Peroxyacetyl nitrate: Measurement of its mutagenic activity using the Salmonella/mammalian microsome reversion assay

T. E. Kleindienst; P. B. Shepson; E. O. Edney; L. D. Claxton

doi:10.1016/0165-1218(85)90106-5

Peroxyacetyl nitrate: Measurement of its mutagenic activity using the Salmonella/mammalian microsome reversion assay

T. E. Kleindienst
, P. B. Shepson
, E. O. Edney
, L. D. Claxton

Office of the Dean SOMAS

Northrop Services Inc., North Carolina
United States Environmental Protection Agency

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35 Scopus citations

Abstract

Exposures of Salmonella typhimurium strain TA100 with and without S9 metabolic activation to low ppm levels of pure peroxyacetyl nitrate (PAN) in the gas phase were conducted. Measurements of the gas-phase PAN exposure concentration and the concentration of its decomposition products in surrogate test media led to a measured mutagenic activity of 34 ± 5 revertants/μmole. The data indicate that PAN is a relatively weak direct-acting mutagen with TA100.

Original language	English
Pages (from-to)	123-128
Number of pages	6
Journal	Mutation Research/Genetic Toxicology
Volume	157
Issue number	2-3
DOIs	https://doi.org/10.1016/0165-1218(85)90106-5
State	Published - 1985

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title = "Peroxyacetyl nitrate: Measurement of its mutagenic activity using the Salmonella/mammalian microsome reversion assay",

abstract = "Exposures of Salmonella typhimurium strain TA100 with and without S9 metabolic activation to low ppm levels of pure peroxyacetyl nitrate (PAN) in the gas phase were conducted. Measurements of the gas-phase PAN exposure concentration and the concentration of its decomposition products in surrogate test media led to a measured mutagenic activity of 34 ± 5 revertants/μmole. The data indicate that PAN is a relatively weak direct-acting mutagen with TA100.",

author = "Kleindienst, \{T. E.\} and Shepson, \{P. B.\} and Edney, \{E. O.\} and Claxton, \{L. D.\}",

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T1 - Peroxyacetyl nitrate

T2 - Measurement of its mutagenic activity using the Salmonella/mammalian microsome reversion assay

AU - Kleindienst, T. E.

AU - Shepson, P. B.

AU - Edney, E. O.

AU - Claxton, L. D.

PY - 1985

Y1 - 1985

N2 - Exposures of Salmonella typhimurium strain TA100 with and without S9 metabolic activation to low ppm levels of pure peroxyacetyl nitrate (PAN) in the gas phase were conducted. Measurements of the gas-phase PAN exposure concentration and the concentration of its decomposition products in surrogate test media led to a measured mutagenic activity of 34 ± 5 revertants/μmole. The data indicate that PAN is a relatively weak direct-acting mutagen with TA100.

AB - Exposures of Salmonella typhimurium strain TA100 with and without S9 metabolic activation to low ppm levels of pure peroxyacetyl nitrate (PAN) in the gas phase were conducted. Measurements of the gas-phase PAN exposure concentration and the concentration of its decomposition products in surrogate test media led to a measured mutagenic activity of 34 ± 5 revertants/μmole. The data indicate that PAN is a relatively weak direct-acting mutagen with TA100.

UR - https://www.scopus.com/pages/publications/0022263220

U2 - 10.1016/0165-1218(85)90106-5

DO - 10.1016/0165-1218(85)90106-5

M3 - Article

C2 - 3894956

AN - SCOPUS:0022263220

SN - 0165-1218

VL - 157

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JO - Mutation Research/Genetic Toxicology

JF - Mutation Research/Genetic Toxicology

IS - 2-3

ER -

Peroxyacetyl nitrate: Measurement of its mutagenic activity using the Salmonella/mammalian microsome reversion assay

Abstract

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