Overview of acid and neutral sphingomyelinases in cell signaling

Youssef Zeidan; Norma Marchesini; Yusuf A. Hannun

doi:10.1007/4-431-34200-1_12

Overview of acid and neutral sphingomyelinases in cell signaling

Youssef Zeidan
, Norma Marchesini
, Yusuf A. Hannun

Cancer Center

Medical University of South Carolina

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase.

Original language	English
Title of host publication	Sphingolipid Biology
Publisher	Springer Japan
Pages	167-181
Number of pages	15
ISBN (Print)	4431341986, 9784431341987
DOIs	https://doi.org/10.1007/4-431-34200-1_12
State	Published - 2006

Keywords

apoptosis
ceramide
FAN (factor associated with N-SMase activation)
Niemann Pick disease (NPD)
sphingomyelinase

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10.1007/4-431-34200-1_12

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title = "Overview of acid and neutral sphingomyelinases in cell signaling",

abstract = "Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase.",

keywords = "apoptosis, ceramide, FAN (factor associated with N-SMase activation), Niemann Pick disease (NPD), sphingomyelinase",

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doi = "10.1007/4-431-34200-1\_12",

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AU - Zeidan, Youssef

AU - Marchesini, Norma

AU - Hannun, Yusuf A.

PY - 2006

Y1 - 2006

N2 - Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase.

AB - Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase.

KW - apoptosis

KW - ceramide

KW - FAN (factor associated with N-SMase activation)

KW - Niemann Pick disease (NPD)

KW - sphingomyelinase

UR - https://www.scopus.com/pages/publications/84900702442

U2 - 10.1007/4-431-34200-1_12

DO - 10.1007/4-431-34200-1_12

M3 - Chapter

AN - SCOPUS:84900702442

SN - 4431341986

SN - 9784431341987

SP - 167

EP - 181

BT - Sphingolipid Biology

PB - Springer Japan

ER -

Overview of acid and neutral sphingomyelinases in cell signaling

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Keywords

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