years (2017-2020). The primary outcome was the proportion of patients with Crohn's disease who underwent stoma reversal surgery by 6- and 18-month postoperative follow-up. Secondary outcomes included: the time interval between formation and reversal of stoma and predictors for non-reversal and stoma-related morbidity (postoperative complications, related readmissions and complications due to stoma reversal surgery). Results A total of 401 patients underwent stoma formation for Crohn's disease over the 4 years across the 44 collaborating centres. The temporary stomas had been reversed in 30.2% of patients at the 6-month and 56.9% at the 18-month follow-up. Reasons for non-reversal included ongoing medical treatment for Crohn's disease (respectively 6-month and 18-month: 37.6%, 39.3%), patient unfit for surgery (respectively 6-month and 18-month: 14.5%, 16.8%), patient preference (respectively 6-month and 18-month: 12.1%, 20.2%) and due to waiting lists (respectively 6-month and 18-month: 12.1%, 8.1%). Overall, 63.3% of patients had a temporary stoma reversed with a median time interval of 6 months. The stoma-related overall morbidity rate was 29.4%. Conclusions A large proportion of temporary stomas for Crohn's disease were not reversed at 6 and 18 months following initial surgery. Patients are exposed to the risk of non-reversal and risk of developing stoma complications for significantly longer intervals of time and, in some cases, indefinitely.
UR - https://www.scopus.com/pages/publications/105008259265
U2 - 10.1093/bjsopen/zraf010
DO - 10.1093/bjsopen/zraf010
M3 - Article
C2 - 40454941
AN - SCOPUS:105008259265
SN - 2474-9842
VL - 9
JO - BJS Open
JF - BJS Open
IS - 3
M1 - zraf010
ER -