PETglove™: A new technology for portable molecular imaging

PET (Positron Emission Tomography) scanning has become a dominant force in oncology care because of its ability to identify regions of abnormal function. The current generation of PET scanners is focused on whole-body imaging, and does not address aspects that might be required by surgeons or other practitioners interested in the function of particular body parts. We are therefore developing and testing a new class of hand-operated molecular imaging scanners designed for use with physical examinations and intraoperative visualization. These devices integrate several technological advances, including (1) nanotechnology-based quantum photodetectors for high performance at low light levels, (2) continuous position tracking of the detectors so that they form a larger 'virtual detector', and (3) novel reconstruction algorithms that do not depend on a circular or ring geometry. The first incarnations of this device will be in the form of a glove with finger-mounted detectors or in a "sash" of detectors that can be draped over the patient. Potential applications include image-guided biopsy, surgical resection of tumors, assessment of inflammatory conditions, and early cancer detection. Our first prototype is in development now along with a clinical protocol for pilot testing.