TY - JOUR
T1 - Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake
AU - Collatuzzo, Giulia
AU - Alicandro, Gianfranco
AU - Bertuccio, Paola
AU - Pelucchi, Claudio
AU - Bonzi, Rossella
AU - Palli, Domenico
AU - Ferraroni, Monica
AU - Ye, Weimin
AU - Plymoth, Amelie
AU - Zaridze, David
AU - Maximovich, Dmitry
AU - Aragones, Nuria
AU - Castaño-Vinyals, Gemma
AU - Vioque, Jesus
AU - Garcia De La Hera, Manoli
AU - Zhang, Zuo Feng
AU - Hu, Jinfu
AU - Lopez-Carrillo, Lizbeth
AU - López-Cervantes, Malaquías
AU - Dalmartello, Michela
AU - Mu, Lina
AU - Ward, Mary H.
AU - Rabkin, Charles
AU - Yu, Guo Pei
AU - Camargo, M. Constanza
AU - Curado, Maria Paula
AU - Lunet, Nuno
AU - Negri, Eva
AU - La Vecchia, Carlo
AU - Boffetta, Paolo
N1 - Publisher Copyright:
© 2022 Author(s) (or their employer(s)).
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Background: Peptic ulcer disease (PUD) and gastric cancer (GC) are more prevalent in individuals with low socioeconomic status (SES) and share several risk factors. The aim of this study was to investigate the mediating role of PUD in the association between established risk factors and GC. Methods: We conducted a pooled analysis of 12 studies from the Stomach Cancer Pooling Project Consortium, including a total of 4877 GC cases and 11 808 controls. We explored the mediating role of PUD in the association between SES, tobacco smoking, heavy alcohol drinking and salt intake, and GC. Also, we assessed the ORs and 95% CIs of the risk factors and both PUD and GC. Results: PUD mediated 36% of the smoking effect mainly among men. Other risk factors were only slightly mediated by PUD (SES, 5.3%; heavy alcohol drinking, 3.3%; and salt intake, 2.5%). No significant difference was found when excluding PUD diagnosed within 2 years from GC. Conclusions: Our study provides innovative information on the mechanism of stomach mucosal damage leading to PUD and GC, with respect to the effect of tobacco smoking in particular.
AB - Background: Peptic ulcer disease (PUD) and gastric cancer (GC) are more prevalent in individuals with low socioeconomic status (SES) and share several risk factors. The aim of this study was to investigate the mediating role of PUD in the association between established risk factors and GC. Methods: We conducted a pooled analysis of 12 studies from the Stomach Cancer Pooling Project Consortium, including a total of 4877 GC cases and 11 808 controls. We explored the mediating role of PUD in the association between SES, tobacco smoking, heavy alcohol drinking and salt intake, and GC. Also, we assessed the ORs and 95% CIs of the risk factors and both PUD and GC. Results: PUD mediated 36% of the smoking effect mainly among men. Other risk factors were only slightly mediated by PUD (SES, 5.3%; heavy alcohol drinking, 3.3%; and salt intake, 2.5%). No significant difference was found when excluding PUD diagnosed within 2 years from GC. Conclusions: Our study provides innovative information on the mechanism of stomach mucosal damage leading to PUD and GC, with respect to the effect of tobacco smoking in particular.
KW - Alcohol
KW - Gastric cancer
KW - Mediation analysis
KW - Peptic ulcer disease
KW - Salt
KW - Smoking
KW - Socioeconomic status
UR - https://www.scopus.com/pages/publications/85134843572
U2 - 10.1136/jech-2022-219074
DO - 10.1136/jech-2022-219074
M3 - Article
C2 - 35831132
AN - SCOPUS:85134843572
SN - 0143-005X
VL - 76
SP - 861
EP - 866
JO - Journal of Epidemiology and Community Health
JF - Journal of Epidemiology and Community Health
IS - 10
ER -